Incidence and Trends of Malignant and Benign Pancreatic Lesions in Yazd, Iran between 2001 and 2011

Abstract

In cases for which paraffin-embedded blocks were available, the specimens were evaluated by two independent pathologists blinded to the primary diagnosis. We extrapolated the frequency of malignant lesions in our study to the population of Yazd province, derived from national census data, to generate cancer incidence rates. Results: Final diagnosis of malignancy was made in 117 cases (66.1%), and the remainder (60 lesions, 33.9%) were classified as benign. Adenecarcinoma and neuroendocrine tumors were the two most common histological types of malignancy identified in 88 (75.2%) and 11 (9.4%) specimens, respectively. Crude annual incidence of pancreatic cancer was 0.55 per 100,000 person in 2001 and increased to 1.68 in 2011. Age standardized incidence rates in 2001 and 2011 were 0.75 and 2.68, respectively. A significant increasing trend in cancer incidence was observed during the 11 years of the study period (r=+0.856, p=0.009). Sex-stratified analysis, confirmed the observed trend in men (r=+0.728, p=0.034), but not women (r=+0.635, p=0.083). Conclusions: Over the past decade, incidence of pancreas malignancies has risen steadily in Yazd, Iran. Nevertheless, these figures are still substantially lower than those prevalent in developed nations.

Overview of Cancer Registration Research in the Asian Pacific from 2008-2013

“…I The five leading primary sites in males were liver, stomach, lung, esophagus, and colon/rectum; whereas in females Asian Pacific Journal of Cancer Prevention, Vol 14, 2013 4463 DOI:http://dx.doi.org/10.7314/APJCP.2013.14.8.4461 Overview of Cancer Registration Research in the Asian Pacific from 2008 they were liver, cervix, stomach, esophagus and breast . In Isfahan, lung, stomach, breast and prostate all increased over the period 2001(Moradpour and Fatemi, 2013. This confirmed earlier findings for increase with most frequent cancers being gastrointestinal in men and breast in women (Mokarian et al, 2011).…”

“…Siberia: Lung cancer, breast cancer, colorectal cancer, non-melanoma skin cancer, and gastric cancer are the most prevalent cancer forms in Kemerovo Region, with no differences in cancer mortality between 2001-2005(Kutikhin et al, 2012.…”

Analysis on the Characteristics and Prognosis of Pulmonary Neuroendocrine Tumors

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Increased UGT1A3 and UGT1A7 Expression is Associated with Pancreatic Cancer

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