In vivo tracking of stem cells in brain and spinal cord injury

Syková, Eva; Jendelová, Pavla

doi:10.1016/s0079-6123(06)61026-1

Cited by 139 publications

(101 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Functional improvements may be observed whatever the implantation route, intravenously or intracerebrally, even if reduction in infarct volume is not always observed (Li et al, 2000). This underlines the capacity of MSCs to migrate towards lesions, as was already observed by other groups www.intechopen.com Advances in the Combined Use of Adult Cell Therapy and Scaffolds for Brain Tissue Engineering 381 (Chen et al, 2001) after IV injection, or after intracerebral graft in a lesioned rat brain (Sykova & Jendelova, 2007;Delcroix et al, 2009). Noteworthy, in situ neural or neuronal differentiation of transplanted MSCs has been described in several studies.…”

Section: Adult Cells For Cerebral Ischemia and Traumatic Brain Injurymentioning

confidence: 63%

Advances in the Combined Use of Adult Cell Therapy and Scaffolds for Brain Tissue Engineering

Garbayo¹,

Delcroix²,

Schiller³

et al. 2011

Tissue Engineering for Tissue and Organ Regeneration

View full text Add to dashboard Cite

Section: Adult Cells For Cerebral Ischemia and Traumatic Brain Injurymentioning

confidence: 63%

Advances in the Combined Use of Adult Cell Therapy and Scaffolds for Brain Tissue Engineering

Garbayo¹,

Delcroix²,

Schiller³

et al. 2011

Tissue Engineering for Tissue and Organ Regeneration

View full text Add to dashboard Cite

“…Cell survival, distribution, migration, and differentiation in vivo can be assessed through various tools. In recent years, the tracking of cells in living organisms has become possible to measure non-invasively through cellular magnetic resonance imaging (Jirjis et al, 2017;Shroff, 2017;Sykova et al, 2007). Once the safety and efficacy have been demonstrated in in vitro and in vivo, clinical trials for application to individuals with SCI are currently available.…”

Section: Cell-based Interventionsmentioning

confidence: 99%

Current Therapeutic Approaches in Spinal Cord Injury: Pharmacological, Rehabilitation, Cell-based, and Psychological Intervention

Lim

Choi

2017

Korean J Str Res

View full text Add to dashboard Cite

The purpose of this review is to discuss current therapeutic interventions and their limitations for the optimal treatment outcomes of individuals with spinal cord injury (SCI). SCI leads to neurologic deficits and subsequent severe muscle atrophy. In clinics, despite the controversy, pharmacological therapy using methylprednisolone has widely been accepted to reduce additional neurologic deficits caused by a secondary injury such as oxidative stress and lipid peroxidation. Moreover, it facilitates the recovery process. Since the loss of locomotor function may reduce the quality of life for individuals with SCI, many pre-clinical and clinical studies have focused on the recovery of locomotor function. Various forms of locomotor training such as treadmill training, cycle training, and robotic-assisted training are currently available for individuals with SCI. Additionally the cell-based interventions have been receiving much attention as one of potential therapeutic interventions which required further clarifications due to the issues of safety. The physical impairment associated with spinal cord injury may cause an adverse effect on mental health. It is now recommended that combined physical and psychological interventions should be considered to maximize the efficacy of therapeutic interventions.

show abstract

“…Excellent reviews on the different imaging modalities are available (Sykova & Jendelova, 2007;Gera et al, 2010). SPECT imaging with indium oxine ( 111 In-oxine) offers an efficient method to study the whole body biodistribution of cells in stroke models (Figure 1).…”

Section: Effect Of Administration Routementioning

confidence: 99%