In vivo Immunomodulatory Potential of Aqueous Extract of Different parts of Terminalia catappa L.

Abstract

Venkatalakshmi et al.: Immunomodulatory Potential of Terminalia catappa LModulation of immunity is the most sought therapeutic effect as many human ailments arise because of imbalance in immune mechanisms. In the current corona virus disease scenarios also, the role of immunity to combat the dreadful virus has been well emphasized. Hence the present study aims at evaluating the immunomodulatory potential of aqueous extract obtained from the different parts such as bark, fruit and wood of Terminalia catappa. Based on the results obtained in acute oral toxicity and dose fixation studies, medium dose (250 mg/kg body weight) of selected plant extracts were administered for 14 d to swiss albino mice to evaluate nonspecific (neutrophil adhesion, phagocytic index) and specific (hemagglutination antibody titer, delayed type hypersensitivity) immunomodulatory properties. The results obtained for plant extract treated groups were compared with cyclophosphamide (immunosuppressant) treated and levamisole (immunostimulant) treated mice. From the data of the results obtained it could be concluded that selected parts of Terminalia catappa have immune stimulatory as well as anti-inflammatory properties, thereby proving their efficacy as true immunomodulators. Among the parts selected, fruits exhibited significant immunomodulatory potential followed by bark and wood.

T. Catappa confers an antioxidant effect to electrospun polyvinyl alcohol nanofibers

“…The evaluation of the qualitative chemical profile of the T. catappa extract used in this study has shown, among others, the presence of flavonoids such as quercetin, rutin, isoorientin, vitexin and isovitexin, as well as the presence of hydrolysable tannins such as gallic acid and ellagic acid, and also triterpenoid derivatives such as asian and ursolic acid (BOSCARATO et al, 2021;TERÇAS et al, 2017;VENKATALAKSHMI, P.;BRINDHA,2021;MININEL et al, 2014). These flavonoid and non-flavonoid polyphenols, abundant compounds derived from plant secondary metabolism, are related to the ability of medicinal plants to neutralize free radicals (MOHAMMED et al,2022), being attributed to them anti-inflammatory and antioxidant activities of T. catappa (YADAV et al, 2021;IHEAGWAM et al, 2022).…”

Terminalia brownii Fresen: Stem Bark Dichloromethane Extract Alleviates Pyrogallol‐Induced Suppression of Innate Immune Responses in Swiss Albino Mice

“…Stimulating immune responses is desirable for patients with a compromised immune system, including patients with HIV and AIDs. Alternatively, immunosuppression alleviates aggressive pathological immune responses, including the rejection of transplanted organs, inflammatory diseases, and autoimmune disorders, among others [ 19 ]. Pyrogallol is a commercially available polyphenol [ 29 ].…”

“…Te most recent achievement in this feld is the approval of an immunomodulator, colchicine, an alkaloid isolated from Colchicum autumnale, by the Federal Drug Administration in 2009 for treating acute gout fares and Familial Mediterranean fever [16]. Several Terminalia species, including T. arjuna, T. bellirica, T. catappa, and T. chebula, modulate immune responses [17][18][19][20][21][22][23][24][25][26][27]. Te modulation of the immune system encompasses any adjustment of immune responses, including inhibition or stimulation of its function [28].…”

Understanding the Seasonal Effect of Metabolite Production in Terminalia catappa L. Leaves through a Concatenated MS- and NMR-Based Metabolomics Approach

“…Previous phytochemical studies conducted on the extracts of T. catappa leaves have shown that the species possesses mainly compounds of the phenolic classes [ 11 , 26 , 27 ], including flavonoids [ 26 , 27 , 28 ] and hydrolyzable tannins [ 11 , 27 ]. Diverse classes of metabolites found in T. catappa , which are known for their benefits to human health, may also play important ecological roles.…”