Incidence and univariate models for lymphatic drainage disorders following management for cervical cancer

Abstract

AimTo clarify the incidence of lymphatic drainage disorders (LLD) after treatment for cervical cancer (CC) and to establish univariate models for their occurrence.MethodsA total of 263 eligible patients with CC were identified between 2010 and 2019. We conducted a case–control study and divided the study population into two subsamples of 12 and 251 CC survivors based on the presence/absence of LLD, respectively. The cumulative incidence was evaluated using the Kaplan–Meier method. Univariate models based on Pearson correlation coefficient were used to evaluate associations between explanatory variables and LLD.ResultsThe cumulative incidence of LLD began at 3.3% after the 7‐month follow‐up, reaching a plateau of 21.2% between 130 and 250 months of follow‐up.We detected correlation between LLD and number of removed para‐aortic lymph nodes (r = −0.39), number of pelvic lymphadenopathies (r = 0.16), pelvic lymphadenectomy (PL) (r = 0.16), age at diagnosis of CC (r = −0.1) and primary surgery (r = 0.1).ConclusionWe observed a cumulative incidence of LLD of 21.2%, which is in accord with other retrospective studies. Number of removed para‐aortic lymph nodes, number of pelvic lymphadenopathies, PL, age at diagnosis of CC and primary surgery were the most influential clinical factors associated with the occurrence of LLD in CC survivors.

Validation of the 2018 FIGO Staging System for Predicting the Prognosis of Patients With Stage IIIC Cervical Cancer

“…23 In contrast, patients with cervical cancer with PLNMs show diverse risk profiles, which is mainly attributable to additional variables such as bilateral presentation and the number of lymph nodes affected in such cases. 24,25 Comparison of the prognostic accuracies of lymph node staging systems (2018 FIGO, metastatic lymph node ratio, number, and the log-odds of lymph nodes metastasis) shows that the number of metastatic lymph nodes system most accurately predicts prognosis in patients with lymph node metastasis after radical operations. 26 This study highlights that the number of positive pelvic lymph nodes is an accurate predictor of prognosis in patients with stage IIIC1p (T1/T2a) cervical cancer.…”

Characteristics of systematic lymph node dissection and influencing factors of sentinel lymph node biopsy using carbon nanoparticles in endometrial carcinoma: a single-center study

“…Because of this, the lymphatic metastasis of EC is quite different from that of cervical cancer. Cervical cancer passes from the primary lesion to obturator lymph nodes and internal iliac lymph nodes, then goes upward into the common iliac lymph nodes, and finally goes into the para-arterial lymph nodes [ 33 ]. However, due to the existence of the three main lymphatic drainage pathways, endometrial tumors can directly skip the lower lymph nodes and enter the upper lymph nodes, so jumping metastasis is possible for EC.…”

Validation of The 2018 FIGO Staging System for Predicting The Prognosis of Patients With Stage IIIC Cervical Cancer

“…In contrast, patients with cervical cancer with PLNMs exhibit different risk pro les, mainly because of additional variables such as bilateral presentation and the number of lymph nodes [21][22]. A comparison of the prognostic accuracies of lymph node staging systems (2018 FIGO, metastatic lymph node ratio, number, and the log-odds of lymph nodes metastasis) shows that the number of lymph node metastasis system is the most accurate for predicting the prognosis of patients with lymph node metastasis after radical operation [23].…”