In Vivo and In Vitro Antibacterial Efficacy of PDS Plus (Polidioxanone with Triclosan) Suture

Ming, Xintian; Rothenburger, Stephen; Nichols, Michele

doi:10.1089/sur.2007.061

Cited by 104 publications

(66 citation statements)

References 14 publications

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“…(25,26) Recent studies have shown that surgical site infections can be reduced through the use of sutures that have been impregnated with antibiotics. (27)(28)(29)(30) The present study was not without limitations. Due to the fact that it was a retrospective study, it may have been subject to selection bias.…”

Section: Discussionmentioning

confidence: 85%

Incidence of postoperative wound infections after open tendo Achilles repairs

Marican

Fook‐Chong

Rikhraj

2015

smedj

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Section: Discussionmentioning

confidence: 85%

Incidence of postoperative wound infections after open tendo Achilles repairs

Marican

Fook‐Chong

Rikhraj

2015

smedj

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“…15 Triclosan coating has shown effectiveness in vitro against strains of Staphylococcus aureus, Staphylococcus epidermidis, MRSA, methicillin-resistant Staphylococcus epidermidis (MRSE), vancomycin-resistant Enterococcus faecalis, Pseudomonas aeruginosa, and Escherichia coli 16,17 and has proven beneficial in animal models (rat and guinea pig). 7,[18][19][20] Recently, a new suture material has emerged on the market that is characterized by barbs projecting from a monofilament base. To our knowledge, three different barbed sutures are currently on the market: Quill TM (Surgical Specialties Corporation), V-loc TM (Covidien), and Stratafix TM (Ethicon).…”

mentioning

confidence: 99%

Bacterial adhesion to suture material in a contaminated wound model: Comparison of monofilament, braided, and barbed sutures

Dhom

Bloes

Peschel

et al. 2016

Journal Orthopaedic Research

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Contaminated suture material plays an important role in the physiopathology of surgical site infections. Recently, suture material has been developed characterized by barbs projecting from a monofilament base. Claimed advantages for barbed sutures are a shortened wound closure time and reduced maximum wound tension. It has also been suggested that these sutures would be advantageous microbiologically. The aim of this study was to test the microbiological characteristics of the barbed Quill in comparison to the monofilament Ethilon II and the braided sutures Vicryl and triclosan-coated Vicryl Plus. In our study, sutures were cultivated on color-change agar with Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa and the halo size was measured. In a second study arm with longer cultivation bacterial growth was followed by antibiotic treatment. Ethilon II and Quill showed good comparable results, whereas large halos were found around Vicryl. Vicryl Plus results depended on triclosan sensitivity. After longer bacterial cultivation and antibiotic treatment, halos were up to 3.6 times smaller on Quill than on Vicryl (p < 0.001), but 1.4 times larger than on Ethilon II (p < 0.001) regarding S. aureus. Confocal microscopy analysis showed bacterial colonization between the braided filaments on Vicryl and beneath the barbs on Quill. From a microbiological perspective, barbed sutures can be recommended in aseptic surgery, but should only be used carefully in septic surgery.

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“…на мировом рынке шовных материалов широко позиционируются нити, содержащие антисептик триклозан [6,14]. в исследованиях «in vitro» и «in vivo» доказано их достаточно выраженное и пролонгированное действие на широкий спектр микроорганизмов [15]. не менее эффективным представляется использование биологически активных нитей с антибиотиками [5] действием: антибактериальным и стимулирую-щим регенеративные процессы [12].…”

Section: Discussionunclassified

The development of new biologically active suture materials and using them in the abdominal surgery

Mokhov¹,

Sergeev²,

Serov³

2013

Novosti Khirurgii

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Цель. улучшение результатов операций на органах брюшной полости и брюшной стенке на основе разработки и применения в клинической практике новых биологически активных шовных материалов.Материал и методы. в эксперименте «in vitro» и «in vivo» с помощью различных методик (бактери-ологических, цитологических, гистологических, электронной микроскопии, тензометрии и др.) изучено 7 видов биологически активных нитей на предмет возможности использования их в качестве хирургического шовного материала. для исследования эффективности применения биологически активных шовных мате-риалов в клинике проведен анализ ближайших результатов оперативных вмешательств у 626 пациентов с экстренной и плановой абдоминальной хирургической патологией (брюшные грыжи, острый аппендицит, острый и хронический холециститы, прободная язва желудка и двенадцатиперстной кишки, кишечная не-проходимость, травмы живота, ургентная гинекологическая патология и др.).Результаты. с учетом данных, полученных при выполнении экспериментальных исследований, во всероссийском научно-исследовательском институте синтетического волокна (ФГуп вниисв) разра-ботаны шовные материалы с антимикробной активностью («никант», «тверан-хЦ-ккр») и комплексным (антимикробным и стимулирующим репаративные процессы) биологическим действием («никант-п», «тверан-хЦГ-ккр»). использование созданных шовных материалов в клинике при операциях на органах брюшной полости и брюшной стенке позволило существенно улучшить результаты выполненных хирурги-ческих вмешательств за счет уменьшения числа местных послеоперационных осложнений инфекционного генеза.Заключение. результаты проведенных исследований позволяют рекомендовать разработанные био-логически активные шовные материалы к использованию в широкой клинической практике. Ключевые слова: биологически активные хирургические шовные материалы, изучение в эксперименте, применение в абдоминальной хирургииObjectives. The improvement of operation results on the organs of the abdominal cavity and abdominal wall basing on the development and application of new biologically active suture materials in clinical practice.Methods. 7 types of biologically active threads were investigated for their probability to be used as surgical suture materials «in vitro» and «in vivo» experiment by means of various techniques (bacteriological, cytological, histological, electronic microscopy, tensometry and etc.). To analyze the efficiency of biologically active suture materials application in clinic the comparative study of the recent urgent and planned operation results in 626 patients with abdominal pathology (abdominal hernias, acute appendicitis, acute and chronic cholecystitis, perforation of gastric and duodenal ulcers, intestinal obstruction, abdominal injuries, urgent gynecology etc.) has been carried out.Results. According to the data received at the pilot studies in All-Russian Scientific Research Institute of Synthetic Fiber (Federal State Unitary Enterprise (ARSRISF) the suture materials with antimicrobial activity ("Nikant", "Tveran-HC") and complex biol...

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In Vivo and In Vitro Antibacterial Efficacy of PDS Plus (Polidioxanone with Triclosan) Suture

Abstract: Polydioxanone suture with triclosan had activity in vitro against S. aureus, MRSA, E. coli, S. epidermidis, MRSE, and K. pneumoniae that persisted for as long as three weeks. In animal models, polydioxanone suture with triclosan inhibited in vivo colonization by S. aureus and E. coli.

Cited by 104 publications

References 14 publications

Incidence of postoperative wound infections after open tendo Achilles repairs

Incidence of postoperative wound infections after open tendo Achilles repairs

Bacterial adhesion to suture material in a contaminated wound model: Comparison of monofilament, braided, and barbed sutures

The development of new biologically active suture materials and using them in the abdominal surgery

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