Cardiac surgeries are considered as a big problem around the world; because of the consequences of surgical site infections. There are several risk factors which may lead to surgical infections. However, the factors are categorized into three groups of preoperative, perioperative and postoperative risk factors that may lead to microbial surgical site infections in patients with post cardiac surgery. The medical (morbidity and mortality) and financial consequences in association with surgical site infections are very significant and considerable. But, the use of standard sterilization protocols and accurate surgical methodologies may help to reduce the microbial infections in patients with cardiac surgery. For this reason, the focused aim of the present literature is to have a deep review in epidemiology, microbiology, pathogenesis and virulence and the risk factors pertaining to microbial surgical site infections in patients with post cardiac surgery.