Cell Reports volume 11, issue 11, P1714-1726 2015 DOI: 10.1016/j.celrep.2015.05.032 View Full Text
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Asiel A. Benitez, Maryline Panis, Jia Xue, Andrew Varble, Jaehee V. Shim, Amy L. Frick, Carolina B. López, David Sachs, Benjamin R. tenOever

Abstract: SUMMARY Responding to an influenza A virus (IAV) infection demands an effective intrinsic cellular defense strategy to slow replication. To identify contributing host factors to this defense, we exploited the host microRNA pathway to perform an in vivo RNAi screen. To this end, IAV, lacking a functional NS1 antagonist, was engineered to encode individual siRNAs against antiviral host genes in an effort to rescue attenuation. This screening platform resulted in the enrichment of strains targeting virus-activat…

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