In Vivo Angiogenic Activity of Interleukins

The expression of functionally‐coupled B2‐bradykinin receptors in human corneal epithelial cells and their pharmacological characterization with agonists and antagonists

“…Schild analyses of the Hoe‐140 antagonist data yielded apparent antagonist potencies of 2.9 n m ; pA 2 = 8.54 ± 0.06, slope = 1.04 ± 0.08, n = 4 (Figures 4 and 5). Antagonist data for D‐Arg 0 [Hyp 3 , Thi 5,8 , DPhe 7 ]‐BK in CEPI‐17‐CL4 cells were: apparent K b = 371 n m ; apparent p K B = 6.43 ± 0.08 ( n = 4) (Figure 6). The antagonist potency of Hoe‐140 against BK in P‐CEPI cells was 8.4 ± 1.8 n m (p K i = 8.11 ± 0.12, n = 4), and it was 2.7 ± 0.76 n m (p K i = 8.6 ± 0.15, n = 5) in CEPI‐17‐CL4 cells (Figure 7).…”

The expression of functionally‐coupled B2‐bradykinin receptors in human corneal epithelial cells and their pharmacological characterization with agonists and antagonists

“…Schild analyses of the Hoe‐140 antagonist data yielded apparent antagonist potencies of 2.9 n m ; pA 2 = 8.54 ± 0.06, slope = 1.04 ± 0.08, n = 4 (Figures 4 and 5). Antagonist data for D‐Arg 0 [Hyp 3 , Thi 5,8 , DPhe 7 ]‐BK in CEPI‐17‐CL4 cells were: apparent K b = 371 n m ; apparent p K B = 6.43 ± 0.08 ( n = 4) (Figure 6). The antagonist potency of Hoe‐140 against BK in P‐CEPI cells was 8.4 ± 1.8 n m (p K i = 8.11 ± 0.12, n = 4), and it was 2.7 ± 0.76 n m (p K i = 8.6 ± 0.15, n = 5) in CEPI‐17‐CL4 cells (Figure 7).…”

Impact of co-blocking the costimulatory signals on immune-related genes after high-risk rabbit corneal allograft using 2nd-generation DNA sequencing technology

“…IL-1β is the dominant form. BenEzra et al (1990) reported that IL-1 strongly influences the formation of new blood vessels, and copy number variation affects the occurrence of corneal rejection. Under antigen stimulation, IL-1 levels are significantly increased to regulate the acute inflammatory phase, produce chemotaxis, and activate inflammatory cells and antigen-presenting cells, thereby activating T cells and B cells.…”

Microglia and Interleukin-1β in Ischemic Retinopathy Elicit Microvascular Degeneration Through Neuronal Semaphorin-3A

“…On one hand, IL-1β is primarily associated with angiogenesis. 8,9,18,43 Whereas, on the other hand, IL-1β has also been linked to retinal vascular degeneration 44 ; this latter aspect remains unexplained. Although microglia are thought to contribute significantly to the generation of cytokines in neural tissue, 2,45 their involvement in retinovascular degeneration is elusive; along these lines, microglia (nonactivated) are reported to participate in normal developmental angiogenesis.…”

The expression of functionally‐coupled B2‐bradykinin receptors in human corneal epithelial cells and their pharmacological characterization with agonists and antagonists

“…Schild analyses of the Hoe‐140 antagonist data yielded apparent antagonist potencies of 2.9 n m ; pA 2 = 8.54 ± 0.06, slope = 1.04 ± 0.08, n = 4 (Figures 4 and 5). Antagonist data for D‐Arg 0 [Hyp 3 , Thi 5,8 , DPhe 7 ]‐BK in CEPI‐17‐CL4 cells were: apparent K b = 371 n m ; apparent p K B = 6.43 ± 0.08 ( n = 4) (Figure 6). The antagonist potency of Hoe‐140 against BK in P‐CEPI cells was 8.4 ± 1.8 n m (p K i = 8.11 ± 0.12, n = 4), and it was 2.7 ± 0.76 n m (p K i = 8.6 ± 0.15, n = 5) in CEPI‐17‐CL4 cells (Figure 7).…”

Impact of co-blocking the costimulatory signals on immune-related genes after high-risk rabbit corneal allograft using 2nd-generation DNA sequencing technology

“…IL-1β is the dominant form. BenEzra et al (1990) reported that IL-1 strongly influences the formation of new blood vessels, and copy number variation affects the occurrence of corneal rejection. Under antigen stimulation, IL-1 levels are significantly increased to regulate the acute inflammatory phase, produce chemotaxis, and activate inflammatory cells and antigen-presenting cells, thereby activating T cells and B cells.…”

Microglia and Interleukin-1β in Ischemic Retinopathy Elicit Microvascular Degeneration Through Neuronal Semaphorin-3A

“…On one hand, IL-1β is primarily associated with angiogenesis. 8,9,18,43 Whereas, on the other hand, IL-1β has also been linked to retinal vascular degeneration 44 ; this latter aspect remains unexplained. Although microglia are thought to contribute significantly to the generation of cytokines in neural tissue, 2,45 their involvement in retinovascular degeneration is elusive; along these lines, microglia (nonactivated) are reported to participate in normal developmental angiogenesis.…”

The expression of functionally‐coupled B2‐bradykinin receptors in human corneal epithelial cells and their pharmacological characterization with agonists and antagonists

“…Schild analyses of the Hoe‐140 antagonist data yielded apparent antagonist potencies of 2.9 n m ; pA 2 = 8.54 ± 0.06, slope = 1.04 ± 0.08, n = 4 (Figures 4 and 5). Antagonist data for D‐Arg 0 [Hyp 3 , Thi 5,8 , DPhe 7 ]‐BK in CEPI‐17‐CL4 cells were: apparent K b = 371 n m ; apparent p K B = 6.43 ± 0.08 ( n = 4) (Figure 6). The antagonist potency of Hoe‐140 against BK in P‐CEPI cells was 8.4 ± 1.8 n m (p K i = 8.11 ± 0.12, n = 4), and it was 2.7 ± 0.76 n m (p K i = 8.6 ± 0.15, n = 5) in CEPI‐17‐CL4 cells (Figure 7).…”

Impact of co-blocking the costimulatory signals on immune-related genes after high-risk rabbit corneal allograft using 2nd-generation DNA sequencing technology

“…IL-1β is the dominant form. BenEzra et al (1990) reported that IL-1 strongly influences the formation of new blood vessels, and copy number variation affects the occurrence of corneal rejection. Under antigen stimulation, IL-1 levels are significantly increased to regulate the acute inflammatory phase, produce chemotaxis, and activate inflammatory cells and antigen-presenting cells, thereby activating T cells and B cells.…”

Microglia and Interleukin-1β in Ischemic Retinopathy Elicit Microvascular Degeneration Through Neuronal Semaphorin-3A

“…On one hand, IL-1β is primarily associated with angiogenesis. 8,9,18,43 Whereas, on the other hand, IL-1β has also been linked to retinal vascular degeneration 44 ; this latter aspect remains unexplained. Although microglia are thought to contribute significantly to the generation of cytokines in neural tissue, 2,45 their involvement in retinovascular degeneration is elusive; along these lines, microglia (nonactivated) are reported to participate in normal developmental angiogenesis.…”