In vivo anti-melanogenesis activity and in vitro skin permeability of niacinamide-loaded flexible liposomes (Bounsphere™)

Min-Hye, Lee; Lee, Kyung-Kwan; Park, Mi-Hee; Hyun, Seung-Su; Kahn, Soo-Youn; Joo, Kwang-Sik; Kang, Hee-Cheol; Kwon, Woo-Taeg

doi:10.1016/j.jddst.2015.12.008

Cited by 25 publications

(15 citation statements)

References 20 publications

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“…Terlebih lagi, NA melindungi kulit dari ROS dan berfungsi sebagai pembawa utama pada kulit, mencegah hilangnya kelembaban dengan meningkatkan produksi ceramides dan asam lemak. NA sangat stabil di bawah paparan radiasi UV, panas, oksigen, asam, dan basa 58 .…”

Section: Niacinamideunclassified

“…Hasil penelitian yang dilakukan untuk mengevaluasi formulasi dan karakteristik liposom fleksibel dari 2% Niacinamide yang terdiri dari membran lipid biokompatibel dengan dipotassium glycyrrhizate (DPG) menunjukkan peningkatan aktivitas pemutihan kulit dan memiliki kestabilan yang baik, sehingga liposome dapat menjadi sistem penghantaran baru untuk meningkatkan efektifitas permeasi transdermal suatu zat pemutih kulit 58 .…”

Section: Liposom Flexibel Niacinamideunclassified

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Whitening Agent : Mekanisme, Sumber dari Alam dan Teknologi Formulasinya

Soyata

Chaerunisaa

2021

Maj. Farmasetika

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Sekarang ini adanya keinginan alamiah untuk tampil cantik khususnya pada kaum wanita telah meningkatkan kesadaran tentang pentingnya perawatan kulit dan warnanya, untuk itu upaya yang dapat dilakukan adalah memutihkan kulit dengan menekan produksi melanin menggunakan whitening agent, sehingga dilakukan penulisan artikel review ini dengan tujuan mengetahui jenis-jenis whitening agent, mekanismenya dan penggunaan teknologi formulasinya. Beberapa contoh whitening agent yaitu hydroquinone, ascorbic acid, kojic acid, arbutin, niacinamide, retinoid, azelaic acid, namun beberapa zat ini dapat menimbulkan permasalahan pada kulit seperti iritasi, dermatitis, alergi dan kanker kulit sehingga sekarang ini dapat digunakan whitening agent dari alam yang minim efek samping seperti temulawak, cendana, teripang, dan prunus. Mekanisme utama whitening agent adalah menghambat enzim tirosinasedan, dan untuk memaksimalkan efek whitening pada kulit telah dikembangkan teknologi formulasi menggunakan beberapa metode penghantaran seperti liposom, nanopartikel, solid lipid nanopartikel dan mikroemulsi.

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Section: Niacinamideunclassified

Section: Liposom Flexibel Niacinamideunclassified

Whitening Agent : Mekanisme, Sumber dari Alam dan Teknologi Formulasinya

Soyata

Chaerunisaa

2021

Maj. Farmasetika

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“…To increase the skin penetration of drugs, various strategies have been used, such as microemulsions [ 8 ], liposomes [ 9 ], ultrasound [ 10 ], nanofibers [ 11 ], niosomes [ 12 ], and magnetophoresis [ 13 ]. Liposomes are spherical phospholipid bilayer nanoparticles that can entrap both hydrophilic and lipophilic drugs.…”

Section: Introductionmentioning

confidence: 99%

Development of Ultradeformable Liposomes with Fatty Acids for Enhanced Dermal Rosmarinic Acid Delivery

2021

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This study aimed to develop ultradeformable liposomes (ULs) with fatty acids, namely, oleic, linoleic, and linolenic acid, to improve the skin penetration of rosmarinic acid. This study also investigated the vesicle-skin interaction and skin penetration pathway of ULs with fatty acids using the co-localization technique of multifluorescently labeled particles. The prepared ULs were characterized in terms of size, surface charge, size distribution, shape, % entrapment efficiency (% EE), and % loading efficiency (% LE). The prepared ULs with fatty acids had an average particle size between 50.37 ± 0.3 and 59.82 ± 17.3 nm with a size distribution within an acceptable range and exhibited a negative surface charge. The average % EE and % LE were 9 and 24.02, respectively. The in vitro skin penetration study found that ULs with oleic acid could significantly increase the skin penetration of rosmarinic acid compared to ULs. According to confocal laser scanning microscopy observations, this study suggested that UL vesicles attach to the skin before releasing the entrapped drug to penetrate the skin. These findings suggested that ULs with oleic acid penetrated the skin via the transfollicular pathway as a major penetration pathway.

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“…The values are measured from five different facial areas, namely, the forehead, nose, corner of/the skin below the eyes, and cheeks. Studies 6‐10 using the Janus‐III measurement system have been increasing owing to its convenience and diverse measuring characteristics. In our previous study, 5 we revealed the consistency and reliability of the system with repeatedly measured values.…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of skin characteristics evaluation by a dermatologist and the Janus‐III measurement system

Leem

Kim

et al. 2020

Skin Research and Technology

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Background The Janus‐III measurement system evaluates the overall skin characteristics such as skin pore, wrinkle, sebum, porphyrin, skin pigmentation, and skin color using high‐resolution facial images. The values are measured from five different facial areas, namely, the forehead, nose, corner of/skin below the eyes, and cheeks. Owing to its convenience and diverse measuring characteristics, Janus‐III has been widely used in skin research and the cosmetic industry in Korea. In our previous study, we revealed the consistency and reliability of the system with repeatedly measured values. Its measuring performance was investigated statistically, but to make it more reliable for academic skin research, additional verification by a professional dermatologist is needed. Materials and Methods In this study, we conducted comparative analysis of three skin characteristics (pigmented spot, skin color, and eye wrinkle) by a dermatologist and the Janus‐III measurement system. We utilized 330 image data that were cropped from the whole facial images of 330 different participants to avoid correlation among the three measuring items. Pearson's correlation coefficient exhibited similar patterns between the system and the dermatologist's findings. Results The main finding of our study was that the measured value of skin characteristics by the Janus‐III system showed clear correlation with the values evaluated by a dermatologist, especially in a pigmented spot. Conclusion Therefore, it would be a plausible idea to consider the Janus‐III system for specialized research of skin characteristics even with a small sample size.

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In vivo anti-melanogenesis activity and in vitro skin permeability of niacinamide-loaded flexible liposomes (Bounsphere™)

Cited by 25 publications

References 20 publications

Whitening Agent : Mekanisme, Sumber dari Alam dan Teknologi Formulasinya

Whitening Agent : Mekanisme, Sumber dari Alam dan Teknologi Formulasinya

Development of Ultradeformable Liposomes with Fatty Acids for Enhanced Dermal Rosmarinic Acid Delivery

Comparative analysis of skin characteristics evaluation by a dermatologist and the Janus‐III measurement system

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