2019
DOI: 10.1038/s41598-019-50683-2
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Abstract: Nano-emulsions are promising carriers for antigen delivery. Here, we evaluated the efficacy of a water-oil nano-emulsion containing concentrated, inactivated Clostridium novyi (C. novyi) type B supernatant culture (nano-iCnB) in protecting Swiss mice against a lethal dose of alpha toxin concentrated extract. Proteins were confirmed in the nano-iCnB and their stabilities were determined according physical parameters such as Zeta Potential (ZP). Biochemical, hematological parameters and morphological appearance … Show more

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Cited by 6 publications
(10 citation statements)
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“…Nonqualified persons at community pharmacies/medical stores are involved in unethical sale practices and destroying the youth of nation. Only 5 per cent of more than 40,000 pharmacies in Pakistan have qualified pharmacists while around 15,000 qualified pharmacists are jobless and an overwhelming number of the medical stores are run by unqualified managers (Felix et al, 2019). There is need for strict regulatory measures against such pharmacies/drug store to overcome the menace of drugs in Pakistan.…”
Section: Discussionmentioning
confidence: 99%
“…Nonqualified persons at community pharmacies/medical stores are involved in unethical sale practices and destroying the youth of nation. Only 5 per cent of more than 40,000 pharmacies in Pakistan have qualified pharmacists while around 15,000 qualified pharmacists are jobless and an overwhelming number of the medical stores are run by unqualified managers (Felix et al, 2019). There is need for strict regulatory measures against such pharmacies/drug store to overcome the menace of drugs in Pakistan.…”
Section: Discussionmentioning
confidence: 99%
“…Every effort was made to avoid suffering or undue pain; the mice were monitored for weight loss and gain and clinical manifestations such as lethargy, hypothermia, and difficulty breathing. The animals were euthanized using ketamine (300 mg/kg) (Vetbrands ® , Rio de Janeiro, Brazil) and xylazine hydrochloride (22.5 mg/kg) (Syntec ® , Piracicaba, Brazil) [ 17 , 18 , 19 ].…”
Section: Methodsmentioning
confidence: 99%
“…Murine models of sepsis and pneumonia caused by A. baumannii are thought to contribute to the understanding of the pathogenesis and the dynamics of the host response because these animals develop acute infections with pathological changes; they can therefore be used for the elaboration of new infection protocols and vaccine quality control and for the development of pharmacological interventions [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ].…”
Section: Introductionmentioning
confidence: 99%
“…Necropsies of the liver, spleen, and other part of the body were also examined to determine the safety of the vaccine. Data suggested that the nanovaccine was efficient for promoting antigen delivery and protection against lethal doses of bacteria in immunized mice (Felix et al 2019). The effect of chitosan nanoparticles has been studied on the efficiency of clostridial vaccines.…”
Section: Nanovaccinesmentioning
confidence: 99%