In vivo effects of Buthus occitanus tunetanus and Androctonus australis garzoni scorpion venoms on pregnant and non-pregnant rats

Hmed, B. N.; Serria, Hammami Turky; Selma, C.; Sahnoun, Zouheir; Rebaï, Tarek; Mondher, K.; Zakaria, Bengaly; Mounir, Zeghal Khaled

doi:10.1590/s1678-91992008000200013

Cited by 2 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the day of the experiment, crude scorpion venom was appropriately diluted with a 0.9% saline physiologic solution in order to obtain a protein concentration of 300 µg/kg. This venom dose is about 1/5 of the LD50 of Bot in pregnant rats (12).…”

Section: Scorpion Venommentioning

confidence: 99%

Embryotoxicity following repetitive maternal exposure to scorpion venom

Hmed¹,

Badraoui²,

Serria³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

View full text Add to dashboard Cite

Abstract:Although it is a frequent accident in a few countries, scorpion envenomation during pregnancy remains scarcely studied. In the present study, the effects of repetitive maternal exposure to Buthus occitanus tunetanus venom are investigated and its possible embryotoxic consequences on rats. Primigravid rats received a daily intraperitoneal dose of 1 mL/kg of saline solution or 300 µg/kg of crude scorpion venom, from the 7 th to the 13 th day of gestation. On the 21 st day, the animals were deeply anesthetized using diethylether. Then, blood was collected for chemical parameter analysis. Following euthanasia, morphometric measurements were carried out. The results showed a significant increase in maternal heart and lung absolute weights following venom treatment. However, the mean placental weight per rat was significantly diminished. Furthermore, blood urea concentration was higher in exposed rats (6.97 ± 0.62 mmol/L) than in those receiving saline solution (4.94 ± 0.90 mmol/L). Many organs of venom-treated rat fetuses (brain, liver, kidney and spleen) were smaller than those of controls. On the contrary, fetal lungs were significantly heavier in fetuses exposed to venom (3.2 ± 0.4 g) than in the others (3.0 ± 0.2 g). Subcutaneous blood clots, microphthalmia and total body and tail shortening were also observed in venom-treated fetuses. It is concluded that scorpion envenomation during pregnancy potentially causes intrauterine fetal alterations and growth impairment.

show abstract

Section: Scorpion Venommentioning

confidence: 99%