In vivo assessment of possible probiotic properties of Zymomonas mobilis in a Wistar rat model

Azerêdo, Geíza Alves; Stamford, Tânia Lúcia Montenegro; Souza, Evandro Leite de; Veras, Flávio Fonseca; Almeida, Érika Rodrigues de; Araújo, Janete Magalí de

doi:10.2225/vol13-issue2-fulltext-4

Cited by 10 publications

(7 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Zymomonas species have also been shown to produce levan, a polysaccharide used as a thickening agent, which has been demonstrated to have antitumor effects (Calazans et al ., ; Yoon et al ., ), immunostimulating activity (Xu et al ., ), effects on lipid metabolism (Yamamoto et al ., ) and prebiotic activity (Dal Bello et al ., ; Jang et al ., ). Zymomonas itself has been shown to be safe for consumption (de Azeredo et al ., ) and to have beneficial immunomodulatory effects by protecting against sepsis in mice (Campos et al ., ). Further analysis is required to characterise the strains of Zymomonas present in these beverages and their contribution, through the production of leaven, sorbitol and ethanol, on the consistency, flavour and safety of the final beverage.…”

Section: Resultsmentioning

confidence: 99%

Sequence-based analysis of the microbial composition of water kefir from multiple sources

Marsh

O'Sullivan

Hill

et al. 2013

FEMS Microbiol Lett

View full text Add to dashboard Cite

Water kefir is a water-sucrose-based beverage, fermented by a symbiosis of bacteria and yeast to produce a final product that is lightly carbonated, acidic and that has a low alcohol percentage. The microorganisms present in water kefir are introduced via water kefir grains, which consist of a polysaccharide matrix in which the microorganisms are embedded. We aimed to provide a comprehensive sequencing-based analysis of the bacterial population of water kefir beverages and grains, while providing an initial insight into the corresponding fungal population. To facilitate this objective, four water kefirs were sourced from the UK, Canada and the United States. Culture-independent, high-throughput, sequencing-based analyses revealed that the bacterial fraction of each water kefir and grain was dominated by Zymomonas, an ethanol-producing bacterium, which has not previously been detected at such a scale. The other genera detected were representatives of the lactic acid bacteria and acetic acid bacteria. Our analysis of the fungal component established that it was comprised of the genera Dekkera, Hanseniaspora, Saccharomyces, Zygosaccharomyces, Torulaspora and Lachancea. This information will assist in the ultimate identification of the microorganisms responsible for the potentially health-promoting attributes of these beverages.

show abstract

Section: Resultsmentioning

confidence: 99%

Sequence-based analysis of the microbial composition of water kefir from multiple sources

Marsh

O'Sullivan

Hill

et al. 2013

FEMS Microbiol Lett

View full text Add to dashboard Cite

show abstract

“…Nos últimos anos, a incorporação de bactérias probióticas em alimentos tem recebido crescente interesse científi co para a promoção da saúde e prevenção de doenças, atrelado a esse fato, estudos acerca da segurança do uso desses compostos funcionais também têm despertado destaque (23). Nesse contexto, Z. mobilis (UFPEDA 355) não foi capaz de penetrar na corrente sanguínea e não provocou alterações morfológicas nos rins, fígado e intestinos de camundongos que receberam inoculação via gavagem de uma cultura (109 UFC/ mL) três vezes ao dia, evidenciando assim que não é uma bactéria patogênica para o modelo e condições empregadas (21).…”

Section: Seleçãounclassified

“…Além disso, ao longo do experimento, os ratos se apresentaram saudáveis, curiosos e ativos. Nenhuma doença ou morte ocorreu e não havia sinais de distúrbios gastrintestinais, incluindo diarreia ou vômito (23).…”

Section: Seleçãounclassified

Aplicabilidades Terapêuticas De Zymomonas Mobilis Sobre Fatores Predisponentes Das Dislipidemias E Do Câncer Colorretal: Uma Revisão De Literatura

