In vivo dual-targeted chemotherapy of drug resistant cancer by rationally designed nanocarrier

Wang, Yang; Zhao, Ruibo; Wang, Shibing; Liu, Zhaoming; Tang, Ruikang

doi:10.1016/j.biomaterials.2015.09.030

Cited by 63 publications

(37 citation statements)

References 41 publications

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“…Yolk–shell Fe 3 O 4 @MgSiO 3 magnetic mesoporous nanocomposite was developed, in which the hollow cavity was used to load DOX, and FA and iron oxide core provided the molecule targeting and magnetic‐guided drug delivery. The drug‐loaded Fe 3 O 4 @MgSiO 3 presented excellent efficacy to kill the multidrug resistant Hep‐G2/MDR tumor cells …”

Section: Positive Targetingmentioning

confidence: 99%

Recent Advances in Targeted Tumor Chemotherapy Based on Smart Nanomedicines

Qin

Zhang

2018

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Efficacy and safety of chemotherapeutic drugs constitute two major criteria in tumor chemotherapy. Nanomedicines with tumor-targeted properties hold great promise for improving the efficacy and safety. To design targeted nanomedicines, the pathological characteristics of tumors are extensively and deeply excavated. Here, the rationale, principles, and advantages of exploiting these pathological characteristics to develop targeted nanoplatforms for tumor chemotherapy are discussed. Homotypic targeting with the ability of self-recognition to source tumors is reviewed individually. In the meanwhile, the limitations and perspective of these targeted nanomedicines are also discussed.

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Section: Positive Targetingmentioning

confidence: 99%

Recent Advances in Targeted Tumor Chemotherapy Based on Smart Nanomedicines

Qin

Zhang

2018

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“…As shown in Figure 1, these well-designed NPs could efficiently accumulate into the tumor site and metastatic lymph nodes via the enhanced permeability and retention (EPR) effect. [38][39][40] Under NIR irritation, the PS P@ can produce optical fluorescence, which is used for the early diagnosis and tracking drug delivery. In addition, the released Gem as well as P@ will contribute a combined PDT and chemotherapy effect.…”

Section: Introductionmentioning

confidence: 99%

Triple-functional albumin-based nanoparticles for combined chemotherapy and photodynamic therapy of pancreatic cancer with lymphatic metastases

Yu¹,

Zhu²,

Yang³

et al. 2017

IJN

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Lymphatic metastasis is the major metastatic pattern of pancreatic cancer and considered as an independent risk factor of survival. However, there is still no effective way for the diagnosis and treatment for lymphatic metastases of pancreatic cancer. In this study, using albumin as a carrier of gemcitabine (Gem), further modified by pyropheophorbide-a, we have designed and synthesized a nanoparticle (NP) compound named “pheophorbide-a (P@)-Gem-human serum albumin (HSA)-NPs”. By utilization of its tracer ability of lymphatic metastases, which is triggered by near-infrared irradiation and its visible dying ability, the compound is used for drug delivery tracking, meanwhile as a treating drug, as well as the combined effect of photodynamic therapy and chemotherapy. By the nude mice model of lymphatic metastases of pancreatic cancer (BxPC-3-LN7), we aim to explore the feasibility, effectiveness, and biological safety of diagnosis and treatment for the lymphatic metastases of pancreatic cancer by P@-Gem-HSA-NP, thereby, providing new methods and strategies for the study of nanodrug carrier and research on lymphatic metastases of pancreatic cancer.

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“…Many advantages of polymeric micelles for cancer therapy have been reported, including reduced toxicity, remarkable biocompatibility, controllable drug release and prolonged circulation time . In addition, polymeric micelles tend to accumulate in tumor tissues owing to the enhanced permeability and retention (EPR) effect . Nevertheless, the passive targeted efficiency of the EPR effect is insufficient to achieve a high enough concentration of drug in malignant tumor tissues.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Mixed Micelles for Efficient Docetaxol Delivery for Cancer Therapy

Zhang

et al. 2016

ChemPlusChem

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The objective of this study was to build mixed micelles based on two functional co‐polymers, including the redox‐sensitive polymer–drug conjugate methoxy poly(ethylene glycol)–poly(γ‐benzyl l‐glutamate)‐disulfide‐docetaxel (PEG–PBLG‐SS‐DTX) and the actively targeting methoxy poly(ethylene glycol)–folic acid (PEG–FA), for enhanced target specificity and improved anticancer efficiency of docetaxel (DTX). The spherical PEG–PBLG‐SS‐DTX/PEG–FA mixed micelles prepared by the dialysis method revealed a narrowly distributed size at 129.7±2.1 nm with low polydispersity of 0.10±0.02. Furthermore, the critical micelle concentration of the mixed micelles was 5.08 μg mL−1, indicating excellent self‐assembly ability in water and stability against dilution in blood circulation. The in vitro release study revealed that the conjugated DTX was rapidly released in response to dl‐dithiothreitol (DTT), a reducing agent. Only 12.3 % of DTX was released from the mixed micelles after 120 h in the absence of DTT. However, the accumulative release of DTX dramatically accelerated and reached more than 40 % in 120 h after addition of DTT. The in vitro cytotoxicity, cellular uptake and cell apoptosis experiments on the mixed micelles were performed using MTT assay, fluorescence inverted microscopy and flow cytometric analysis, and 4′,6‐diamidino‐2‐phenylindole (DAPI) staining, respectively, on folate receptor (FR)‐negative A549 and FR‐positive MCF‐7 cells. The mixed micelles could be taken up efficiently by MCF‐7 cells by FR‐mediated endocytosis compared with PEG–PBLG‐SS‐DTX micelles. Furthermore, remarkable cytotoxicity and cell apoptosis were identified for the mixed micelles against MCF‐7 cells, which was consistent with the results of the cellular uptake study. On the basis of these results, the redox‐sensitive PEG–PBLG‐SS‐DTX/PEG–FA mixed micelles using FA as a targeting ligand revealed prominent antitumor efficiency and might be a latent drug carrier for cancer chemotherapy.

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In vivo dual-targeted chemotherapy of drug resistant cancer by rationally designed nanocarrier

Cited by 63 publications

References 41 publications

Recent Advances in Targeted Tumor Chemotherapy Based on Smart Nanomedicines

Recent Advances in Targeted Tumor Chemotherapy Based on Smart Nanomedicines

Triple-functional albumin-based nanoparticles for combined chemotherapy and photodynamic therapy of pancreatic cancer with lymphatic metastases

Multifunctional Mixed Micelles for Efficient Docetaxol Delivery for Cancer Therapy

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