Incidence of intraspinal abnormalities in congenital scoliosis: a systematic review and meta-analysis

Wang, Xudong; Yu, Yangke; Yang, Ningning; Xia, Lei

doi:10.1186/s13018-020-02015-8

Cited by 11 publications

(10 citation statements)

References 29 publications

(49 reference statements)

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“…[ 35 ] These vertebral abnormalities can be diagnosed by antenatal ultrasound from the 12 th week of gestation or by magnetic resonance imaging. [ 36 ] According to several authors,[ 33 37 38 ] these congenital scoliosis are associated in 15%–43% of cases with intraspinal abnormalities that we have not looked for.…”

Section: Discussionmentioning

confidence: 93%

“…[ 32 ] Their prevalence is 1 per 1000–2000 live births, and the risk of occurrence is linked to environmental or genetic factors according to several authors. [ 32 33 34 ] According to Mackel et al ., more than half of these congenital forms are diagnosed after the age of 3 years and a quarter in the 1 st year of life, which agrees with our data. [ 32 ] They are dominated by the hemi-vertebrae such as in the series of Zhang et al .…”

Section: Discussionmentioning

confidence: 99%

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Epidemiological and Diagnostic Characteristics of Scoliosis in Children in a Single Tertiary Centre in Abidjan

Yaokreh¹,

Kouamé²,

Ali³

et al. 2022

African Journal of Paediatric Surgery

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Introduction: Scoliosis is the most frequent spine deformity in children. Epidemiological data are available in Western countries due to the systematic screening policies implemented at school. Unfortunately, in our country, there are neither national data nor screening policy for scoliosis. Are the epidemiological and diagnostic characteristics of scoliosis in our practice similar to the data in the literature? Patients and Methods: We retrospectively reviewed 106 medical records of patients under 19 years old between 2010 and 2019 at the 'Vivre Debout' Centre for structural scoliosis confirmed by spine X-ray with a Cobb angle ≥10°. The epidemiological and diagnostic characteristics were noted. The data were treated with Excel 2010. Results: The mean frequency of scoliosis was 10 cases/year. The male-to-female sex ratio was 1:1.3. The mean age at diagnosis was 11.2 ± 2.13 years. There was a family history of scoliosis in two cases (1.8%). Twenty-four girls (39.3%) out of 61 had had menarche at the time of diagnosis. The mean time from noticing deformity to consultation was 17.9 ± 21.9 months. Lateral deviation of the spine ( n = 77; 72.6%), hump ( n = 12; 11.3%) and pain ( n = 3; 2.8%) were the main complaints for consultation. In 14 cases (13.2%), the discovery was fortuitous during a medical examination for another complaint. The curvature was single in 88 cases (83%) and double in 18 (17%). The convexity was right in 69 cases (65.1%) and left in 37 (34.9%). Curvatures were thoracic ( n = 57; 53.8%), lumbar ( n = 10; 9.4%) and thoracolumbar ( n = 39; 36.8%). The average Cobb angle was 35.2° ±10.71° (range: 11°–90°). Curvatures were moderate (20°–40°) in 49 cases (46.2) and severe (>40°) in 18 (17%). The aetiologies were predominated by idiopathic causes ( n = 79; 74.5%), followed by congenital ( n = 16; 15.1%) and neuromuscular ( n = 11; 10.4%) causes. Conclusion: Scoliosis is uncommon in our practice. It is characterised by single curvature. The predominance of moderate and severe curvatures was due to delayed consultation.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Epidemiological and Diagnostic Characteristics of Scoliosis in Children in a Single Tertiary Centre in Abidjan

Yaokreh¹,

Kouamé²,

Ali³

et al. 2022

African Journal of Paediatric Surgery

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“…Among congenital spinal malformations are kyphosis and scoliosis, for example. According to Wang et al (44), congenital scoliosis is a curvature of the spine resulting from abnormal vertebral development, with an incidence in the general population of approximately 1/1,000 to 1/2,000, also resulting from environmental and genetic factors. Among the environmental factors, one can also consider the consumption of drugs and teas, for example.…”

Section: Discussionmentioning

confidence: 99%

The ethanolic extract of Salvia lachnostachys Benth is not maternotoxic, does not alter reproductive performance, but has teratogenic potential

