In169, A New Class 1 Integron that Encoded blaIMP-18 in a Multidrug-Resistant Pseudomonas aeruginosa Isolate from Mexico

Two Novel Class I Integron Arrays Containing IMP-18 Metallo-β-Lactamase Gene in Pseudomonas aeruginosa Clinical Isolates from Puerto Rico

“…The location of bla in the first position in both integrons is similar to In96 and In169, but different from In133. The bla has been previously associated with bla OXA-2 in the In169 class I integron identified in Mexico, which harbors two copies of the aadA1 gene cassette in the second and fourth positions with the bla OXA-2 gene between them (14). In In706, the bla OXA-2 gene was also identified in the third position as in In169, but with other gene cassettes.…”

“…The sizes of the class I integrons sequenced were 4,378 bp for In706 and 3,668 bp for In707, and their structures were compared to the three previously described P. aeruginosa-containing bla integrons isolated in Mexico (In96 and In169) and the United States (In133) (1,3,14). The location of bla in the first position in both integrons is similar to In96 and In169, but different from In133.…”

“…The structure of the variable region of the class I integron containing the IMP-18 gene cassette was determined as previously described by Sánchez-Martínez et al (14). All PCR amplicons generated were sequenced independently and bidirectionally at least twice.…”

Widespread of ESBL- and carbapenemase GES-type genes on carbapenem-resistant Pseudomonas aeruginosa clinical isolates: a multicenter study in Mexican hospitals

“…Studies carried out in recent years in Mexico have provided evidence that metallo-β-lactamases (MβLs) IMP-15, IMP-18, and VIM-2 and class A carbapenemase GES-20 and extended spectrum β-lactamases (ESBLs) SHV-, CTX-M-type, TLA-1, and GES-19 are the most prevalent β-lactamases among Pseudomonas aeruginosa and Enterobacteriaceae clinical isolates, respectively (Barrios et al, 2012;Garza-Ramos et al, 2008a, 2008bSanchez-Martinez et al, 2010;Silva-Sanchez et al, 2011a, 2011b. In Spain and Mexico, the GES-type tandem gene duplication was identified recently on P. aeruginosa and Enterobacteriaceae clinical isolates, respectively (Barrios et al, 2012;Viedma et al, 2009).…”

La evolución de la resistencia bacteriana en México, 1973-2013

“…Otra publicación informa del hallazgo en aislamientos provenientes de la Ciudad de México de los genes IMP-15 y VIM-2. Asimismo, en un paciente con fibrosis quística se encontró P. aeruginosa productoras de las betalactamasas OXA 141 (42)(43)(44)(45)(46)(47)(48)(49).…”