2008
DOI: 10.1016/j.biomaterials.2008.05.002
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Abstract: Three-dimensional porous scaffolds prepared from regenerated silk fibroin using either an all aqueous process or a process involving an organic solvent, hexafluoroisopropanol (HFIP) have shown promise in cell culture and tissue engineering applications. However, their biocompatibility and in vivo degradation has not been fully established. The present study was conducted to systematically investigate how processing method (aqueous vs. organic solvent) and processing variables (silk fibroin concentration and po… Show more

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Cited by 681 publications
(574 citation statements)
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“…This process is in part caused by extracellular matrix product accumulation in and around regenerating tissue creating an inhospitable growth environment. The host immune system has a significant impact on the degradation of 3D SF porous scaffolds, and the degradation of silk sponges has been shown to be mediated by macrophages [24]. Similarly, it was observed in this study that macrophages clustered around SF fragments and had intracellular SF debris at 4 weeks, suggesting that silk is not only biodegradable but also bioresorbable.…”
Section: Discussionsupporting
confidence: 79%
“…This process is in part caused by extracellular matrix product accumulation in and around regenerating tissue creating an inhospitable growth environment. The host immune system has a significant impact on the degradation of 3D SF porous scaffolds, and the degradation of silk sponges has been shown to be mediated by macrophages [24]. Similarly, it was observed in this study that macrophages clustered around SF fragments and had intracellular SF debris at 4 weeks, suggesting that silk is not only biodegradable but also bioresorbable.…”
Section: Discussionsupporting
confidence: 79%
“…Nearly all silk processing is done in water without any harsh chemicals making it possible to dope silk devices with cells [14], growth factors [15], and laser dyes [16]. By using a material able to degrade within the body after a period of time, as is possible with silk [17], the need for a second surgery to retrieve the implanted waveguide is eliminated.…”
Section: Introductionmentioning
confidence: 99%
“…Silk proves to be a particularly favorable material for these needs because it provides a convenient connection of material form and biological function. The ability to control the material degradation properties (32) and reform silk biopolymers into technological formats adds opportunity for devices that can seamlessly operate at the nexus of enhanced imaging (through optical transduction), therapy (through drug stabilization and delivery), and quantitative feedback of therapy (through drug-delivery imaging within the same device). The results bear particular promise given the implications of individualized monitoring of drug delivery in vivo and the concepts for multifunctional devices, where a single device can administer a cure while providing information of disease progression.…”
mentioning
confidence: 99%