In vivo protective effect of dietary curcumin in fish Anabas testudineus (Bloch)

Abstract

The present study describes, for the first time, the protective effect of natural curcumin in vivo in a lower vertebrate, a teleost, Anabas testudineus (Bloch). Two doses of curcumin 0.5 and 1% were supplemented in the 40% protein feed and fed to fish for the periods, 2 and 8 weeks. The antioxidant status, protein content, and the tissue structure in experimental fish were examined after the short-term and long-term feeding. In all the curcumin fed groups, the lipid peroxidation product, thiobarbituric acid reactive substances content either decreased or unaffected. The glutathione content increased while the antioxidant enzyme activity pattern varied with time and dose. The histological analysis also confirmed the safety of curcumin retaining the normal arrangement of hepatocytes, hepatopancreas, macrophage-melanocyte centers in Anabas. The improved antioxidant status and protein content suggest a favorable effect for curcumin in cultured fish.

Untitled

“…In the present study, fish fed the high dose of curcumin (20 g/kg diet) exhibited degeneration vacuoles in hepatocytes and large accumulation of hemosiderin around blood vessels (T6, 1f). That disagrees with the study by Manju (2012) who, reported that in the curcumin-treated Anabas sp., there were no histological changes in the liver after feeding two doses of curcumin at 5 and 10 g/kg.…”

Combined antiparasitic and anti‐inflammatory effects of the natural polyphenol curcumin on turbot scuticociliatosis

“…Similar results have been obtained in other fish such as Jian carp (Cyprinus carpio var. Jian) and Nile tilapia (Oreochromis niloticus), in which treatment with curcumin reduced the proinflammatory cytokine expression levels to normal (Cao et al 2015;Mahfouz 2015) and had positive effects in cultured fish (Manju et al 2012).…”

“…The safety profile of CUR has so far been found to be excellent (Clarke & Mullin ; He et al . ), and the compound has shown positive effects on growth of fish in aquaculture (Manju, Akbarsha & Oommen ; Manju et al . ; Mahfouz ).…”

“…Furthermore, CUR has been reported to inhibit the host NFjB signalling pathway, which is activated during several parasite infections and interferes in inflammation and oxidative stress (Haddad, Sauvain & Deharo 2011;Cao et al 2015). The safety profile of CUR has so far been found to be excellent (Clarke & Mullin 2008;He et al 2015), and the compound has shown positive effects on growth of fish in aquaculture (Manju, Akbarsha & Oommen 2012;Manju et al 2013;Mahfouz 2015).…”

Improved vitellogenesis, gonad development and egg diameter in catfish (Pangasianodon hypophthalmus) supplemented with turmeric (Curcuma longa) powder

“…How do the curcumins contained in turmeric improve liver function and increase egg diameter? Turmeric and curcumin have been used as hepatoprotectors to prevent and cure liver damage (Manju, Akbarsha & Oommen, ). Turmeric has traditionally been used in Ayurveda and folk medicine to treat ailments, and modern science has provided the basis for its use in the treatment of liver disorders (Gupta et al., ).…”