volume 191, issue 12, P6060-6070 2013
DOI: 10.4049/jimmunol.1302044
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Praveen K. Amancha, Jung Joo Hong, Kenneth Rogers, Aftab A. Ansari, Francois Villinger

Abstract: The PD-1/PD-Ligand pathway has been shown to limit cell mediated effector functions during chronic viral infections impeding clearance of pathogens. As a strategy to reverse this exhaustion and increase T cell poly-functionality, PD-1 ligands were blocked in vivo using a recombinant macaque PD1-Fc fusion protein (rPD-1-Fc) in SIVmac239 infected rhesus macaques during the early chronic phase of infection, either alone or in combination with ART. In vitro blockade showed improvement of antigen specific CD4+ and…

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