In vivo degradation of magnesium plate/screw osteosynthesis implant systems: Soft and hard tissue response in a calvarial model in miniature pigs

Schaller, Benoît; Saulačić, Nikola; Imwinkelried, T.; Beck, Stefan; Liu, Edwin Wei Yang; Gralla, Jan; Nakahara, Ken; Hofstetter, Willy; Iizuka, Tetsuya

doi:10.1016/j.jcms.2015.12.009

Cited by 62 publications

(43 citation statements)

References 34 publications

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“…The new bone volume fraction with the ARRm-H380 membrane approached almost 100% after 12 weeks implantation. Previous reports have verified that Mg ions act as a stimulator to enhance cell proliferation and migration, and that the functional biochemical stimulation of Mg ions can improve wound healing in vitro and in vivo [7,30]. To the best of our knowledge, this report is the first to discover that Mg-based materials are capable of being applied in dentistry with excellent outcomes.…”

Section: In Vivo Degradation and Bone Healing Situationsupporting

confidence: 51%

Development of a Novel Degradation-Controlled Magnesium-Based Regeneration Membrane for Future Guided Bone Regeneration (GBR) Therapy

Lin

Hung

Lee

et al. 2017

Metals

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Abstract:This study aimed to develop and evaluate the ECO-friendly Mg-5Zn-0.5Zr (ECO505) alloy for application in dental-guided bone regeneration (GBR). The microstructure and surface properties of biomedical Mg materials greatly influence anti-corrosion performance and biocompatibility. Accordingly, for the purpose of microstructure and surface modification, heat treatments and surface coatings were chosen to provide varied functional characteristics. We developed and integrated both an optimized solution heat-treatment condition and surface fluoride coating technique to fabricate a Mg-based regeneration membrane. The heat-treated Mg regeneration membrane (ARRm-H380) and duplex-treated regeneration membrane group (ARRm-H380-F24 h) were thoroughly investigated to characterize the mechanical properties, as well as the in vitro corrosion and in vivo degradation behaviors. Significant enhancement in ductility and corrosion resistance for the ARRm-H380 was obtained through the optimized solid-solution heat treatment; meanwhile, the corrosion resistance of ARRm-H380-F24 h showed further improvement, resulting in superior substrate integrity. In addition, the ARRm-H380 provided the proper amount of Mg-ion concentration to accelerate bone growth in the early stage (more than 80% new bone formation). From a specific biomedical application point of view, these research results point out a successful manufacturing route and suggest that the heat treatment and duplex treatment could be employed to offer custom functional regeneration membranes for different clinical patients.

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Section: In Vivo Degradation and Bone Healing Situationsupporting

confidence: 51%

Development of a Novel Degradation-Controlled Magnesium-Based Regeneration Membrane for Future Guided Bone Regeneration (GBR) Therapy

Lin

Hung

Lee

et al. 2017

Metals

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“…No pathologic changes were detected in the bone tissue around the implants, which indicated the absence of local toxicity. Different amounts of macrophages and multinucleated giant cells were observed around the implants (Fig 11e), and these cells have been previously shown to act as scavenger cells that eliminate the products of corrosion [77,78]. The in vivo osteoinductivity of the dopamine/gelatin/rhBMP-2-coated 5%β-TCP/ Mg-3%Zn composite may be attributed to the following factors: 1) the osteoinductivity of rhBMP-2 is strong in the early stage; 2) Mg 2+ can promote the differentiation of BMSCs into osteoblasts [28] and promote the proliferation and migration of osteoblasts [79]; 3) phosphorus ions, calcium ions, and gelatin facilitate mineralization in new bone tissue; and 4) the three-dimensional porous structure is beneficial to the process of bone tissue infiltration.…”

