Incidence of Tinea capitis in São Paulo, Brazil

Moraes, Miriam S.; Godoy-Martínez, Patricio; Alchorne, M. M. A.; Boatto, Humberto Fabio; Fischman, Olga

doi:10.1007/s11046-006-0031-z

Cited by 17 publications

(23 citation statements)

References 26 publications

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“…But in a similar study in Brazil, Moraes et al. [6] also reported isolation of T. rubrum from scalp of children, which accounted for 0.9% of the aetiologic agents they encountered.…”

Section: Discussionmentioning

confidence: 94%

Tinea capitis among primary school children in Anambra state of Nigeria

Emele

Oyeka

2008

Mycoses

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Tinea capitis continues to be a common problem of infancy and childhood, particularly among those living in unhygienic crowded conditions. The prevalence and aetiology of tinea capitis have not been well defined in Anambra state of Nigeria - hence the need to undertake this study. A total of 47,723 primary school children residing in different regions of the State was screened for tinea capitis between 2002 and 2005. Of this number, 4498 (9.4%) had tinea capitis. The highest prevalence of the disease occurred in the Southern region of the state (12.6%). Schools in urban areas recorded lower prevalence of the disease. Male : female prevalence ratio of 1.6 : 1 was recorded. Tinea capitis occurred significantly more in children below 10 years of age than in those above this age (chi(2 )= 3.178; P < 0.10). Of 502 isolates recovered in culture, Microsporum audouinii was the most prevalent (42%), followed by M. ferrugineum (17%) and Trichophyton mentagrophytes (16%). Four of the samples revealed spore head of Aspergillus spp. in direct sample microscopy. A total of 29 (6%) isolates was atypical forms. The majority (91%) of children with the lesion came from families of three or more children, living in crowded apartments. Results showed that tinea capitis remains an important public health problem in Anambra state of Nigeria.

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“…But in a similar study in Brazil, Moraes et al. [6] also reported isolation of T. rubrum from scalp of children, which accounted for 0.9% of the aetiologic agents they encountered.…”

Section: Discussionmentioning

confidence: 94%

Tinea capitis among primary school children in Anambra state of Nigeria

Emele

Oyeka

2008

Mycoses

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“…The most common isolates were M. canis (70.5%) and T. tonsurans (23.2%), followed by T. mentagrophytes (3.6%), Microsporum gypseum (1.8%) and T. rubrum (0.9%). 10 Among the fungi isolated from skin infections, the anthopophilic dermatophyte T. rubrum is the most frequent in clinical cases of tinea pedis (feet), tinea unguium (nails), tinea corporis (body) and tinea cruris (groin region). 4 Epidemiological studies conducted with university students from Sao Paulo demonstrated the occurrence of dermatophytes in 18.2% of the studied population; T. rubrum was isolated in 80% of the cases and T. mentagrophytes, in 20%.…”

Section: Epidemiological Aspectsmentioning

confidence: 99%

Dermatófitos: interação patógeno-hospedeiro e resistência a antifúngicos

Peres¹,

Maranhão²,

Rossi

et al. 2010

An. Bras. Dermatol.

156

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Cutaneous mycoses are among the most common infections in humans and have become an important public health issue because they cause invasive infections in immunocompromised patients. During the infectious process, dermatophyte-host interactions trigger specific metabolic adaptations that allow the pathogen to adhere to and penetrate the host tissue, scavenge nutrients, and overcome the host defense mechanisms. This metabolic shift and the interplay between metabolism, morphogenesis and stress response are important factors that have been extensively studied in several pathogens. Host cells also respond to the pathogen stimuli by activating intracellular signaling pathways that trigger the immune response against the infectious agent. The comprehension of the molecular aspects of these responses may help to establish new therapeutical strategies. In this review, different aspects of the biology of dermatophytes are addressed, with emphasis on the dermatophyte-host interaction and the mechanisms of antifungal resistance. Keywords: Antifungal agents; Dermatomycoses; Drug resistance, fungal; Host-pathogen interactions Resumo: As micoses cutâneas estão entre as infecções mais comuns em humanos e se tornaram um importante problema de saúde pública, principalmente por causarem infecções invasivas em pacientes imunodeprimidos. Durante a infecção, a interação dermatófito-hospedeiro desencadeia adaptações metabólicas específicas que permitem aos patógenos aderirem e penetrarem no tecido, remodelando seu metabolismo para captar nutrientes e superar os mecanismos de defesa do hospedeiro. Esse remodelamento metabólico e a inter-relação entre metabolismo, morfogênese e resposta ao estresse são importantes fatores que estão sendo intensamente avaliados em diversos patógenos. As células do hospedeiro também respondem aos estímulos do patógeno, ativando vias de sinalização intracelular que culminam no desencadeamento de uma resposta imune contra o agente infeccioso. O entendimento molecular dessas respostas metabólicas pode ajudar no estabelecimento de novas estratégias terapêuti-cas. Nesta revisão, são abordados diferentes aspectos da biologia dos dermatófitos, com ênfase na interação dermatófito-hospedeiro e nos mecanismos de resistência a antifúngicos.

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“…Studies performed in Brazil (8, 14, 16), Greece (9) and China (23) show that M. canis is the most prevalently isolated agent on the scalp and hair. However, in our study this agent was the second most commonly isolated, perhaps for not adapting well to the climactic conditions or because of the age group of the study population.…”

mentioning

confidence: 99%