Incidence and Risk Factors for Metabolic Syndrome in Korean Male Workers, Ages 30 to 39

Ryu, Seungho; Song, Jaechul; Choi, Bo-Youl; Lee, Soo-Jin; Kim, Won Sool; Chang, Yoosoo; Kim, Dong Il; Suh, Byung-Seong; Sung, Ki Chul

doi:10.1016/j.annepidem.2006.10.001

Cited by 84 publications

(69 citation statements)

References 25 publications

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“…2017; 19 (7):e14934. 39 years was 53.47/1000 person-years that was lower than a Korean study carried out by Ryu et al In a Korean study, the unadjusted and the age-adjusted incidence density of MetS was 70.5 and 76.9/1000 person-years, respectively, which was higher than the current study on the same age group (26). The annual cumulative incidence rate in the current study was 5.6% in males and 5.8% in females that was higher than a Korean study (males, 2.8%; females, 4.2%) and also higher than a French study (males, 3.5%; females, 2.7%) (5,22).…”

Section: Discussioncontrasting

confidence: 54%

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The Incidence of Metabolic Syndrome and the Most Powerful Components as Predictors of Metabolic Syndrome in Central Iran: A 10-Year Follow-Up in a Cohort Study

Sarebanhassanabadi

Mirhosseini

Mirzaei

et al. 2017

Iran Red Crescent Med J

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Section: Discussioncontrasting

confidence: 54%

“…According to the definition of MetS, people, who have 3 of 5 components have been affected by MetS. Therefore, changing lifestyle is highly essential for the higher risk group (who have two components) rather than the lower risk group (who have none or one component) (4,5,21,26).…”

Section: Discussionmentioning

confidence: 99%

The Incidence of Metabolic Syndrome and the Most Powerful Components as Predictors of Metabolic Syndrome in Central Iran: A 10-Year Follow-Up in a Cohort Study

Sarebanhassanabadi

Mirhosseini

Mirzaei

et al. 2017

Iran Red Crescent Med J

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“…In addition, the serum UA concentration is higher in individuals who have higher numbers of MetS variables [13,15,18]. Despite some epidemiologic research demonstrating a positive relationship between serum UA levels and the prevalence of MetS [19][20][21], prospective data on serum UA as predictor of MetS incidence are limited [22]. In fact, there is only one recent study from Korea which examined risk factors for incidence of MetS in young male workers ages 30 to 39 [22].…”

Section: Introductionmentioning

confidence: 98%

Uric acid and the development of metabolic syndrome in women and men

et al. 2008

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Associations between serum uric acid (UA) levels and metabolic syndrome (MetS) have been reported in cross-sectional studies. Limited information, however, is available concerning the prospective association of UA and risk of developing MetS. The authors evaluated UA as a risk factor for incident MetS in a prospective study of 8,429 men and 1,260 women (ages 20-82 years) who were free of MetS and for whom measures of waist girth, resting blood pressure, fasting lipids and glucose were taken during baseline and follow-up examinations between 1977 and 2003. Hyperuricemia was defined as >7.0 mg/dL in men and >6.0 mg/dL in women. MetS was defined with NCEP ATP III criteria. The overall prevalence of hyperuricemia was 17%. During a mean follow-up of 5.7 years, 1120 men and 44 women developed MetS. Men with serum UA concentrations ≥6.5 mg/dL (upper third) had a 1.60-fold increase in risk of MetS (95% confidence interval [CI]: 1.34-1.91), as compared with those who had concentrations <5.5 mg/dL (lowest third). Among women, the risk of MetS was at least 2-fold higher for serum UA concentrations ≥4.6 mg/ dL (p for trend=0.02). Higher serum UA is a strong and independent predictor of incident MetS in men and women.

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“…Hyperuricemia is common in diabetic and CKD patients. Elevated serum uric acid level is reported to be a risk factor for metabolic syndrome [20,21] and end-stage kidney disease [22]. Although homocysteine and uric acid possess many similarities, the relationships between homocysteine, uric acid, and eGFR are not clear in diabetic patients; few studies have investigated both homocysteine and uric acid levels in the same diabetic patients while focusing on renal function.…”

Section: Introductionmentioning

confidence: 99%

Hyperhomocysteinemia and Hyperuricemia are Closely Associated with a Decline in Renal Function in Patients with Type 2 Diabetes

Tanaka¹,

Nishimura²,

Itoh³

2017

J Diabetes Metab

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Objective: This study examined the association of homocysteine and uric acid with estimated glomerular filtration rate (eGFR) and explored their pathophysiological significance in patients with type 2 diabetes mellitus. Methods:We performed a cross-sectional study in 56 Japanese patients with type 2 diabetes. The correlations of serum total homocysteine level with age, diabetes duration, HbA1c, body mass index, systolic blood pressure, eGFR, urinary albumin-to-creatine ratio (ACR), and uric acid were investigated. The correlation between eGFR and uric acid was also investigated. Serum total homocysteine level was compared in men and women, as well as in patients with and without diabetic nephropathy, hypertension, smoking, and alcohol consumption. Stepwise multiple regression analyses were performed to identify explanatory factors for eGFR, total homocysteine, and uric acid. Results:Serum total homocysteine level showed a significant positive correlation with diabetes duration, ACR, and uric acid, and an inverse correlation with eGFR. Uric acid level and eGFR showed a significant inverse correlation. Patients with diabetic nephropathy and hypertension showed a significantly higher total homocysteine level. Multiple regression analyses demonstrated that age, total homocysteine, and uric acid were independent determinants of eGFR, and that age and eGFR were independent determinants of both total homocysteine and uric acid levels. Conclusion:Although total homocysteine, uric acid, and eGFR showed correlations, the relationship between uric acid and homocysteine might be weaker than that between eGFR and homocysteine, and between eGFR and uric acid. A relatively weak association between hyperuricemia and hyperhomocysteinemia observed in our study suggests confounding by decreased renal function. Both total homocysteine and uric acid can be used as biomarkers of renal dysfunction in patients with type 2 diabetes.

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Incidence and Risk Factors for Metabolic Syndrome in Korean Male Workers, Ages 30 to 39

Cited by 84 publications

References 25 publications

The Incidence of Metabolic Syndrome and the Most Powerful Components as Predictors of Metabolic Syndrome in Central Iran: A 10-Year Follow-Up in a Cohort Study

The Incidence of Metabolic Syndrome and the Most Powerful Components as Predictors of Metabolic Syndrome in Central Iran: A 10-Year Follow-Up in a Cohort Study

Uric acid and the development of metabolic syndrome in women and men

Hyperhomocysteinemia and Hyperuricemia are Closely Associated with a Decline in Renal Function in Patients with Type 2 Diabetes

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