2017
DOI: 10.1001/jamadermatol.2016.4920
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Abstract: IMPORTANCESkin cancer is the most common malignancy occurring after organ transplantation. Although previous research has reported an increased risk of skin cancer in solid organ transplant recipients (OTRs), no study has estimated the posttransplant population-based incidence in the United States. OBJECTIVE To determine the incidence and evaluate the risk factors for posttransplant skin cancer, including squamous cell carcinoma (SCC), melanoma (MM), and Merkel cell carcinoma (MCC) in a cohort of US OTRs recei… Show more

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Cited by 223 publications
(188 citation statements)
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References 53 publications
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“…However, a molecular UV signature (DNA mutations that are typically caused by UV damage, such as C to T transitions that occur in the context of di-pyrimidines: C[C>T]N and N[C>T]C) has been demonstrated only in a subset of cases of MCPyV − MCCs 19,20 ; thus, the association with UV exposure in MCPyV + MCC might be related to other factors, such as UV-induced immune suppression. In fact, immune deficiencies have a crucial aetiological role: MCC is more-frequent in patients with leukaemia, lymphoma (particularly B cell chronic lymphocytic leukaemia 21,22 ) or HIV infection 23,24 and in those who are immunosuppressed as a result of organ transplantation or other causes 2527 . Notably, the age of onset of MCC is lower and the mortality is higher in immunosuppressed individuals than in immune-competent patients 28 ; these findings emphasize the crucial role of efficient immune surveillance in the control of tumour growth and progression.…”
Section: Epidemiologymentioning
confidence: 99%
“…However, a molecular UV signature (DNA mutations that are typically caused by UV damage, such as C to T transitions that occur in the context of di-pyrimidines: C[C>T]N and N[C>T]C) has been demonstrated only in a subset of cases of MCPyV − MCCs 19,20 ; thus, the association with UV exposure in MCPyV + MCC might be related to other factors, such as UV-induced immune suppression. In fact, immune deficiencies have a crucial aetiological role: MCC is more-frequent in patients with leukaemia, lymphoma (particularly B cell chronic lymphocytic leukaemia 21,22 ) or HIV infection 23,24 and in those who are immunosuppressed as a result of organ transplantation or other causes 2527 . Notably, the age of onset of MCC is lower and the mortality is higher in immunosuppressed individuals than in immune-competent patients 28 ; these findings emphasize the crucial role of efficient immune surveillance in the control of tumour growth and progression.…”
Section: Epidemiologymentioning
confidence: 99%
“…1,2 As a result of this success, malignancy is a common transplant complication, with non-melanoma skin cancers (NMSC) accounting for 95% of posttransplant malignancies. 5 A number of studies have evaluated clinical predictors of NMSC posttransplant [6][7][8] and robust predictors include age, sex, and type of immunosuppressive treatment. 5 A number of studies have evaluated clinical predictors of NMSC posttransplant [6][7][8] and robust predictors include age, sex, and type of immunosuppressive treatment.…”
Section: Introductionmentioning
confidence: 99%
“…3 Renal transplant recipients have an estimated prevalence of NMSC ranging from 2% to 18% 4 and an approximate 16-fold excess risk of developing basal cell carcinoma (BCC), and 65-fold increased risk of developing squamous cell carcinoma (SCC) relative to age-matched nontransplanted individuals. 5 A number of studies have evaluated clinical predictors of NMSC posttransplant [6][7][8] and robust predictors include age, sex, and type of immunosuppressive treatment. 6,8,9 The immunosuppressive regime chosen for a patient can have a dramatic effect on their risk of developing skin cancer, as immunosuppressants can impair the immune system's ability to scan for potentially oncogenic cells.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…78 Organ transplant recipients experience an increased risk of developing skin cancer, particularly cutaneous squamous cell carcinoma (SCC) compared to the general population. 81 Administration of voriconazole, a broad spectrum triazole antifungal mostly used in antifungal prophylaxis regimens, especially after LT, increases the risk of developing SCC in LT recipients. 82 The duration of exposure and cumulative high-dose exposure to this drug are both factors associated independently with SCC.…”
Section: An Cermentioning
confidence: 99%