In vivo photoacoustic imaging of vasculature with a low-cost miniature light emitting diode excitation

Dai, Xianjin; Yang, Hao; Jiang, Huabei

doi:10.1364/ol.42.001456

Cited by 50 publications

(41 citation statements)

References 19 publications

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“…Recently, pulsed laser diodes (PLDs) and light emitting diodes 4,17,18 have been reported as compact and less expensive alternatives for Nd:YAG lasers. High-frame rate (7000 fps) B-scan PA imaging was shown with PLDs using clinical ultrasound platform.…”

Section: Introductionmentioning

confidence: 99%

Dynamic in vivo imaging of small animal brain using pulsed laser diode-based photoacoustic tomography system

Upputuri

Pramanik

2017

J. Biomed. Opt

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We demonstrate dynamic in vivo imaging using a low-cost portable pulsed laser diode (PLD)-based photoacoustic tomography system. The system takes advantage of an 803-nm PLD having high-repetition rate ∼7000 Hz combined with a fast-scanning single-element ultrasound transducer leading to a 5 s cross-sectional imaging. Cortical vasculature is imaged in scan time of 5 s with high signal-to-noise ratio ∼48. To examine the ability for dynamic imaging, we monitored the fast uptake and clearance process of indocyanine green in the rat brain. The system will find applications to study neurofunctional activities, characterization of pharmacokinetic, and biodistribution profiles in the development process of drugs or imaging agents.

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Section: Introductionmentioning

confidence: 99%

Dynamic in vivo imaging of small animal brain using pulsed laser diode-based photoacoustic tomography system

Upputuri

Pramanik

2017

J. Biomed. Opt

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“…Moreover, although the absorption coefficient of hemoglobin is higher in 405 nm compared to 905 nm, available energies of NIR PLDs are higher than those in the visible range [5] , [43] , [45] . Light emitting diodes (LEDs) have also been reported as photoacoustic light sources [64] , [65] , however due to the larger divergence of LED beam compared to laser diodes, it is more challenging to obtain low-loss collimation and tight focusing of LED beam [65] . Moreover, PLDs can have shorter pulsewidths compared to LEDs, which leads to better axial resolution [65] .…”

Section: Discussionmentioning

confidence: 99%

Laser scanning laser diode photoacoustic microscopy system

2018

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The development of low-cost and fast photoacoustic microscopy systems enhances the clinical applicability of photoacoustic imaging systems. To this end, we present a laser scanning laser diode-based photoacoustic microscopy system. In this system, a 905 nm, 325 W maximum output peak power pulsed laser diode with 50 ns pulsewidth is utilized as the light source. A combination of aspheric and cylindrical lenses is used for collimation of the laser diode beam. Two galvanometer scanning mirrors steer the beam across a focusing aspheric lens. The lateral resolution of the system was measured to be ∼21 μm using edge spread function estimation. No averaging was performed during data acquisition. The imaging speed is ∼370 A-lines per second. Photoacoustic microscopy images of human hairs, ex vivo mouse ear, and ex vivo porcine ovary are presented to demonstrate the feasibility and potentials of the proposed system.

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“…Recently, in vivo tissue imaging has been proved for the¯rst time by LED-PAI. 91 In this study, a super-fast switching high-current LED driving circuit with a rise-time of 2.2 ns and a falltime of 3.5 ns operated at 200 ns pulses, a repetition rate of 40 kHz and provided 1.2 W output power at 405 nm. The LED-PAI system is schematically shown in Fig.…”

Section: Led-based Pai (Led-pai)mentioning

confidence: 99%

Low-cost photoacoustic imaging systems based on laser diode and light-emitting diode excitation

Yao

Ding

Liu

et al. 2017

J. Innov. Opt. Health Sci.

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Photoacoustic imaging, an emerging biomedical imaging modality, holds great promise for preclinical and clinical researches. It combines the high optical contrast and high ultrasound resolution by converting laser excitation into ultrasonic emission. In order to generate photoacoustic signal e±-ciently, bulky Q-switched solid-state laser systems are most commonly used as excitation sources and hence limit its commercialization. As an alternative, the miniaturized semiconductor laser system has the advantages of being inexpensive, compact, and robust, which makes a signi¯cant e®ect on production-forming design. It is also desirable to obtain a wavelength in a wide range from visible to nearinfrared spectrum for multispectral applications. Focussing on practical aspect, this paper reviews the state-of-the-art developments of low-cost photoacoustic system with laser diode and light-emitting diode excitation source and highlights a few representative installations in the past decade.

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In vivo photoacoustic imaging of vasculature with a low-cost miniature light emitting diode excitation

Cited by 50 publications

References 19 publications

Dynamic in vivo imaging of small animal brain using pulsed laser diode-based photoacoustic tomography system

Dynamic in vivo imaging of small animal brain using pulsed laser diode-based photoacoustic tomography system

Laser scanning laser diode photoacoustic microscopy system

Low-cost photoacoustic imaging systems based on laser diode and light-emitting diode excitation

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