Incidence and predictive factors for developing vesicoureteric reflux in individuals with suprasarcral spinal cord injury: a historical cohort study

Sirasaporn, Patpiya; Saengsuwan, Jiamjit

doi:10.1038/s41393-020-00573-6

Cited by 9 publications

(4 citation statements)

References 34 publications

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“…11 As there are no data on the prevalence of asymptomatic VUR in the adult population available we cannot infer whether VUR was preexistent or a short-term consequence of high pDetmax and indwelling urethral catheterization, both identified as predictive factors for VUR. 22 In our patients the prevalence of VUR decreased over time, which can be interpreted as a result of lowering pDetmax by use of antimuscarinic medication or intradetrusor onabo-tulinumtoxinA injections. The prevalence of low-compliance bladder in the SCI population was found to be about 17% in longterm follow-up studies.…”

Section: Findings In Context Of Existing Evidencementioning

confidence: 50%

“…21 A study assessing the incidence of VUR in patients with suprasacral SCI found an overall incidence of VUR of 7.5 cases per 100 person-years, which is similar to our findings of 7% within the first year after SCI. 22 Of note is that VUR was already present in 5% of our patients at 1 month after SCI. The aforementioned study by Bywater et al detected a similar rate for VUR in the acute phase.…”

Section: Findings In Context Of Existing Evidencementioning

confidence: 63%

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Neurogenic Lower Urinary Tract Dysfunction in the First Year After Spinal Cord Injury: A Descriptive Study of Urodynamic Findings

et al. 2023

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Purpose: We aimed to provide a real-world description of neurogenic lower urinary tract dysfunction within the first year after spinal cord injury with a focus on unfavorable urodynamic parameters that are associated with urological morbidity. Materials and Methods: Urodynamic investigations from 97 patients with traumatic or ischemic acute spinal cord injury and managed according to the European Association of Urology Guidelines on Neuro-Urology were analyzed at a single university spinal cord injury center at 1 month, 3 months, 6 months, and 12 months after injury. Unfavorable urodynamic parameters were defined as detrusor overactivity in combination with detrusor sphincter dyssynergia, maximum storage detrusor pressure of 40 cm H 2 O or higher, bladder compliance less than 20 mL/cm H 2 O, and vesicoureteral reflux of any grade. Results: One or more unfavorable urodynamic parameter was observed in 87 out of 97 patients (90%) within the first year after spinal cord injury. Eighty-eight percent of the patients showed detrusor overactivity with detrusor sphincter dyssynergia, 39% a maximum storage detrusor pressure of 40 cm H 2 O or higher, and 7% vesicoureteral reflux. No patient developed a low-compliance bladder. Conclusions: Using a standardized urodynamic follow-up schedule, we found unfavorable urodynamic parameters in a majority of the population within the first year after spinal cord injury. As early treatment based on urodynamic findings might reduce the risk of deterioration of upper and lower urinary tract function, thereby improving long-term outcomes, there is need for further research regarding recommendations for a urodynamic follow-up schedule during the first year after spinal cord injury.

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Section: Findings In Context Of Existing Evidencementioning

confidence: 50%

Section: Findings In Context Of Existing Evidencementioning

confidence: 63%

Neurogenic Lower Urinary Tract Dysfunction in the First Year After Spinal Cord Injury: A Descriptive Study of Urodynamic Findings

et al. 2023

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“…Given the paucity of longitudinal urodynamic data in patients with MCS/UWS, at the present time, one can only refer to other entities of NLUTD, such as SCI and MS, regarding the risk of developing VUR long-term. While Sirasaporn and Saengsuwan [ 35 ] reported an overall low incidence (i.e., 7.5 cases per 100 person-years) in a historical study comprising individuals with chronic SCI, Piquet et al [ 36 ] also reported a low prevalence (i.e., 5.5%) in individuals with MS.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Unfavorable Video-Urodynamic Findings and Clinical Implications in Patients with Minimally Conscious State/Unresponsive Wakefulness Syndrome: A Retrospective Descriptive Analysis

