Inactivation kinetics of waterborne virus by ozone determined by a continuous quench flow system

Torii, Shotaro; Itamochi, Masae; Katayama, Hiroyuki

doi:10.1016/j.watres.2020.116291

Cited by 30 publications

(25 citation statements)

References 44 publications

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“…Inactivation of the AMRB and AMSB by O 3 -based AOPs followed pseudo-first-order kinetics, as previously reported for O 3 disinfection of multiple bacteria and viruses [47,48,79,97]. CRE, MDRP, and VRE were rapidly inactivated >99% after 2 min; and ESBL-E and MDRA were inactivated >99% after 5 min in O 3 /H 2 O 2 treatment.…”

Section: Occurrence Of Amrb and Amsb In The Stp Wastewatersupporting

confidence: 80%

Inactivation of Antibiotic-Resistant Bacteria in Wastewater by Ozone-Based Advanced Water Treatment Processes

2022

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The inactivating effect of ozone (O3)-based advanced oxidation processes (AOPs) (O3/H2O2, O3/UV, and O3/UV/H2O2 systems) on antimicrobial-resistant bacteria (AMRB) and antimicrobial-susceptible bacteria (AMSB) in sewage treatment plant (STP) wastewater was investigated. The AMRB were grouped into six classes: carbapenem-resistant Enterobacteriaceae (CRE), extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E), multidrug-resistant Acinetobacter (MDRA), multidrug-resistant Pseudomonas aeruginosa (MDRP), methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococcus (VRE); these classes constituted the World Health Organization (WHO) global priority list of AMRB. The results indicate that O3-based advanced wastewater treatment inactivated all AMRB and AMSB (>99.9%) after 10 min of treatment, and significant differences (p < 0.5) were not observed in the disinfection of AMRB and AMSB by each treatment. Altered taxonomic diversity of micro-organisms based on 16S rRNA gene sequencing via O3/UV and O3/UV/H2O2 treatment showed that advanced wastewater treatments not only inactivated AMRB but also removed antimicrobial resistance genes (AMRGs) in the wastewater. Consequently, this study recommends the use of advanced wastewater treatments for treating the STP effluent, reducing environmental pollution, and alleviating the potential hazard to human health caused by AMRB, AMSB, and infectious diseases. Overall, this study provides a new method for assessing environmental risks associated with the spread of AMRB and AMSB in aquatic environments, while keeping the water environment safe and maintaining human health.

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Section: Occurrence Of Amrb and Amsb In The Stp Wastewatersupporting

confidence: 80%

Inactivation of Antibiotic-Resistant Bacteria in Wastewater by Ozone-Based Advanced Water Treatment Processes

2022

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“…Therefore, it can be concluded that these three factors, composition, structure and function, dictate the mechanisms of virus disinfection by ozone. Any difference in any of these factors, even if viruses that belong to the same species, and only differ in their strain, may lead to different disinfection mechanisms and therefore different susceptibility to ozone ( Hirneisen et al, 2010 , Meister et al, 2018 , Roy et al, 1982 , Sigstam et al, 2013 , Torii et al, 2020 , Wigginton and Kohn, 2012 , Wolf et al, 2018 ). In addition, the contribution of secondary reactive species generated as a consequence of direct ozone reactions with chemical subunits, and the potential for viral damage repair (by taking advantage of host repair enzymes, for example), may also play a role in the inactivation mechanism ( Kim et al, 1980 , Mayer et al, 2015 , Shinriki et al, 1988 , von Sonntag and von Gunten, 2012 ).…”

Section: Virus Inactivation By Ozonementioning

confidence: 99%

Can ozone inactivate SARS-CoV-2? A review of mechanisms and performance on viruses

Bayarri

Cruz-Alcalde

López-Vinent

et al. 2021

Journal of Hazardous Materials

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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has challenged societies around the globe. Technologies based on ozone, a powerful oxidant, have been evaluated to inactivate this virus in aerosols and fomites. However, the high data diversity hinders the possibility of establishing a common ground for determining best practices for the use of these technologies. Furthermore, there is a lack of consensus regarding which are the main mechanisms of ozone virus inactivation. This critical review examined the most relevant information available regarding ozone application in gas-phase for different viruses inactivation (including recent publications dealing with SARS-CoV-2), and pointed towards envelope alteration as the main reaction pathway for enveloped viruses, such as is the case of SARS-CoV-2. It could also be concluded that gaseous ozone can be indeed an effective disinfectant, successfully inactivating viruses such us influenza A H1N1, MERS-CoV, SARS-CoV-1 or even SARS-CoV-2 in aerosols or fomites. In reviewed works, low ozone exposures, just around 0.1-0.4 mg L -1 min, achieve about 4 log 10 of inactivation in aerosols, while exposures between 1 and 4 mg L -1 min may be needed to guarantee an inactivation of 3-4 log 10 in different fomites. Although further studies are required, ozone is an effective candidate to be used against SARS-CoV-2 or other viruses in surfaces and indoor locations.

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“…Temperature and pH have been shown to have negligible effect on ozone inactivation kinetics (Katzenelson, Kletter, and Shuval 1974;Sigmon et al 2015;Wolf, von Gunten, and Kohn 2018). Additionally, multiple studies have indicated that the USEPA drinking water regulation is conservative, with ozone efficacy for virus inactivation substantially exceeding CT guidelines (Thurston-Enriquez et al 2005;Torii, Itamochi, and Katayama 2020). Overall, these results indicate that ozone is likely to be highly effective at inactivating SARS-CoV-2 in water, if necessary.…”

Section: Water Treatmentmentioning

confidence: 95%

Critical Review and Research Needs of Ozone Applications Related to Virus Inactivation: Potential Implications for SARS-CoV-2

Morrison

Atkinson

Zamyadi

et al. 2020

Ozone: Science & Engineering

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Ozone disinfection has demonstrated high efficacy against enveloped and non-enveloped viruses, including viruses similar in morphology to SARS-CoV-2. Due to this efficacy, numerous gaseous and aqueous phase ozone applications have emerged to potentially inhibit virus persistence in aerosols, surfaces, and water. This review identifies the exposure requirements for virus inactivation and important safety considerations for applications within the built environment (i.e. occupied/unoccupied spaces, air/water/wastewater treatment) and healthcare settings (i.e. ozone therapy, dentistry, handwashing, treatment of personal protection equipment (PPE)). Current research needs are presented to advance the utilization of ozone as a mitigation strategy.

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Inactivation kinetics of waterborne virus by ozone determined by a continuous quench flow system

Cited by 30 publications

References 44 publications

Inactivation of Antibiotic-Resistant Bacteria in Wastewater by Ozone-Based Advanced Water Treatment Processes

Inactivation of Antibiotic-Resistant Bacteria in Wastewater by Ozone-Based Advanced Water Treatment Processes

Can ozone inactivate SARS-CoV-2? A review of mechanisms and performance on viruses

Critical Review and Research Needs of Ozone Applications Related to Virus Inactivation: Potential Implications for SARS-CoV-2

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