Incidence of Vestibular Schwannoma and Neurofibromatosis 2 in the North West of England over a 10-year Period: Higher Incidence than Previously Thought

Abstract

The incidence of VS is rising almost certainly due to increasing diagnosis in the magnetic resonance imaging era. At current rates, 1 per 1,000 individuals will be diagnosed with VS in their lifetime. More VS than previously thought are due to NF2, which may be because of recognition of mosaic forms of the disease.

Empirical development of improved diagnostic criteria for neurofibromatosis 2

“…[31][32][33][34] Most importantly, we have begun to understand the molecular pathogenesis of NF2, 1,[35][36][37] and this is permitting the development of novel therapeutic initiatives. 25,38 -41 Both NF2 and other conditions with which it may be confused clinically are being recognized more frequently, 42 probably because of the availability of high-quality MRI. Adoption of the Baser criteria as the clinical standard for diagnosis of NF2 is, therefore, both opportune and important for optimal patient care.…”

Mutation spectrum and differential gene expression in cystic and solid vestibular schwannoma

“…2,3 The tumor arises from the vestibular branch of the eighth cranial nerve. Asymmetric hearing loss, tinnitus, disequilibrium, facial numbness, and weakness are presenting symptoms.…”

Bilateral lower limb paralysis as initial symptom of neurofibromatosis type 2: A case report

“…NF2 is rare and has a reported incidence of 1:25,000 to 1:40,000. [1,2] Bilateral vestibular schwannomas (VSs) develop in more than 90% of patients with NF2, and approximately half of these patients complain of deafness. [3] Other neurologic lesions, including those involving other cranial nerves, the spinal cords and peripheral nerves, are common lesions in patients with NF2.…”