2010
DOI: 10.1111/j.1600-079x.2010.00769.x
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Abstract: The protective in vivo effects of melatonin or pinoline on carbon tetrachloride (CCl(4))-induced oxidative damage were investigated in liver of rats and compared to rats injected only with CCl(4) (5 mL/kg body weight). Hepatic cell membrane fluidity, monitored using fluorescence spectroscopy, exhibited a significant decrease in animals exposed to CCl(4) compared to control rats. Increases in lipid and protein oxidation, as assessed by concentrations of malondialdehyde (MDA) and 4-hydroxyalkenals (4-HDA), and p… Show more

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Cited by 17 publications
(12 citation statements)
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“…Assays as those for thiobarbituric‐ or thiobarbituric‐like reactive substances have been extensively used as indices of lipid peroxidation. Multiple recent studies have documented the utility and efficacy of melatonin in preventing elevation of MDA+4‐HDA concentrations caused by numerous diseases and by toxicological experimental models to generate in vivo and in vitro lipid peroxidation .…”
Section: Melatonin Protects Against Membrane Rigidity Due To Lipid Pementioning
confidence: 99%
“…Assays as those for thiobarbituric‐ or thiobarbituric‐like reactive substances have been extensively used as indices of lipid peroxidation. Multiple recent studies have documented the utility and efficacy of melatonin in preventing elevation of MDA+4‐HDA concentrations caused by numerous diseases and by toxicological experimental models to generate in vivo and in vitro lipid peroxidation .…”
Section: Melatonin Protects Against Membrane Rigidity Due To Lipid Pementioning
confidence: 99%
“…Melatonin also increased IGF-I expression at a dose of 25 mg/kg BW, and membrane rigidity and protein oxidation were fully prevented by melatonin at 10 mg/kg BW [16]. Morphological and histopathological changes induced by CCl 4 were restored after melatonin (10 or 25 mg/kg BW) treatment in rats [14,20]. The chronic liver injury induced by CCl 4 was less studied than acute injury.…”
Section: Protective Effects Of Melatonin On Liver Injuriesmentioning
confidence: 99%
“…The most reactive and, therefore, destructive of the ROS is the hydroxyl radical ( OH). Melatonin has repeatedly been shown, using a wide variety of techniques, to rapidly scavenge this reactant when and where it is intracellularly generated; this deprives the OH of the opportunity to destroy critical neighboring molecules [17][18][19][20][21][22]. Melatonin, however, does not restrict itself to scavenging only the OH; rather, it also interacts with and neutralizes with varying degrees of efficiency, singlet oxygen, the superoxide anion radical, hydrogen peroxide and the peroxynitrite anion [23][24][25][26][27].…”
Section: Melatonin: Neutralizing Free Radicalsmentioning
confidence: 97%
“…Thus in addition to DNA, lipids and proteins are also highly vulnerable and are oxidized if free radicals are uncontested; these lesions lead to molecular damage and reduced cellular function. As with DNA, melatonin also protects lipids and proteins from damage by radical products produced as a consequence of ionizing radiation or other processes [18,21,[65][66][67][68][69]. Finally, whereas melatonin is a highly effective protector against free radical damage, the derivatives of melatonin, which as noted above, function as scavengers and likewise efficiently defer molecular damage [28,30,31,70,71].…”
Section: Melatonin: Protecting Macromoleculesmentioning
confidence: 98%