In vivo antimutagenic effect of vitamins C and E against rifampicin-induced chromosome aberrations in mouse bone-marrow cells

Aly, Fawzia A. E.; Donya, Souria M.

doi:10.1016/s1383-5718(02)00037-2

Cited by 24 publications

(16 citation statements)

References 29 publications

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“…Vitamin-C, E and beta-carotene showed reduction in DNA damage induced by gammaray in human lymphocytes 34,35 . In another study it was reported that vitamin-C and E induced reduction in rifampicin induced chromosomal aberrations in mouse bone marrow cells 36 . Beta sitosterol is gaining importance these days on account of its wide range of biological activity.…”

Section: Discussionmentioning

confidence: 93%

Anticlastogenic Effect of Ulva Fasciata, Against Cyclophosphamide and Mitomycin C Induced Chromosomal Damage in Swiss Albino Mice

Dolpady

Vijayalaxmi

2018

Preprint

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ABSTRACT:Chemoprevention is a strategy to reduce the incidence of human cancer either by inhibiting initiation of carcinogenesis or by preventing exposure to carcinogens, by the use of plant or animal derived ingredients. In the present study we investigated the anticlastogenic effect of ethanol extract of Ulva fasciata, a green seaweed, against the chromosomal aberration and micronucleus induced by the anticancer drugs cyclophosphamide and mitomycin C. Three doses of extract (25, 50 and 75 mg/kg.b.w) was given by oral gavage for 5 days at 24 hr. intervals and on the 5 th day, CP (25 and 50mg/kg.b.w) or MMC (1 and 2mg/kg.b.w) were intraperitoneally injected and 24hrs. later micronucleus and chromosomal aberrations assays were performed. Our results show that Ulva extract gave significant protection against the CP and MMC induced damages by reducing micronucleus and chromosomal aberrations. The protection imparted by Ulva could be due to the synergistic and/or additive effects of biologically active ingredients present in the seaweed.

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Section: Discussionmentioning

confidence: 93%

Anticlastogenic Effect of Ulva Fasciata, Against Cyclophosphamide and Mitomycin C Induced Chromosomal Damage in Swiss Albino Mice

Dolpady

Vijayalaxmi

2018

Preprint

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“…Additionally, ascorbic acid also reduced chromosome aberrations induced by rifampicin, an antituberculosis agent, when mice were co-treated with both compounds. Repeated doses of vitamin C reduced the percentage of rifampicin-induced DNA damage in a significant and dose-dependent manner (Aly and Donya, 2002). Bijur et al (1997) suggest that the time at which vitamin C is administered in relation to oxidative stress exposure has an impact on its antimutagenic activity, which may explain the conflicting results concerning the effectiveness of ascorbic acid as a cancer chemopreventive agent.…”

Section: Discussionmentioning

confidence: 99%

DNA damage protective effect of honey-sweetened cashew apple nectar in Drosophila melanogaster

et al. 2016

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Fruits and derivatives, such as juices, are complex mixtures of chemicals, some of which may have mutagenic and/or carcinogenic potential, while others may have antimutagenic and/or anticancer activities. The modulating effects of honey-sweetened cashew apple nectar (HSCAN), on somatic mutation and recombination induced by ethyl methanesulfonate (EMS) and mitomycin C (MMC) were evaluated with the wing spot test in Drosophila melanogaster using co- and post-treatment protocols. Additionally, the antimutagenic activity of two HSCAN components, cashew apple pulp and honey, in MMC-induced DNA damage was also investigated. HSCAN reduced the mutagenic activity of both EMS and MMC in the co-treatment protocol, but had a co-mutagenic effect when post-administered. Similar results were also observed with honey on MMC mutagenic activity. Cashew apple pulp was effective in exerting protective or enhancing effects on the MMC mutagenicity, depending on the administration protocol and concentration used. Overall, these results indicate that HSCAN, cashew apple and honey seem capable of modulating not only the events that precede the induced DNA damages, but also the Drosophila DNA repair processes involved in the correction of EMS and MMC-induced damages.

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“…RSV can stabilize hemoglobin through the connection of the three hydroxyls groups of stilbene chains α of Pro95, Thr134 and Asp126 forming hydrogen bonds [ 62 ], leading to attenuation of high levels of oxidation. Other reports showed that other antioxidants, such as vitamin supplements (vitamins C and E) may also prove protective against methemoglobinemia and genotoxicity caused by anti-leprotic drugs in leprosy patients [ 11 , 63 , 64 ].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Protective Effect and Antioxidant Mechanism of Resveratrol Induced by Dapsone Hydroxylamine in Human Cells

Albuquerque¹,

Malcher

Amado³

et al. 2015

PLoS ONE

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Dapsone (DDS) hydroxylamine metabolites cause oxidative stress- linked adverse effects in patients, such as methemoglobin formation and DNA damage. This study evaluated the ameliorating effect of the antioxidant resveratrol (RSV) on DDS hydroxylamine (DDS-NHOH) mediated toxicity in vitro using human erythrocytes and lymphocytes. The antioxidant mechanism was also studied using in-silico methods. In addition, RSV provided intracellular protection by inhibiting DNA damage in human lymphocytes induced by DDS-NHOH. However, whilst pretreatment with RSV (10–1000 μM significantly attenuated DDS-NHOH-induced methemoglobinemia, but it was not only significantly less effective than methylene blue (MET), but also post-treatment with RSV did not reverse methemoglobin formation, contrarily to that observed with MET. DDS-NHOH inhibited catalase (CAT) activity and reactive oxygen species (ROS) generation, but did not alter superoxide dismutase (SOD) activity in erythrocytes. Pretreatment with RSV did not alter these antioxidant enzymes activities in erythrocytes treated with DDS-NHOH. Theoretical calculations using density functional theory methods showed that DDS-NHOH has a pro-oxidant effect, whereas RSV and MET have antioxidant effect on ROS. The effect on methemoglobinemia reversion for MET was significantly higher than that of RSV. These data suggest that the pretreatment with resveratrol may decrease heme-iron oxidation and DNA damage through reduction of ROS generated in cells during DDS therapy.

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In vivo antimutagenic effect of vitamins C and E against rifampicin-induced chromosome aberrations in mouse bone-marrow cells

Cited by 24 publications

References 29 publications

Anticlastogenic Effect of Ulva Fasciata, Against Cyclophosphamide and Mitomycin C Induced Chromosomal Damage in Swiss Albino Mice

Anticlastogenic Effect of Ulva Fasciata, Against Cyclophosphamide and Mitomycin C Induced Chromosomal Damage in Swiss Albino Mice

DNA damage protective effect of honey-sweetened cashew apple nectar in Drosophila melanogaster

In Vitro Protective Effect and Antioxidant Mechanism of Resveratrol Induced by Dapsone Hydroxylamine in Human Cells

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