In vivo antidiabetic actions of naglivan, an organic vanadyl compound in streptozotocin-induced diabetes

Effect of Sclerocarya birrea (Anacardiaceae) stem bark methylene chloride/methanol extract on streptozotocin-diabetic rats

“…Despite the reduction food and fluid intake by diabetic treated rats, at the end of 3 weeks of treatment, there was no loss in body weight when the effective dose of the plant extract was administrated, indicating that Sclerocarya birrea extract possibly compensated for the energy supplied from food intake, or contributed to the improved metabolism in diabetic treated animals. It has long been known that in the STZ-induced diabetes mellitus, the rise in blood glucose is accompanied by an increase in plasma cholesterol, triglycerides and urea (Cam et al, 1993;Pari and Saravanan, 2002). The Sclerocarya birrea dose (300 mg/kg body weight per day) used in this study had a tendency to reduce plasma cholesterol, triglyceride and urea levels, but the difference between treated diabetic and untreated diabetic groups did not reach statistical significance after 3 weeks.…”

The hypoglycemic activity of Lithocarpus polystachyus Rehd. leaves in the experimental hyperglycemic rats

“…Three weeks of ST-3 administration reduced the hyperglycemia significantly as well as inhibited the decline of serum insulin in the T1DM rats. It has long been known that in the STZ-induced T1DM rats, the rise in blood glucose is accompanied by an increase in TG, TC, BUN and CREA (Cam et al, 1993;Pushparaj et al, 2001). Treatment with ST-3 reversed some of these parameters, such as TG, BUN and BUN/Cr to near normal.…”

and antihyperglycemia effects of resvertrol and its derivative on alloxan diabetic rabbits

“…These findings indirectly show that the blood glucose levels in the groups treated with resveratrol and its derivative may have been lowered not by insulin but by derivatives; this is because almost all of the pancreatic islet beta cells were destroyed and therefore resulted in insulin deficiency [17].…”