2016
DOI: 10.3389/fphys.2016.00187
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Abstract: Sarcomere lengths have been a crucial outcome measure for understanding and explaining basic muscle properties and muscle function. Sarcomere lengths for a given muscle are typically measured at a single spot, often in the mid-belly of the muscle, and at a given muscle length. It is then assumed implicitly that the sarcomere length measured at this single spot represents the sarcomere lengths at other locations within the muscle, and force-length, force-velocity, and power-velocity properties of muscles are of… Show more

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Cited by 74 publications
(85 citation statements)
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“…A recently developed probe capable of measuring thousands of sarcomeres in vivo (Young et al, 2017) offers a promising alternative to mechanical transducers and may help resolve the problems of modeling single muscle force from sarcomere length during non-isometric and submaximal activity. However, multiple such probes will be necessary given that fiber and sarcomere strain are heterogeneous throughout the muscle (Ahn et al, 2003;Konow et al, 2010;Wentzel et al, 2011;Holman et al, 2012;Moo et al, 2016;O'Connor et al, 2016).…”
Section: Capturing Muscle Kinematics and Kineticsmentioning
confidence: 99%
See 1 more Smart Citation
“…A recently developed probe capable of measuring thousands of sarcomeres in vivo (Young et al, 2017) offers a promising alternative to mechanical transducers and may help resolve the problems of modeling single muscle force from sarcomere length during non-isometric and submaximal activity. However, multiple such probes will be necessary given that fiber and sarcomere strain are heterogeneous throughout the muscle (Ahn et al, 2003;Konow et al, 2010;Wentzel et al, 2011;Holman et al, 2012;Moo et al, 2016;O'Connor et al, 2016).…”
Section: Capturing Muscle Kinematics and Kineticsmentioning
confidence: 99%
“…The whole muscle and whole fiber lengths estimated using our method do not provide information on sarcomere length dynamics, which impairs our ability to estimate muscle force. Fascicles and sarcomeres exhibit strain heterogeneity, the functional consequences of which are unclear (Ahn et al, 2003;Konow et al, 2010;Wentzel et al, 2011;Holman et al, 2012;O'Connor et al, 2016;Moo et al, 2016). Muscle morphology may contribute to strain heterogeneity, as the more peripheral fibers in fusiform muscles may have different strain patterns than more central fibers (Pappas et al, 2002;Blemker et al, 2005;Zatsiorsky and Prilutsky, 2012).…”
Section: Limitationsmentioning
confidence: 99%
“…Second harmonic generation imaging techniques were used to visualize the fibre striation pattern in mutant (n=9) and control (n=4) fibres (Moo et al, 2016), isolated from a single mutant and control psoas muscle. Two photon excitation imaging techniques were used to visualize the nuclei of the fibres.…”
Section: Fibre Imagingmentioning
confidence: 99%
“…Furthermore, we seldom know what proportion of maximum force capability is represented by muscle activation during a biologically significant action if that action is not amenable to experimental testing. Additional issues include heterogeneity of fiber activation and fiber length within a muscle which might produce erroneous estimates of muscle force, delay in the signal of activation, and issues related to the relationship between force and velocity (Ahn et al, ; German et al, ; Konow et al, ; Wentzel et al, ; Holman et al, ; O'Connor et al, ; Moo et al, ). Another unknown is the relative contribution of the passive components of muscle tissue (e.g., tendon, aponeurosis, etc.)…”
Section: Outstanding Questions (The Known Unknowns)mentioning
confidence: 99%