In vivo antitussive activity of a pectic arabinogalactan isolated from Solanum virginianum L. in Guinea pigs

Raja, Washim; Nosálóvá, G; Ghosh, Kanika; Sivová, Veronika; Nosál, S; Ray, Bimalendu

doi:10.1016/j.jep.2014.08.012

Cited by 13 publications

(5 citation statements)

References 30 publications

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“…Antitussive activities have also been observed with polysaccharides such as arabinogalactans, arabinogalactanproteins and some others (Chattopadhyay et al, 2011;Chayed and Winnik, 2007;Raja et al, 2014;Saha et al, 2011;Sutovska et al, 2009). Regarding structure activity relationship of polysaccharides Nosalova et al (2013) emphasized the importance of uronic acid residue for activity.…”

Section: Discussionmentioning

confidence: 99%

Structural Elements and Cough Suppressing Activity of Polysaccharides from Zingiber officinale Rhizome

et al. 2015

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Zingiber officinale is used for the management of fever, bronchial asthma and cough for thousands of years. While the link to a particular indication has been established in human, the active principle of the formulation remains unknown. Herein, we have investigated a water extracted polysaccharides (WEP) containing fraction from its rhizome. Utilizing a traditional aqueous extraction protocol and using chemical, chromatographic and spectroscopic methods a fraction containing a branched glucan and polygalaturonan in a ratio of 59:1 was characterized. This glucan, which has a molecular mass of 36 kDa, is made up of terminal-, (1,4)- and (1,4,6)-linked α-Glcp residues. Oral administration of WEP in doses of 25 and 50 mg/kg body weight significantly inhibited the number of citric acid-induced cough efforts in guinea pigs. It does not alter the specific airway smooth muscle reactivity significantly. Thus, traditional aqueous extraction method provides molecular entities, which induces antitussive activity without addiction.

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Section: Discussionmentioning

confidence: 99%

Structural Elements and Cough Suppressing Activity of Polysaccharides from Zingiber officinale Rhizome

et al. 2015

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“…It is mainly used to treat respiratory diseases such as bronchial asthma [ 37 ]. S. virginianum L. has been used to manage fever, bronchial asthma, and cough for thousands of years [ 48 ].…”

Section: Solanaceae Familymentioning

confidence: 99%

Medicinal Plants of Solanum Species: The Promising Sources of Phyto-Insecticidal Compounds

Chidambaram

Alqahtani

Alghazwani

et al. 2022

Journal of Tropical Medicine

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Several medicinal plants have the potential to be a promising alternative pharmacological therapy for a variety of human illnesses. Many insects, including mosquitoes, are important vectors of deadly pathogens and parasites, which in the world’s growing human and animal populations can cause serious epidemics and pandemics. Medicinal plants continue to provide a large library of phytochemicals, which can be used to replace chemically synthesized insecticides, and utilization of herbal product-based insecticides is one of the best and safest alternatives for mosquito control. Identifying new effective phyto-derived insecticides is important to counter increasing insect resistance to synthetic compounds and provide a safer environment. Solanum genus (Solanaceae family or nightshades) comprises more than 2500 species, which are widely used as food and traditional medicine. All research publications on insecticidal properties of Solanaceae plants and their phytoconstituents against mosquitoes and other insects published up to July 2020 were systematically analyzed through PubMed/MEDLINE, Scopus, EBSCO, Europe PMC, and Google Scholar databases, with focus on species containing active phytoconstituents that are biodegradable and environmentally safe. The current state of knowledge on larvicidal plants of Solanum species, type of extracts, target insect species, type of effects, name of inhibiting bioactive compounds, and their lethal doses (LC50 and LC90) were reviewed in this study. These studies provide valuable information about the activity of various species of Solanum and their phytochemical diversity, as well as a roadmap for optimizing select compounds for botanical repellents against a variety of vectors that cause debilitating and life-threatening human diseases.

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“…Along similar lines, we have explored the therapeutic potential of Solanum virginianum L., a plant belonging to the Solanaceae family. The plant is well documented in the ancient manuscripts of Ayurveda for its beneficial effects against bronchial asthma and cough ( Raja et al, 2014 ). The current study, therefore, tested the biological activity of the plant extract against tuberculosis.…”

Section: Introductionmentioning

confidence: 99%

Robust anti-tubercular profile of Solanum virginianum extract in enhancing isoniazid bioavailability and curtailing stress tolerance in Mycobacterium smegmatis

Balkrishna,

Joshi,

Kabdwal

et al. 2024

Front. Microbiol.

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IntroductionThe formidable survival mechanisms employed by Mycobacterium tuberculosis (Mtb), combined with the low bioavailability of anti-tubercular drugs and their associated hepatotoxicity, worsen tuberculosis management. Traditional medicinal plants offer potential solutions to these challenges. This study focuses on exploring the anti-tubercular potential of Solanum virginianum against Mycobacterium smegmatis, mc2155.Methods and resultsHPTLC and UHPLC phytochemically characterized the hydro-methanolic extract of Solanum virginianum (SVE). SVE curtails the growth and viability of mc2155 under normal and in vitro stress conditions. The compromised cell wall integrity of mc2155 with SVE is depicted through scanning electron microscopy (SEM) while EtBr permeability assays and TLC-based comparative changes in lipids extraction addressed the integrity of the cell wall. Furthermore, SVE augmented the susceptibility of mc2155 towards Isoniazid (INH) through enhanced bioavailability. Adjunct treatment of SVE with INH demonstrated a markedly reduced survival of the intracellular bacilli. The study also uncovered the hepatoprotective potential of SVE in HepG2 cells.ConclusionThis research paves the way for deeper exploration into the potential of Solanum virginianum against virulent Mtb strains, emphasizing over the significance of traditional medicinal plants in tuberculosis treatment. Collectively, the findings suggest SVE as a potent candidate for independent or adjunct anti-tubercular therapy.

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In vivo antitussive activity of a pectic arabinogalactan isolated from Solanum virginianum L. in Guinea pigs

Cited by 13 publications

References 30 publications

Structural Elements and Cough Suppressing Activity of Polysaccharides from Zingiber officinale Rhizome

Structural Elements and Cough Suppressing Activity of Polysaccharides from Zingiber officinale Rhizome

Medicinal Plants of Solanum Species: The Promising Sources of Phyto-Insecticidal Compounds

Robust anti-tubercular profile of Solanum virginianum extract in enhancing isoniazid bioavailability and curtailing stress tolerance in Mycobacterium smegmatis

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