In vivo photodynamic therapy with the new near-IR absorbing water soluble photosensitizer lutetium texaphyrin and a high intensity pulsed light delivery system

Kostenich, Genady; Orenstein, Arie; Roitman, Leonid; Malik, Zvi; Ehrenberg, Benjamin

doi:10.1016/s1011-1344(96)00005-x

Cited by 30 publications

(21 citation statements)

References 14 publications

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“…The present study is limited to four compounds: sulfonated chloro-aluminum phthalocyanine (AlPcS n ) [14], benzoporphyrin derivative monoacid ring A (BPD-MA) [15,16], lutetium texaphyrin (Lutex) [17][18][19], and aminolevulinic acid (ALA), a precursor of the endogenous sensitizer protoporphyrin IX (PpIX) [20]. In Table 1 Thursday we present some published results of the PDT efficiency, relative to Photofrin, of these selected sensitizers [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Photodynamic parameters in the chick chorioallantoic membrane (CAM) bioassay for topically applied photosensitizers

Hammer‐Wilson

Akian

Espinoza

et al. 1999

Journal of Photochemistry and Photobiology B: Biology

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Section: Introductionmentioning

confidence: 99%

Photodynamic parameters in the chick chorioallantoic membrane (CAM) bioassay for topically applied photosensitizers

Hammer‐Wilson

Akian

Espinoza

et al. 1999

Journal of Photochemistry and Photobiology B: Biology

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“…Aside from diagnostic usage, porphyrin derivatives have also been developed as an agent for photodynamic therapy (CalzavaraPinton et al, 1996;Hill et al, 1996;Kessel, 1992;Kostenich et al, 1997;Lapes et al, 1996;McIlroy et al, 1998;Nakajima et al, 1998;Shopova et al, 1994;Takemura et al, 1992;Woodburn et al, 1998), radiation sensitizer (Rowinsky 1999;Viala et al, 1999) and an agent for neutron capture therapy (Matsumura et al, 1999;Miura et al, 1996;Shibata et al, 1998). This study revealed that the enhancement effect of the tumour demonstrated on the MR images was well correlated with the biodistribution of the HOP-9P (Figure 2, Table 1).…”

Section: Discussionmentioning

confidence: 99%

Tumour enhancement with newly developed Mn-metalloporphyrin (HOP-9P) in magnetic resonance imaging of mice

et al. 2001

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Discriminating between tumours and normal tissues non-invasively is one of the major goals of diagnostic MR imaging. Although tumours are often hypointense on T1-weighted images and hyperintense on T2-weighted images compared to normal tissues even without any contrast media, these findings are not consistently specific. Therefore, a tumour-specific MRI contrast agent remains important for improved detection of tumours, staging, and their characterization. Gadolinium chelates are now being used as the workhorse for detecting tumours in the clinical environment. These contrast media, however, are non-specific extravascular contrast agents. Gadolinium chelates are rapidly delivered to tumours depending on their vascular space, and stay in the tumour depending on the size of the extracellular compartment; however in the majority of the cases, they are rapidly washed out of the tumour. Therefore, the imaging windows for tumour depiction using gadolinium chelates have been quite narrow, and furthermore, the detection of hypovascular tumours has always been problematic with non-specific agents.Porphyrins were the first potentially tissue-specific MR contrast agents to be evaluated because of their ability to form stable chelate complexes with paramagnetic metal ions and their selective retention by tumours. Moreover, complexes containing manganese were identified as potentially the most useful ones because of the high relaxivity of this metal. 2, 4-bis (1-tetrahydro-fulfuroxyethyl)-deuteroporphynyl (IX)-6-7-bisaspartic acid (THF-Mn-ASP), a prototype of HOP-9P, has shown its tumour specific characteristics in a previous report (Suzuki et al, 1996). In this study we perform an initial evaluation of the recently developed HOP-9P as a new tumour seeking MR contrast media using mice in comparison to conventional gadolinium chelates. MATERIALS AND METHODS ChemicalsThe compound, 13, 17-bis (1-carboxypropionyl) carbamoylethyl-3, 8-bis (1-phenylpropyloxyethyl)-2, 7, 12, 18-tetramethyl-porphynato manganese (III) (HOP-9P) has a molecular weight of 1135. In this study, HOP-9P was dissolved with 0.1 M phosphate buffer (pH8.0), and gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) (Magnevist, Nihon Schering, Co. Ltd) was diluted with physiological saline before use. Phantom study for relaxivity measurementsThe relaxivity of HOP-9P was measured at 37˚C in 0.9% sodium chloride solution in a 50 ml polypropylene centrifuge tube using a 1.5T super-conductive imager (Magnetom SP, Siemens Medical Systems, Erlangen, Germany). Relaxivity of Gd-DTPA was also measured for comparison. The T1 relaxation times for each solutions were calculated using the spin echo sequence (SE) (TR of 400 and 2400 ms), with 15 ms of TE. A matrix of 256 × 256 and slice thickness of 8 mm were used for the T1 measurements. Summary The purpose of the study is to evaluate the tumour enhancing characteristics and biodistribution of a newly developed metalloporphyrin derivative, HOP-9P (13, 17-bis (1-carboxypropionyl) carbamoylethyl-3, 8-bis (1-phenylpropyloxyeth...

