In vivo and in vitro hepatotoxicity and metabolism of acetaminophen in syrian hamsters

Acetaminophen Overdose Enhances Early Cholangiocarcinoma in Opisthorchiasis Hamsters

“…Opisthorchiasis induced hepatobiliary disease is associated with chronic inflammation, (Bility and Sripa, 2014;Sergei et al, 2010) and is an important determinant for the development of cholangiocarcinoma (CCA), or bile duct cancer (IARC, 2011). Exogenous nitrosamine from fermented foods, and drinking alcohol are associated with increased CCA development by increasing inflammation (Honjo et al, 2005;Juasook et al, 2012;Juasook et al, and Fischer, 1983;Rosen et al, 1983;Sasaki et al, 1983;Savides and Oehme, 1983;Miller and Jollow, 1984;Lupo et al, 1987;Miller and Jollow, 1987;Madhu et al, 1989;Knight et al, 2001;Lee et al, 2004) and has been shown to increase/induce inflammation in humans/animal/in vitro.…”

Acetaminophen Overdose Enhances Early Cholangiocarcinoma in Opisthorchiasis Hamsters

“…Opisthorchiasis induced hepatobiliary disease is associated with chronic inflammation, (Bility and Sripa, 2014;Sergei et al, 2010) and is an important determinant for the development of cholangiocarcinoma (CCA), or bile duct cancer (IARC, 2011). Exogenous nitrosamine from fermented foods, and drinking alcohol are associated with increased CCA development by increasing inflammation (Honjo et al, 2005;Juasook et al, 2012;Juasook et al, and Fischer, 1983;Rosen et al, 1983;Sasaki et al, 1983;Savides and Oehme, 1983;Miller and Jollow, 1984;Lupo et al, 1987;Miller and Jollow, 1987;Madhu et al, 1989;Knight et al, 2001;Lee et al, 2004) and has been shown to increase/induce inflammation in humans/animal/in vitro.…”

Acetaminophen Overdose Enhances Early Cholangiocarcinoma in Opisthorchiasis Hamsters

“…Opisthorchiasis induced hepatobiliary disease is associated with chronic inflammation, (Bility and Sripa, 2014;Sergei et al, 2010) and is an important determinant for the development of cholangiocarcinoma (CCA), or bile duct cancer (IARC, 2011). Exogenous nitrosamine from fermented foods, and drinking alcohol are associated with increased CCA development by increasing inflammation (Honjo et al, 2005;Juasook et al, 2012;Juasook et al, and Fischer, 1983;Rosen et al, 1983;Sasaki et al, 1983;Savides and Oehme, 1983;Miller and Jollow, 1984;Lupo et al, 1987;Miller and Jollow, 1987;Madhu et al, 1989;Knight et al, 2001;Lee et al, 2004) and has been shown to increase/induce inflammation in humans/animal/in vitro.…”

Acetaminophen Overdose Enhances Early Cholangiocarcinoma in Opisthorchiasis Hamsters

“…Opisthorchiasis induced hepatobiliary disease is associated with chronic inflammation, (Bility and Sripa, 2014;Sergei et al, 2010) and is an important determinant for the development of cholangiocarcinoma (CCA), or bile duct cancer (IARC, 2011). Exogenous nitrosamine from fermented foods, and drinking alcohol are associated with increased CCA development by increasing inflammation (Honjo et al, 2005;Juasook et al, 2012;Juasook et al, and Fischer, 1983;Rosen et al, 1983;Sasaki et al, 1983;Savides and Oehme, 1983;Miller and Jollow, 1984;Lupo et al, 1987;Miller and Jollow, 1987;Madhu et al, 1989;Knight et al, 2001;Lee et al, 2004) and has been shown to increase/induce inflammation in humans/animal/in vitro.…”