1977
DOI: 10.1001/archderm.113.4.436
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Incidence of skin carcinoma after renal transplantation

Abstract: The development of de novo malignant neoplasms after renal transplantation continues to be of importance. The incidence of skin cancer in the renal transplant population at the University of Minnesota Hospital is compared with that expected on the basis of rates from the special nonmelanoma part of the Third National Cancer Survey. Overall, the risk of skin cancer in the renal transplant population was 7.1 times that expected. This excess was due primarily to squamous cell carcinomas, which were 36.4 times as … Show more

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Cited by 36 publications
(8 citation statements)
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“…Squamous cell carcinoma is the predominant type of skin cancer, but an increased incidence of Kaposi's sarcoma, basal cell carcinoma and malignant melanoma was also observed. Kaposi's sarcoma developed in 3 of our patients, an incidence of 2.6%, higher than reported by Hoxtell et al [14] and Zimmerman and Esch [6] (1.4% and 1%, respectively). In our group the difference could be due to racial factors, environmental factors, and possibly to the more potent immunosup-pressive regimens.…”
Section: Discussioncontrasting
confidence: 54%
“…Squamous cell carcinoma is the predominant type of skin cancer, but an increased incidence of Kaposi's sarcoma, basal cell carcinoma and malignant melanoma was also observed. Kaposi's sarcoma developed in 3 of our patients, an incidence of 2.6%, higher than reported by Hoxtell et al [14] and Zimmerman and Esch [6] (1.4% and 1%, respectively). In our group the difference could be due to racial factors, environmental factors, and possibly to the more potent immunosup-pressive regimens.…”
Section: Discussioncontrasting
confidence: 54%
“…Organ transplant recipients and patients chronically treated with immunosuppressive drugs show an increased susceptibility to viral infections and/or skin malignancy (1)(2)(3)(4). In patients receiving azathioprine and prednisolone therapy, skin-mediated immune functions are reduced (5).…”
Section: Introductionmentioning
confidence: 99%
“…Immunosuppressive medications used to treat organ transplant recipients greatly increase the likelihood of UV-induced skin cancers, and, in addition, these cancers are more aggressive than those observed in the general population (Hoxtell et al , 1977; Hartevelt et al , 1990). In spite of the immunogenicity of UV-induced skin tumors, they evade the host immune defenses that have evolved to eliminate neoplastic cells before they become invasive malignancies (Kripke, 1974).…”
Section: Immunology Of Photocarcinogenesismentioning
confidence: 99%