2020
DOI: 10.1007/s12072-020-10074-6
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Abstract: Background and aims Coronavirus disease 2019 (COVID-19) pandemic is ongoing. Except for lung injury, it is possible that COVID-19 patients develop liver injury. Thus, we conducted a systematic review and meta-analysis to explore the incidence, risk factors, and prognosis of abnormal liver biochemical tests in COVID-19 patients. Methods PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP, and Wanfang databases were searched. The incidence of abnormal liver biochemical tests, in… Show more

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Cited by 105 publications
(113 citation statements)
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“…Elevated liver biochemical indicators are common in COVID-19, resulting in severe COVID-19 (49,50). Patients with rheumatic diseases are at high risk for COVID-19 infection due to their immune conditions (51).…”
Section: Discussionmentioning
confidence: 99%
“…Elevated liver biochemical indicators are common in COVID-19, resulting in severe COVID-19 (49,50). Patients with rheumatic diseases are at high risk for COVID-19 infection due to their immune conditions (51).…”
Section: Discussionmentioning
confidence: 99%
“…There is evidence that antihypertensive drugs prevent patients with comorbid hypertension from severe pneumonia Chronic respiratory conditions are also associated with the severity of COVID-19 (48). Elevated liver biochemical indicators are common in COVID-19 resulting in sever COVID-19 (49,50). Patients with rheumatic diseases are high risk for COVID-19 infection due to their immune conditions (51).…”
Section: Discussionmentioning
confidence: 99%
“…Han sido publicados diversos estudios que manifiestan la alteración de la función hepática en pacientes con infección por SARS-CoV-2 severa [14][15][16]. Este hallazgo sugiere que los hepatocitos y colangiocitos constituyen dianas potenciales de la infección por SARS-CoV-2 debido a que expresan el receptor ECA2, sobre el que actúa directamente el virus.…”
Section: Total N= Leves N= Graves N=unclassified
“…Este hallazgo sugiere que los hepatocitos y colangiocitos constituyen dianas potenciales de la infección por SARS-CoV-2 debido a que expresan el receptor ECA2, sobre el que actúa directamente el virus. Además, se ha demostrado una mayor susceptibilidad a esta infección en pacientes con disfunción hepática preexistente debido a un incremento en la expresión de ECA2, lo que obliga a una monitorización más exhaustiva de la función hepática [14,15]. El aumento de la concentración de indicadores bioquímicos, entre los que se encuentra la GGT, en el momento del ingreso hospitalario es mayor en pacientes graves, coincidiendo los resultados de este trabajo con diversos estudios publicados [15,16].…”
Section: Total N= Leves N= Graves N=unclassified
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