Muniz¹,

Muniz²,

Silva³

et al. 2022

Infarma

View full text Add to dashboard Cite

Zymomonas mobilis é uma bactéria Gram-negativa, móvel, anaeróbia facultativa e não patogênica que quando fermentada a partir da sacarose, é capaz de produzir metabólitos com atividades biologicamente ativas. O presente estudo tem como objetivo identifi ca,r por meio de uma revisão de literatura, as aplicabilidades terapêuticas de Z. mobilis sobre fatores predisponentes das dislipidemias e do câncer de colorretal. Oligômeros de frutose, levana e frutooligossacarídeos (FOS) são compostos bioativos resultantes da fermentação da sacarose por Z. mobilis e vêm despertando interesse por suas potenciais aplicações terapêuticas. A levana possui ação imunomoduladora e antitumoral em células hepáticas e intestinais, enquanto os FOS agem no metabolismo lipídico, regulando os níveis do colesterol sérico e da lipoproteína de baixa densidade (LDL), assim suprimindo a esteatose hepática. Esse probiótico pode desencadear também um efeito protetor no cólon por sua capacidade de inibir bactérias patogênicas, como Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus e Salmonella spp., que são capazes de provocar disbiose e alteração do trânsito intestinal. A Z. mobilis, por atuar no controle da desregulação do metabolismo lipídico e na manutenção da homeostase da microbiota intestinal, pode ser adotada como uma alternativa simbiótica diante dos fatores predisponentes de enfermidades crônicas, como dislipidemias e neoplasias do colorretal.

show abstract

“…Group 2: Supplemented with probioticated Moringa oleifera leaf extract (10 7 CFU/ 0.3 ml with 300 mg Moringa oleifera leaf extract/kg body weight). Group 3: Supplemented with Lactic acid bacteria (10 7 CFU/ 0.3 ml / kg body weight) and Group 4: Supplemented with commercially available iron supplements of 1ml/rat 12 . The dose was administrated to all the rats via gavage and amount of dose given to each rats was calculated individually based on body weight.…”

Section: Grouping Of Experimental Ratsmentioning

confidence: 99%

Influence of Probioticated Moringa Oleifera Leaf Extract for Treatment of Anaemia Using Animal Model

Staroń¹,

Aravindh²,

Ramya³

2017

Int. Res. J. Pharm.

View full text Add to dashboard Cite

An attempt was made to evaluate anti-anaemic properties of probiotic Moringa oleifera leaf extract using animal model. Twenty four male rats were randomly assigned to four groups and all the animals were given Phenylhydrazine orally to induce anaemia. Enterococcus durans was selected as probiotic supplement. Group 1 was provided with 300mg/kg of M.oleifera leaf extract. Group 2 was supplemented with 0.3 ml of E.durans along with 300mg/kg of M. oleifera leaf extract. Group 3 and 4 were fed with E.durans and iron supplement (1ml/rat) respectively. Blood samples were collected on a weekly basis and various haematological and biochemical parameters were analysed. The haemoglobin level was found to be higher with 14.9±0.25 g/dl for rats fed with probioticated M.oleifera leaf extract. E.durans has proliferated in gut which was verified through faecal and gut microbiota analysis. Hence, probiotic M.oleifera leaf extract was found an effectual nutraceutical supplement to treat anaemia.

show abstract

In vivo assessment of possible probiotic properties of Zymomonas mobilis in a Wistar rat model

Cited by 10 publications

References 14 publications

Sequence-based analysis of the microbial composition of water kefir from multiple sources

Sequence-based analysis of the microbial composition of water kefir from multiple sources

Aplicabilidades Terapêuticas De Zymomonas Mobilis Sobre Fatores Predisponentes Das Dislipidemias E Do Câncer Colorretal: Uma Revisão De Literatura

Influence of Probioticated Moringa Oleifera Leaf Extract for Treatment of Anaemia Using Animal Model

Contact Info

Product

Resources

About