Leboutte,

Engesser,

Zahiti

et al. 2023

Biomedicines

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The aim of this retrospective exploratory study was to investigate the prevalence of unfavorable findings during video-urodynamic studies (VUDS) in patients with minimally conscious state (MCS)/unresponsive wakefulness syndrome (UWS) and whether management of the lower urinary tract (LUT) was adjusted accordingly. A retrospective chart review was conducted to screen for patients diagnosed with MCS/UWS at our rehabilitation center between 2011 and 2020. Patients 18 years or older were included and underwent baseline VUDS after being diagnosed with MCS/UWS. We analyzed urodynamic parameters and subsequent changes in LUT management in this cohort. In total, 32 patients (7 females, 25 males, median age 37 years) with MCS/UWS were included for analysis. While at least one unfavorable VUDS finding (i.e., neurogenic detrusor overactivity [NDO], detrusor sphincter dyssynergia {DSD, high maximum detrusor pressure during storage phase [>40 cmH2O], low-compliance bladder [<20 mL/cmH2O], and vesico–uretero–renal reflux [VUR]) was found in each patient, NDO (78.1%, 25/32) and DSD (68.8%, 22/32) were the two most frequent unfavorable VUDS findings. Following baseline VUDS, new LUT treatment options were established in 56.3% (18/32) of all patients. In addition, bladder-emptying methods were changed in 46.9% (15/32) of all patients, resulting in fewer patients relying on indwelling catheters. Our retrospective exploratory study revealed a high prevalence of NDO and DSD in patients with MCS/UWS, illustrating the importance of VUDS to adapt LUT management in this cohort accordingly.

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“…Upper urinary tract damage was a major cause for morbidity and mortality in patients with SCI till a few decades ago. In a retrospective study of patients with SCI reporting LUT symptoms, spanning 20 years, the incidence of vesico-ureteric reflux was 7.5 cases per 100 person-years [20]. High maximum detrusor pressure, indwelling urethral catheterization, age ≥60 years and absence of antimuscarinic drug use were predictive factors for vesico-ureteric reflux.…”

Section: Clinical Presentationmentioning

confidence: 98%

Urogenital dysfunction following neurotrauma

Saraf

Panicker

2022

Current Opinion in Neurology

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Purpose of reviewTrauma affecting the nervous system can have widespread consequences, depending on the location and severity of injury. The sensorimotor and cognitive deficits due to neurotrauma have been studied extensively. Although the overall mortality due to neurotrauma has reduced, the disability and morbidity due to neurotrauma has not significantly reduced and focus on urogenital disturbances in these patients has been limited. This article reviews the limited evidence and scientific literature on this topic. Recent findingsLower urinary tract symptoms are commonly reported in patients with neurotrauma, both acutely and over the long term. Multiple medical and surgical approaches are available for managing bladder dysfunction in these patients. Sexual dysfunction and changes in sexual behaviour are reported by patients with neurotrauma and are usually multifactorial. Treatment options for sexual dysfunction are available and their management requires a holistic approach. SummaryUrogenital dysfunction contributes significantly to the overall functional outcome and impaired quality of life in patients with neurotrauma. A better understanding of the mechanisms behind the urogenital abnormalities is needed for efficient management and treatment.

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Incidence and predictive factors for developing vesicoureteric reflux in individuals with suprasarcral spinal cord injury: a historical cohort study

Cited by 9 publications

References 34 publications

Neurogenic Lower Urinary Tract Dysfunction in the First Year After Spinal Cord Injury: A Descriptive Study of Urodynamic Findings

Neurogenic Lower Urinary Tract Dysfunction in the First Year After Spinal Cord Injury: A Descriptive Study of Urodynamic Findings

Prevalence of Unfavorable Video-Urodynamic Findings and Clinical Implications in Patients with Minimally Conscious State/Unresponsive Wakefulness Syndrome: A Retrospective Descriptive Analysis

Urogenital dysfunction following neurotrauma

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