2018
DOI: 10.1055/s-0038-1675595 View full text |Buy / Rent full text
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Abstract: Background Expanded polytetrafluoroethylene (ePTFE) is a suture material for annuloplasty in aortic valve repair. For this particular application, it should induce minimal local stress and promote rapid tissue incorporation. To achieve this, a novel ePTFE suture with a larger diameter and high porosity in its midsection has been developed. Herein, we analyzed the acute and chronic tissue reaction to this suture material compared with a commercially available control ePTFE suture. Methods Novel and … Show more

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“…As a dual benefit, the knot is less of a breaking point and the risk of gapping is minimized [ 26 ]. In addition, PTFE is biologically inert [ 27 ] and less likely to cause inflammation [ 5 , 28 ]. Finally, as a monofilamentous material, it is less prone to infection [ 29 ].…”
Section: Discussionmentioning
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“…As a dual benefit, the knot is less of a breaking point and the risk of gapping is minimized [ 26 ]. In addition, PTFE is biologically inert [ 27 ] and less likely to cause inflammation [ 5 , 28 ]. Finally, as a monofilamentous material, it is less prone to infection [ 29 ].…”
Section: Discussionmentioning
“…Related substances like Gore-Tex® (expanded polytetrafluoroethylene) or Teflon are widely used in cardiovascular and plastic surgery. There is little foreign body reaction in animal models using the material which stands for an adequate biocompatibility [6][7][8].…”
Section: Introductionmentioning
“…These hydrophobic surfaces are known to have considerable affinity for oil droplets in aqueous environments, that is, they adsorb proteins and lipids, and do not inhibit blood clotting reactions. 89–93 Essentially, research on material design from the physicochemical viewpoint of controlling surface free energy and interfacial energy, involving aspects such as simple hydrophilicity and hydrophobicity, has not succeeded in yielding anti-blood-coagulating properties.…”
Section: Construction Of Biointerfacesmentioning
“…The biocompatibility of sutures has also been evaluated via IVM in mouse WC models. [407] Finally, transparent graphene electrodes have recently been developed to enable the simultaneous recording of electrophysiology and in vivo imaging for studies of brain and neuronal physiology. [408,409] In these studies, the electrode is implanted directly in the cranial WC to apply electrical stimulation or record electrical signals, while fluorescence IVM is used to record changes in signaling, such as with the GCaMP6f calcium signaling reporter mouse model.…”
Section: Foreign Body Responsesmentioning