In vivo biocompatibility and biodegradability of poly(lactic acid)/poly(ε-caprolactone) blend compatibilized with poly(ε-caprolactone-b-tetrahydrofuran) in Wistar rats

Conde, Gabriel; Carvalho, Júlia Ribeiro Garcia de; Dias, Paula do Patrocínio; Moranza, Henriette Gellert; Montanhim, Gabriel Luiz; Ribeiro, Juliana; Chinelatto, Marcelo Aparecido; Moraes, Paola Castro; Taboga, Sebastião Roberto; Bertolo, Paulo Henrique Leal; Funnicelli, Michelli Inácio Gonçalves; Pinheiro, Daniel Guariz; Ferraz, Guilherme de Camargo

doi:10.1088/2057-1976/abeb5a

Cited by 11 publications

(9 citation statements)

References 45 publications

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“…In addition, a significant neutrophil population increase was observed in the peritoneal space following microcapsules implantation 167 . Conversely, PLA and PLA/PCL blend implants elicited similar FBR following subcutaneous and intraperitoneal implantation in rats for 2, 8, and 24 weeks 168 . In another study, cylindrical PEG hydrogels were implanted in the subcutaneous space, abdominal cavity, and adipose tissue 115 .…”

Section: Implant Properties Affect the Degree Of Host Responsementioning

confidence: 97%

“… 167 Conversely, PLA and PLA/PCL blend implants elicited similar FBR following subcutaneous and intraperitoneal implantation in rats for 2, 8, and 24 weeks. 168 In another study, cylindrical PEG hydrogels were implanted in the subcutaneous space, abdominal cavity, and adipose tissue. 115 The mildest inflammatory response was induced by subcutaneous implants, followed by implants in the abdominal cavity.…”

Section: Implant Properties Affect the Degree Of Host Responsementioning

confidence: 99%

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Advanced strategies to thwart foreign body response to implantable devices

Capuani

Malgir

Chua

et al. 2022

Bioengineering & Transla Med

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Mitigating the foreign body response (FBR) to implantable medical devices (IMDs) is critical for successful long‐term clinical deployment. The FBR is an inevitable immunological reaction to IMDs, resulting in inflammation and subsequent fibrotic encapsulation. Excessive fibrosis may impair IMDs function, eventually necessitating retrieval or replacement for continued therapy. Therefore, understanding the implant design parameters and their degree of influence on FBR is pivotal to effective and long lasting IMDs. This review gives an overview of FBR as well as anti‐FBR strategies. Furthermore, we highlight recent advances in biomimetic approaches to resist FBR, focusing on their characteristics and potential biomedical applications.

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Section: Implant Properties Affect the Degree Of Host Responsementioning

confidence: 97%

Section: Implant Properties Affect the Degree Of Host Responsementioning

confidence: 99%

Advanced strategies to thwart foreign body response to implantable devices

Capuani

Malgir

Chua

et al. 2022

Bioengineering & Transla Med

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show abstract

“…In addition, PLA has good biological safety, mechanical resistance, and processability profiles [ 6 , 7 ]. In the biomedical area, PLA has been used as a degradable suture, bone fixation device, material for surgical implants, drug delivery systems, and scaffolds for human and rodent tissue engineering applications [ 1 , 6 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Long-Term Evaluation of Poly(lactic acid) (PLA) Implants in a Horse: An Experimental Pilot Study

et al. 2021

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In horses, there is an increasing interest in developing long-lasting drug formulations, with biopolymers as viable carrier alternatives in addition to their use as scaffolds, suture threads, screws, pins, and plates for orthopedic surgeries. This communication focuses on the prolonged biocompatibility and biodegradation of PLA, prepared by hot pressing at 180 °C. Six samples were implanted subcutaneously on the lateral surface of the neck of one horse. The polymers remained implanted for 24 to 57 weeks. Physical examination, plasma fibrinogen, and the mechanical nociceptive threshold (MNT) were performed. After 24, 28, 34, 38, and 57 weeks, the materials were removed for histochemical analysis using hematoxylin-eosin and scanning electron microscopy (SEM). There were no essential clinical changes. MNT decreased after the implantation procedure, returning to normal after 48 h. A foreign body response was observed by histopathologic evaluation up to 38 weeks. At 57 weeks, no polymer or fibrotic capsules were identified. SEM showed surface roughness suggesting a biodegradation process, with an increase in the median pore diameter. As in the histopathological evaluation, it was not possible to detect the polymer 57 weeks after implantation. PLA showed biocompatible degradation and these findings may contribute to future research in the biomedical area.

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“…Even though there are other polymers like PGA, PLA, PU, etc. that can be electrospun, we decided to choose PCL for this application because of its proven biocompatibility and attractive mechanical properties (Conde et al., 2021). The present study concentrates on the fabrication of a highly porous and fluffy 3D scaffold of PCL by wet electrospinning and conjugation of collagen I, an ECM molecule on the surface for effective infiltration, attachment, and differentiation of rat ADMSCs into ILCs with specific cluster size.…”

Section: Introductionmentioning

confidence: 99%

Three‐dimensional wet electrospun scaffold system for the differentiation of adipose‐derived mesenchymal stem cells to islet‐like clusters

Wilson

V.G.

Thomas

et al. 2022

J Tissue Eng Regen Med

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Stem cell‐derived islet‐like clusters (ILCs) are an alternative source of pancreatic beta cells for the treatment of diabetic mellitus. An ideal 3D culture platform for the generation of ILCs of desired cluster size is a challenge due to the clustering of islet cells in the 2D culture systems. The islet cells cultured in 2D conditions produce clusters of large size, which are less efficient in terms of insulin secretion and viability. In this study, we report that ILCs formed on a PCL‐based wet electrospun fibrous scaffold with larger pore size produced clusters of the desired size, compared to that cultured on a conventional electrospun sheet. The collagen functionalization on this wet electrospun polycaprolactone (PCL) scaffold showed enhanced insulin secretion and cell viability compared to the non‐functionalized or conventionally electrospun PCL scaffold. The collagen‐coated wet electrospun 3D scaffold produced ILCs of cluster diameter 70 ± 20 μm and the conventionally electrospun PCL sheet produced larger ILC clusters of diameter 300 ± 10 μm. Hence the results indicate the collagen‐functionalized wet electrospun scaffold system could be a potential scaffold for islet tissue engineering.

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In vivo biocompatibility and biodegradability of poly(lactic acid)/poly(ε-caprolactone) blend compatibilized with poly(ε-caprolactone-b-tetrahydrofuran) in Wistar rats

Cited by 11 publications

References 45 publications

Advanced strategies to thwart foreign body response to implantable devices

Advanced strategies to thwart foreign body response to implantable devices

Long-Term Evaluation of Poly(lactic acid) (PLA) Implants in a Horse: An Experimental Pilot Study

Three‐dimensional wet electrospun scaffold system for the differentiation of adipose‐derived mesenchymal stem cells to islet‐like clusters

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