2000
DOI: 10.1507/endocrj.47.supplmarch_s57
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Abstract: Neoplasms may be one of the systemic complications to which we attribute high mortality in acromegaly. The present study was designed to investigate the incidence of malignant tumors in patients with acromegaly in the Japanese population. In this report, 44 patients (25 men and 19 women) with biochemically proven acromegaly were studied retrospectively and had a total 670 patient years of the duration of acromegaly. We investigated the incidence of malignant tumors. There were 5 patients with malignant tumors … Show more

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Cited by 34 publications
(23 citation statements)
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“…The authors also stated that there was no increase in mortality rate from malignant disease in general, but the colon cancer mortality rate was higher than expected. [12,15,21] found an increased cancer incidence compared to population tumor incidence rates in their smaller series. Recently, Barıs et al [22] confirmed an increased risk for all cancers in 1,634 acromegalic patients from Sweden and Denmark especially colon and rectum cancers.…”
Section: Discussionmentioning
confidence: 88%
“…The authors also stated that there was no increase in mortality rate from malignant disease in general, but the colon cancer mortality rate was higher than expected. [12,15,21] found an increased cancer incidence compared to population tumor incidence rates in their smaller series. Recently, Barıs et al [22] confirmed an increased risk for all cancers in 1,634 acromegalic patients from Sweden and Denmark especially colon and rectum cancers.…”
Section: Discussionmentioning
confidence: 88%
“…Standardized incidence ratio (SIR) was available from 11 series, and in three of them, cancer incidence was not increased (12,18,28). In five series, the estimated overall SIR for malignancies was increased by a magnitude of 1.5-to 3.4-fold (15,16,19,21,23), whereas in two studies, increased risk was only observed for women (13) and in one only for men (20) (Table 1). …”
Section: Incidence/prevalencementioning
confidence: 99%
“…A review of 17 series published between 1957 and 2015, where overall cancer incidence in acromegaly was investigated, revealed 7723 patients with 708 cases of cancer, resulting in a mean cancer incidence of 10.8%, with percentages varying from 4.8 to 21.3% (12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28). Standardized incidence ratio (SIR) was available from 11 series, and in three of them, cancer incidence was not increased (12,18,28).…”
Section: Incidence/prevalencementioning
confidence: 99%
“…Diseases of enhanced growth, such as acromegaly, are associated with increased risk of cancer (39)(40)(41). Research has demonstrated that high circulating levels of growth factors, such as insulin-like growth factors, are associated with increase for a variety of common cancers, such as those of the breast (42), prostate (43), lung (44), and colon (45).…”
Section: Genomic Imprinting and Growth Factorsmentioning
confidence: 99%