Ortiza

Neves

Kassuya

et al. 2022

Preprint

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Salvia lachnostachys Benth is native to Brazil and has anti-inflammatory, anti-arthritic, cytotoxic, antitumor, and antihyperalgesic activities. The present study aimed to evaluate the effects of S. lachnostachys (EESl) ethanolic extract on reproductive performance, embryofetal development, and DNA integrity of pregnant female mice. Pregnant females were randomly divided into three experimental groups (n = 10): The Control group was treated with a vehicle, and treatment groups were administered with EESl at 100 and 1000 mg/kg, respectively. Treatment occurred by gavage throughout the gestational period until day 18. Afterward, reproductive performance, embryofetal development, and DNA integrity parameters were evaluated. The results indicated that EESl did not alter any reproductive performance parameters. However, it changed embryofetal outcome through reduced placental weight (EESl 100 mg/kg), decreased fetal weight (EESl 100 and 1000 mg/kg), and increased frequency of small for gestational age fetuses (EESl 1000 mg/kg). In addition, EES1 increased the frequency of external, visceral, and skeletal malformations. Because of the above, it is considered that EESl is not maternotoxic, does not alter reproductive performance, but does alter embryofetal development. Its use in the gestational period is not indicated due to its teratogenic potential.

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“…Врожденные деформации позвоночника (ВДП) у детей относят к наиболее тяжелой и инвалидизирующей патологии осевого скелета. Распространенность ВДП составляет около 0,5-1,0 на 1000 новорожденных [1][2]. Аномалии позвонков возникают из-за сбоев в процессах формирования или сегментации, которые происходят в первые 6 нед.…”

Section: обоснованиеunclassified

The influence of the <i>TBX6</i> gene on the development of congenital spinal deformities in children

Khalchitsky

Vissarionov

Kokushin

et al. 2021

Pediatr Traum Orthop Reconstr Surg

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BACKGROUND: Congenital deformities of the spine are a group of serious congenital defects of the vertebrae, which can manifest themselves in the clinical picture as an isolated pathology of the axial musculoskeletal system, and are associated with congenital defects of internal organs and other systems. Recently, the TBX6 gene has been identified as the genetic cause of congenital scoliosis in about 11% of cases. This subtype of scoliosis is classified as TBX6-associated congenital scoliosis. The TBX6-associated congenital scoliosis phenotype is characterized by butterfly-shaped vertebrae and hemivertebrae in the lower thoracic and lumbar regions without pronounced malformations of the spinal cord. AIM: Our aim is to study and evaluate data from foreign and domestic scientific publications devoted to the study of the candidate gene for congenital scoliosis TBX6. MATERIALS AND METHODS: The following databases of scientific publications such as PubMed, Cochrane Library, Web of Science, SCOPUS, MEDLINE, e-Library, Cyberleninka were used to write this review. The inclusion criteria were systematic reviews, meta-analyses, multicenter studies, controlled cohort studies, uncontrolled cohort studies of patients with congenital spinal deformities. The exclusion criteria were clinical cases, observations, conference proceedings, congenital scoliosis in genetic syndromes, congenital scoliosis associated with defects of the nervous system. RESULTS: In order to achieve this goal, 70 scientific publications were studied relating to the data analysis of the candidate gene for congenital scoliosis TBX6. Among 49 publications that were identified, 2 were domestics, and the rest were foreign publications. These studies provided information on the molecular analysis of genes that cause congenital spinal deformities in humans and animals. CONCLUSIONS: An analysis of the published research work on this topic indicates the presence of a significant effect of mutations in the TBX6 gene, leading to the appearance of congenital scoliosis. Advances in elucidating the genetic contribution to the development of congenital spinal deformities and the molecular etiology of clinical phenotypes may uncover the opportunities for further refinement of the classification of signs of congenital scoliosis in accordance with the underlying genetic etiology.

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Incidence of intraspinal abnormalities in congenital scoliosis: a systematic review and meta-analysis

Cited by 11 publications

References 29 publications

Epidemiological and Diagnostic Characteristics of Scoliosis in Children in a Single Tertiary Centre in Abidjan

Epidemiological and Diagnostic Characteristics of Scoliosis in Children in a Single Tertiary Centre in Abidjan

The ethanolic extract of Salvia lachnostachys Benth is not maternotoxic, does not alter reproductive performance, but has teratogenic potential

The influence of the <i>TBX6</i> gene on the development of congenital spinal deformities in children

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