In vivo measures of monoamines during amphetamine-induced behaviors in rats

Maternal high fat diet during the perinatal period alters mesocorticolimbic dopamine in the adult rat offspring: reduction in the behavioral responses to repeated amphetamine administration

“…Acute administration of psychostimulants such as AMP is known to increase extracellular DA content in several terminal fields containing DA and norepinephrine transporters (Kuczenski and Segal 1990;Sharp et al 1987). In particular, locomotor activation after acute AMP treatment correlates with the time course change and amount of DA released in the NAc core as demonstrated by microdialysis experiments (Sharp et al 1987;Corda et al 2006).…”

Maternal high fat diet during the perinatal period alters mesocorticolimbic dopamine in the adult rat offspring: reduction in the behavioral responses to repeated amphetamine administration

“…Acute administration of psychostimulants such as AMP is known to increase extracellular DA content in several terminal fields containing DA and norepinephrine transporters (Kuczenski and Segal 1990;Sharp et al 1987). In particular, locomotor activation after acute AMP treatment correlates with the time course change and amount of DA released in the NAc core as demonstrated by microdialysis experiments (Sharp et al 1987;Corda et al 2006).…”

Behavioral sensitization and extracellular dopamine responses to amphetamine after various treatments

“…We have previously shown that a test dose of AMPH or COC, administered at relatively short intervals after repeated single daily injections of the same dose of the stimulant, results in behavioral sensitization in the absence of a correspondingly enhanced extracellular DA response (Kuczenski and Segal 1990;Segal and Kuczenski 1992a,b). The present results extend this observation to AMPH treatment regimens which some investigators have suggested may facilitate the appearance of an increased DA response.…”

“…During the past several years, most investigators, using in vivo microdialysis methodologies, have reported that behavioral sensitization to AMPH-like stimulants is accompanied by an increased DA response in DA projection areas, including caudate-putamen (CP) and nucleus accumbens (NAC) (see, for example, Akimoto et al 1989;Kalivas and Duffy 1990;Patrick et al 1991;Keller Jr et al 1992;Parsons and Justice Jr 1993;Wolf et al 1993;Vezina 1993; see also Paulson and Robinson 1995, for a review). However, while these observations suggest that enhanced DA may underlie sensitization, we (Kuczenski and Segal 1990;Segal and Kuczenski 1992a,b) and others (see, for example Narahashi 1974;Hurd and Ungerstedt 1989;Hurd et al 1990;Unterwald et al 1994;Wolf et al 1994;Heidbreder et al 1996;Imperato et al 1996) have noted that behavioral sensitization to both AMPH and cocaine (COC) can be obtained in the absence of an enhanced DA response in either CP or NAC. In fact, Kalivas and Duffy (1993) observed sensitization to the locomotor effects of COC in the presence of an increase, a decrease, and no change in the extracellular DA response.…”

Neurobehavioral alterations in HIV-1 transgenic rats: Evidence for dopaminergic dysfunction

“…Previous studies have demonstrated that behavioral sensitization may be observed in response to a cocaine challenge after several weeks without cocaine treatment (Kalivas & Stewart, 1991). Extracellular DA levels in the striatum (Kalivas & Duffy, 1993) and nucleus accumbens (Kuczenski & Segal, 1990) have been found to decrease in response to a cocaine challenge administered after a 1-4 day period of abstinence, but increase when the period is extended to 11-15 days (Kalivas & Duffy, 1993). Reduction of DA transporter (DAT) density in the nucleus accumbens shell, prefrontal cortex, and dorsal striatum of rats after 10 days or more of withdrawal from repeated cocaine administration has been reported in several studies (for review, see Pierce & Kalivas, 1997).…”

Maternal high fat diet during the perinatal period alters mesocorticolimbic dopamine in the adult rat offspring: reduction in the behavioral responses to repeated amphetamine administration

“…Acute administration of psychostimulants such as AMP is known to increase extracellular DA content in several terminal fields containing DA and norepinephrine transporters (Kuczenski and Segal 1990;Sharp et al 1987). In particular, locomotor activation after acute AMP treatment correlates with the time course change and amount of DA released in the NAc core as demonstrated by microdialysis experiments (Sharp et al 1987;Corda et al 2006).…”

Behavioral sensitization and extracellular dopamine responses to amphetamine after various treatments

“…We have previously shown that a test dose of AMPH or COC, administered at relatively short intervals after repeated single daily injections of the same dose of the stimulant, results in behavioral sensitization in the absence of a correspondingly enhanced extracellular DA response (Kuczenski and Segal 1990;Segal and Kuczenski 1992a,b). The present results extend this observation to AMPH treatment regimens which some investigators have suggested may facilitate the appearance of an increased DA response.…”

