Incidence of De Novo Nonmelanoma Skin Tumors After Liver Transplantation for Alcoholic and Nonalcoholic Liver Diseases

Jiménez-Romero, Carlos; Municio, Alejandro Manrique; Medina, Enrique; Colina, Francisco; Domene, P. Ortega; Sanz, R Gómez; Díaz, Juan Carlos Meneu; Usera, M. Abradelo de; Elola, A. Moreno; González, Esther

doi:10.1016/j.transproceed.2006.08.065

Cited by 26 publications

(9 citation statements)

References 14 publications

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“…Smoking has been recognized by several authors as a general [25], [26], [27] and specific risk factor for esophageal [12], skin [28] and lung [29] cancers. Unfortunately, one limitation of this study is that we were not able to evaluate smoking as a risk factor for DNT.…”

Section: Discussionmentioning

confidence: 99%

Early and Late De Novo Tumors after Liver Transplantation in Adults: The Late Onset of Bladder Tumors in Men

et al. 2013

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BackgroundDe novo tumors (DNT) after liver transplantation (LT) represent a growing concern.Patients and MethodsWe analyzed the incidence of DNT, type, time of onset, risk factors and mortality (as of 2010) in 494 adult patients transplanted in the last 26 years (1983–2009).ResultsDNT occurred in 41 (8.3%) of the patients. The Standardized Incidence Ratio (SIR) compared with the Italian population was 1.8. There was a higher incidence in males (SIR 2.0), an expected extremely high rate of Kaposi’s sarcoma (SIR 127.95) and unexpected higher rates of tumors of the bladder in males (SIR 3.3). The incidence of DNT was higher within the first two years of LT (SIR 2.7) for Kaposi’s sarcoma (SIR 393.3) and after 10 years (SIR 1.7) for bladder tumors (SIR 10.6). Multivariate analysis identified alcoholic cirrhosis (HR = 3.0, 95% CI = 1.2–7.8) and sclerosing cholangitis (HR = 3.5, 95% CI = 1.1–11.3) in the recipient as main risk factors for the occurrence of DNT.ConclusionsSurveillance protocols for DNT must be specifically oriented to patients transplanted for alcoholic cirrhosis and sclerosing cholangitis. They should focus on early detection of Kaposi’s sarcomas, and more remarkably, on late development bladder tumors in men after LT.

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Section: Discussionmentioning

confidence: 99%

Early and Late De Novo Tumors after Liver Transplantation in Adults: The Late Onset of Bladder Tumors in Men

et al. 2013

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“…A retrospective analysis of a cohort of liver transplant recipients reported that 25% of patients developed skin malignancy. 3,4 Interestingly, liver transplant recipients may have a higher rate of BCC compared to other organ transplants. 5 Nonmelanoma skin cancer appears on sunexposed skin in areas of field cancerization (ie, extensive areas of actinic damage with multiple keratotic lesions including actinic keratoses, Bowen disease, and keratoacanthoma).…”

Section: Learning Objectivesmentioning

confidence: 99%

Skin cancer in solid organ transplant recipients: Advances in therapy and management

Zwald

Brown

2011

Journal of the American Academy of Dermatology

269

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“…Overall, skin cancers are the most common de novo malignancies following organ transplantation (39, 40). The overall incidence of skin cancer following OLT has been reported to be 0.9–3.2% in large case series (23, 36) (Table 1) compared with 0.02% in the general population (27).…”

Section: Incidences Of Major De Novo Malignancies Following Orthotopimentioning

confidence: 99%

Risk factors and incidence of de novo malignancy in liver transplant recipients: a systematic review

Chak

Saab

2010

Liver International

108

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Orthotopic liver transplant (OLT) is an established life saving procedure for both acute and chronic liver failure, but incidences and risk factors for development of these malignancies are yet to be established. To determine the incidences and risk factors associated with de novo malignancy after OLT. We performed a systematic review of relevant epidemiological studies available on MEDLINE, which provided information on the incidences and risk factors for the development malignancies in adult OLT recipients published from 1983 to 2009. All data was compiled from retrospective studies. Independent risk factors for the development of de novo malignancy in adult OLT recipients were identified to be statistically significant including immunosuppression, hepatitis C virus infection, smoking, alcoholic cirrhosis and sun exposure. OLT recipients with smoking and alcohol history are of particular risk for head and neck and lung cancers. Primary sclerosing cholangitis and inflammatory bowel disease were found to be independent risk factors for colon cancer. Adult OLT recipients are at increased risk for the development of posttransplant malignancies and obviates the need for surveillance protocols that are safe and cost-effective. OLT recipients should be advised on taking proper precautions in the sun, smoking cessation, and eliminating alcohol consumption. Given the emergence of alcoholic cirrhosis as a leading indication for liver transplantation, the early detection of lung and head and neck cancers is of particular importance.

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Incidence of De Novo Nonmelanoma Skin Tumors After Liver Transplantation for Alcoholic and Nonalcoholic Liver Diseases

Cited by 26 publications

References 14 publications

Early and Late De Novo Tumors after Liver Transplantation in Adults: The Late Onset of Bladder Tumors in Men

Early and Late De Novo Tumors after Liver Transplantation in Adults: The Late Onset of Bladder Tumors in Men

Skin cancer in solid organ transplant recipients: Advances in therapy and management

Risk factors and incidence of de novo malignancy in liver transplant recipients: a systematic review

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