volume 281, issue 6, P1659-1678 2014
DOI: 10.1111/febs.12731
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Abstract: In vivo-folded metal-metallothionein 3 complexes reveal the Cu-thionein rather than Zn-thionein character of this brain-specific mammalian metallothionein -Cu + replacement processes, is presented here. We conclude that MT3 has a Cu-thionein character that is stronger than that of the MT1 and MT2 isoforms -also present in the mammalian brain -which is mainly contributed by its b domain. In contrast, the a domain retains a high capacity to bind Zn 2+ ions, and, consequently, the entire MT3 peptide shows a pecu…

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