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“…Besides their usage in various imaging platforms, some of the NIR imaging agents are also used as a PS in PDT applications (32)(33)(34)(35). PDT is a promising non-invasive localized treatment modality for a diverse range of diseases, including various types of cancers, infections, and inflammatory conditions.…”

Section: Therapymentioning

confidence: 99%

Near-Infrared Dyes and Their Use in Medical Science

Erdem¹

2016

Clin Exp Health Sci

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Öz AbstractNear-IR (NIR) (yakın kızıl ötesi) floresan boyalarla hedefe yönelik görüntüle-me (tanı) ve tedavi imkânı, görüntülerin renk yansıması ve floresan emisyonundan alınan datalar yardımıyla gerçekleştirilir ve özellikle derin yüzeyde bulunan dokuların görüntülenmesinde önemli rol oynar. Bu moleküllerin soğurma ve floresans yaptıkları bölge NIR spektroskopisinin (NIRS) moleküler görüntülemelerdeki seçici alanı olarak tanımlanır (650-850 nm). NIR floresan boyalar genel olarak NIR görüntüleme içeren çalışmalarda kullanılmasına rağmen günümüzde fotodinamik tedavi de kendine yer bulmaktadırlar. Klinik öncesi araştırmalarda, ftalosiyanin, klorin, porfirin, bakterioklorin, siyanin, alexfluore ve çeşitli bodipy serileri vb. NIR floresan boyalar/ajanlar kullanıl-maktadır. Bu boyalardan özellikle görüntüleme çalışmalarında en öne çıkanı, diğer boyalara kıyasla ileri fotofiziksel ve kimyasal özelliklere sahip ftalosiyaninlerdir. NIR boyaların kullanılmasının mevcut ve potansiyel avantajlarının yanında bu boyaların toksisite sorunu boyaların klinikte kullanılmasını kısıt-lamaktadır. Klinikte kullanılan FDA onaylı tek boya indosiyanin yeşilidir ve ihmal edilebilir yan etkileriyle, kardiyak fonksiyonların kontrolü, karaciğer çık-tıları ve retinal anjiyografi gibi klinik alanlarda kullanılmaktadır. Sonuç olarak, birçok önemli sorunlar taşımakla birlikte günümüzde hala güvenli kullanıma uygun olmayan NIR boyaların yakın gelecekte bahsi geçen uygulamalarda uygun olarak kullanılabilecek kimyasal, fotokimyasal ve fotofiziksel özellikleri geliştirilmiş şekilde üretilmesi ihtiyacı kaçınılmazdır. Bununla beraber gelişti-rilmiş ve/veya geliştirilecek olan NIR floroforların nanopartiküler sistemlerle birleştirilerek ve/veya ajan moleküller ile hedef belirlenerek NIRS ve terapi yönünden daha avantajlı hale getirilmesi gereklidir.

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In vivo photodynamic therapy with the new near-IR absorbing water soluble photosensitizer lutetium texaphyrin and a high intensity pulsed light delivery system

Cited by 30 publications

References 14 publications

Photodynamic parameters in the chick chorioallantoic membrane (CAM) bioassay for topically applied photosensitizers

Photodynamic parameters in the chick chorioallantoic membrane (CAM) bioassay for topically applied photosensitizers

Tumour enhancement with newly developed Mn-metalloporphyrin (HOP-9P) in magnetic resonance imaging of mice

Near-Infrared Dyes and Their Use in Medical Science

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