Section: Discussionmentioning

confidence: 86%

Enhanced osteoinductivity and corrosion resistance of dopamine/gelatin/rhBMP-2–coated β-TCP/Mg-Zn orthopedic implants: An in vitro and in vivo study

et al. 2020

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Magnesium-based biomaterials are attracting increasingly more attention for orthopedic applications based on their appropriate mechanical properties, biodegradability, and favorable biocompatibility. However, the high corrosion rate of these materials remains to be addressed. In this study, porous β-Ca 3 (PO 4) 2 /Mg-Zn (β-TCP/Mg-Zn) composites were fabricated via a powder metallurgy method. The β-TCP/Mg-Zn composites with 6% porosity exhibited optimal mechanical properties, and thus, they were selected for surface modification. A novel dopamine/gelatin/recombinant human bone morphogenetic protein-2 (rhBMP-2) coating with demonstrated stability was prepared to further improve the corrosion resistance of the composite and enhance early osteoinductivity. The homogeneously coated β-TCP/Mg-Zn composite showed significantly improved corrosion resistance according to electrochemical and immersion tests. In addition, extracts from the dopamine/ gelatin/rhBMP-2-coated β-TCP/Mg-Zn composite not only facilitated cell proliferation but also significantly enhanced the osteogenic differentiation of Sprague-Dawley rat bone marrow-derived mesenchymal stem cells in vitro. Furthermore, in vivo experiments were performed to evaluate the biodegradation, histocompatibility, and osteoinductive potential of the coated composite. No obvious pathological changes in the vital visceral organs were observed after implantation, and radiography and hematoxylin-eosin staining showed strong promotion of new bone formation, matched composite degradation and bone regeneration rates, and complete absorption of the released hydrogen gas. Collectively, these results indicate that the dopamine/gelatin/rhBMP-2-coated β-TCP/Mg-Zn composite offers improved corrosion resistance, favorable biocompatibility, and enhanced osteoinductive potential for use in the fabrication of orthopedic implants.

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“…The recent research in the field of Mg and its alloys revolves around two main applications: vascular stents and orthopedics . The first successful implantation of a biodegradable Mg stent became possible in 2005 when it was implanted in treating a left pulmonary artery of a 6 week old baby .…”

Section: Current Biomedical Applications Of Mgmentioning

confidence: 99%

“…Apart from cardiovascular applications, Mg has been investigated in the orthopedics applications in the form of pins, screws, rods, and plates . Biodegradation of Mg along with its good mechanical strength makes Mg one of the ideal materials for the orthopedic applications.…”

Section: Current Biomedical Applications Of Mgmentioning

confidence: 99%

The current trends of Mg alloys in biomedical applications—A review

2018

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Magnesium (Mg) has emerged as an ideal alternative to the permanent implant materials owing to its enhanced properties such as biodegradation, better mechanical strengths than polymeric biodegradable materials and biocompatibility. It has been under investigation as an implant material both in cardiovascular and orthopedic applications. The use of Mg as an implant material reduces the risk of long-term incompatible interaction of implant with tissues and eliminates the second surgical procedure to remove the implant, thus minimizes the complications. The hurdle in the extensive use of Mg implants is its fast degradation rate, which consequently reduces the mechanical strength to support the implant site. Alloy development, surface treatment, and design modification of implants are the routes that can lead to the improved corrosion resistance of Mg implants and extensive research is going on in all three directions. In this review, the recent trends in the alloying and surface treatment of Mg have been discussed in detail. Additionally, the recent progress in the use of computational models to analyze Mg bioimplants has been given special consideration.

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In vivo degradation of magnesium plate/screw osteosynthesis implant systems: Soft and hard tissue response in a calvarial model in miniature pigs

Cited by 62 publications

References 34 publications

Development of a Novel Degradation-Controlled Magnesium-Based Regeneration Membrane for Future Guided Bone Regeneration (GBR) Therapy

Development of a Novel Degradation-Controlled Magnesium-Based Regeneration Membrane for Future Guided Bone Regeneration (GBR) Therapy

Enhanced osteoinductivity and corrosion resistance of dopamine/gelatin/rhBMP-2–coated β-TCP/Mg-Zn orthopedic implants: An in vitro and in vivo study

The current trends of Mg alloys in biomedical applications—A review

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