“…The activation loop in the crystal structure is exposed and would allow proteolytic cleavage to allow the lectin domain to mediate uptake of the catalytic domain into the target cell in a manner typical of this class of toxin. Although the target(s) of Mtx1 in mosquito cells are unknown, Mtx1 modifies unknown target proteins in Culex quinquefasciatus (Thanabalu et al, 1993), several proteins in HeLa cells, EF-Tu in E. coli (Schirmer et al, 2002b) and soybean trypsin inhibitor, apparently targeting arginine residues for modification (Carpusca et al, 2006;Schirmer et al, 2002a). However, the kinetics of this reaction with respect to (Treiber et al, 2008).…”