In vivo and in vitro production of haemopoietic colony-stimulating activity by murine cell lines of different origin: a frequent finding

Mechanisms of Paraneoplastic Syndromes in Mice Bearing a Spontaneous Lung Adenocarcinoma

“…The production and secretion of GM-CSF by tumor cell lines and by human and murine tumors have been frequently observed [32]. This observation was confirmed in the experimental lung tumor P07, since we detected GM-CSF in the supernatant of 24-hour-cultured tumor cells [33].…”

Mechanisms of Paraneoplastic Syndromes in Mice Bearing a Spontaneous Lung Adenocarcinoma

“…The production and secretion of GM-CSF by tumor cell lines and by human and murine tumors have been frequently observed [32]. This observation was confirmed in the experimental lung tumor P07, since we detected GM-CSF in the supernatant of 24-hour-cultured tumor cells [33].…”

Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model

“…On the contrary, GM-CSF engineering of another murine model (B16 melanoma) gave good results [138] and prompted clinical studies. B16 melanoma did not produce spontaneously GM-CSF whereas TS/A abundantly secreted CSFs [16]. The spontaneous CSF production in TS/A did not hamper tumor growth but likely contributed to the tumor-promoting environment, showing that similar cytokines could play opposite roles in tumors of different origin.…”

Regulation of leukocyte binding to endothelial tissues by tumor‐derived GM‐CSF

“…Tumor-derived colony-stimulating factors have been detected in murine and human hosts bearing non-hematologic cancers (Fu et al, 1990;Nicoletti et al, 1989;Tsuchiya et al, 1988). There is evidence that GM-CSF can enhance the in vitro migration and proliferation of endothelial cells, indicating that this cytokine may play a role in the vascularization of tumors, which is crucial for their growth (Folkman a n d Klagsbrun, 1987).…”

Mechanisms of Paraneoplastic Syndromes in Mice Bearing a Spontaneous Lung Adenocarcinoma

“…The production and secretion of GM-CSF by tumor cell lines and by human and murine tumors have been frequently observed [32]. This observation was confirmed in the experimental lung tumor P07, since we detected GM-CSF in the supernatant of 24-hour-cultured tumor cells [33].…”

Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model

“…On the contrary, GM-CSF engineering of another murine model (B16 melanoma) gave good results [138] and prompted clinical studies. B16 melanoma did not produce spontaneously GM-CSF whereas TS/A abundantly secreted CSFs [16]. The spontaneous CSF production in TS/A did not hamper tumor growth but likely contributed to the tumor-promoting environment, showing that similar cytokines could play opposite roles in tumors of different origin.…”

Regulation of leukocyte binding to endothelial tissues by tumor‐derived GM‐CSF

“…Tumor-derived colony-stimulating factors have been detected in murine and human hosts bearing non-hematologic cancers (Fu et al, 1990;Nicoletti et al, 1989;Tsuchiya et al, 1988). There is evidence that GM-CSF can enhance the in vitro migration and proliferation of endothelial cells, indicating that this cytokine may play a role in the vascularization of tumors, which is crucial for their growth (Folkman a n d Klagsbrun, 1987).…”

Mechanisms of Paraneoplastic Syndromes in Mice Bearing a Spontaneous Lung Adenocarcinoma

“…The production and secretion of GM-CSF by tumor cell lines and by human and murine tumors have been frequently observed [32]. This observation was confirmed in the experimental lung tumor P07, since we detected GM-CSF in the supernatant of 24-hour-cultured tumor cells [33].…”

Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model

“…On the contrary, GM-CSF engineering of another murine model (B16 melanoma) gave good results [138] and prompted clinical studies. B16 melanoma did not produce spontaneously GM-CSF whereas TS/A abundantly secreted CSFs [16]. The spontaneous CSF production in TS/A did not hamper tumor growth but likely contributed to the tumor-promoting environment, showing that similar cytokines could play opposite roles in tumors of different origin.…”

Regulation of leukocyte binding to endothelial tissues by tumor‐derived GM‐CSF

“…Tumor-derived colony-stimulating factors have been detected in murine and human hosts bearing non-hematologic cancers (Fu et al, 1990;Nicoletti et al, 1989;Tsuchiya et al, 1988). There is evidence that GM-CSF can enhance the in vitro migration and proliferation of endothelial cells, indicating that this cytokine may play a role in the vascularization of tumors, which is crucial for their growth (Folkman a n d Klagsbrun, 1987).…”