“…During the past several years, most investigators, using in vivo microdialysis methodologies, have reported that behavioral sensitization to AMPH-like stimulants is accompanied by an increased DA response in DA projection areas, including caudate-putamen (CP) and nucleus accumbens (NAC) (see, for example, Akimoto et al 1989;Kalivas and Duffy 1990;Patrick et al 1991;Keller Jr et al 1992;Parsons and Justice Jr 1993;Wolf et al 1993;Vezina 1993; see also Paulson and Robinson 1995, for a review). However, while these observations suggest that enhanced DA may underlie sensitization, we (Kuczenski and Segal 1990;Segal and Kuczenski 1992a,b) and others (see, for example Narahashi 1974;Hurd and Ungerstedt 1989;Hurd et al 1990;Unterwald et al 1994;Wolf et al 1994;Heidbreder et al 1996;Imperato et al 1996) have noted that behavioral sensitization to both AMPH and cocaine (COC) can be obtained in the absence of an enhanced DA response in either CP or NAC. In fact, Kalivas and Duffy (1993) observed sensitization to the locomotor effects of COC in the presence of an increase, a decrease, and no change in the extracellular DA response.…”

Neurobehavioral alterations in HIV-1 transgenic rats: Evidence for dopaminergic dysfunction

“…Previous studies have demonstrated that behavioral sensitization may be observed in response to a cocaine challenge after several weeks without cocaine treatment (Kalivas & Stewart, 1991). Extracellular DA levels in the striatum (Kalivas & Duffy, 1993) and nucleus accumbens (Kuczenski & Segal, 1990) have been found to decrease in response to a cocaine challenge administered after a 1-4 day period of abstinence, but increase when the period is extended to 11-15 days (Kalivas & Duffy, 1993). Reduction of DA transporter (DAT) density in the nucleus accumbens shell, prefrontal cortex, and dorsal striatum of rats after 10 days or more of withdrawal from repeated cocaine administration has been reported in several studies (for review, see Pierce & Kalivas, 1997).…”

Maternal high fat diet during the perinatal period alters mesocorticolimbic dopamine in the adult rat offspring: reduction in the behavioral responses to repeated amphetamine administration

“…Acute administration of psychostimulants such as AMP is known to increase extracellular DA content in several terminal fields containing DA and norepinephrine transporters (Kuczenski and Segal 1990;Sharp et al 1987). In particular, locomotor activation after acute AMP treatment correlates with the time course change and amount of DA released in the NAc core as demonstrated by microdialysis experiments (Sharp et al 1987;Corda et al 2006).…”

Behavioral sensitization and extracellular dopamine responses to amphetamine after various treatments

“…We have previously shown that a test dose of AMPH or COC, administered at relatively short intervals after repeated single daily injections of the same dose of the stimulant, results in behavioral sensitization in the absence of a correspondingly enhanced extracellular DA response (Kuczenski and Segal 1990;Segal and Kuczenski 1992a,b). The present results extend this observation to AMPH treatment regimens which some investigators have suggested may facilitate the appearance of an increased DA response.…”

“…During the past several years, most investigators, using in vivo microdialysis methodologies, have reported that behavioral sensitization to AMPH-like stimulants is accompanied by an increased DA response in DA projection areas, including caudate-putamen (CP) and nucleus accumbens (NAC) (see, for example, Akimoto et al 1989;Kalivas and Duffy 1990;Patrick et al 1991;Keller Jr et al 1992;Parsons and Justice Jr 1993;Wolf et al 1993;Vezina 1993; see also Paulson and Robinson 1995, for a review). However, while these observations suggest that enhanced DA may underlie sensitization, we (Kuczenski and Segal 1990;Segal and Kuczenski 1992a,b) and others (see, for example Narahashi 1974;Hurd and Ungerstedt 1989;Hurd et al 1990;Unterwald et al 1994;Wolf et al 1994;Heidbreder et al 1996;Imperato et al 1996) have noted that behavioral sensitization to both AMPH and cocaine (COC) can be obtained in the absence of an enhanced DA response in either CP or NAC. In fact, Kalivas and Duffy (1993) observed sensitization to the locomotor effects of COC in the presence of an increase, a decrease, and no change in the extracellular DA response.…”

Neurobehavioral alterations in HIV-1 transgenic rats: Evidence for dopaminergic dysfunction

“…Previous studies have demonstrated that behavioral sensitization may be observed in response to a cocaine challenge after several weeks without cocaine treatment (Kalivas & Stewart, 1991). Extracellular DA levels in the striatum (Kalivas & Duffy, 1993) and nucleus accumbens (Kuczenski & Segal, 1990) have been found to decrease in response to a cocaine challenge administered after a 1-4 day period of abstinence, but increase when the period is extended to 11-15 days (Kalivas & Duffy, 1993). Reduction of DA transporter (DAT) density in the nucleus accumbens shell, prefrontal cortex, and dorsal striatum of rats after 10 days or more of withdrawal from repeated cocaine administration has been reported in several studies (for review, see Pierce & Kalivas, 1997).…”