In vivo 1H NMR spectroscopy of individual human brain metabolites at moderate field strengths

Trabesinger, Andreas; Meier, D.; Boesiger, Peter

doi:10.1016/j.mri.2003.08.029

Cited by 30 publications

(17 citation statements)

References 69 publications

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“…In proton MRS (1H-MRS), protons chemically bound to different molecules can be differentiated by characteristic imprints of spectral resonances, the so-called chemical shifts [140] . The main resonances in brain 1H-MRS relate to N-acetylaspartate (NAA) as an indirect expression of the integrity and function of neurons, cholinecontaining compounds as a marker for cell membrane turnover indicating glial activity, creatine (Cr) including phosphocreatine as a marker for energy metabolism, as well as lactate as an indicator for anaerobic glycolysis detected under pathologic conditions [141,142] .…”

Section: Functional Imaging: Proton Magnetic Resonance Spectroscopymentioning

confidence: 99%

Significance of MRI in Diagnosis and Differential Diagnosis of Parkinson’s Disease

et al. 2010

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The differential diagnosis of parkinsonian syndromes is considered one of the most challenging in neurology, even for movement disorder specialists. Despite published consensus operational criteria for the diagnosis of Parkinson’s disease (PD) and the various atypical parkinsonian disorders (APDs) such as progressive supranuclear palsy, multiple system atrophy, and corticobasal syndrome, the clinical separation of APDs from PD carries a high rate of misdiagnosis. However, an early differentiation between APD and PD, each characterized by a largely different natural history, is crucial for determining the prognosis and choosing a treatment strategy. Despite limitations, the different modern magnetic resonance (MR) techniques have undoubtedly added to the differential diagnosis of neurodegenerative parkinsonism. Conventional MRI with visual assessment of T₂- and T₁-weighted imaging as well as various advanced MRI techniques offer objective measures and may therefore be useful tools in the diagnostic workup of PD and APDs. In clinical practice, conventional MRI is a well-established method for the exclusion of symptomatic parkinsonism due to other pathologies such as tumors, cerebral ischemia or inflammatory diseases. Furthermore, over the past two decades, advances in MR techniques have enabled to quantitatively illustrate abnormalities in the basal ganglia and infratentorial structures in APDs by methods such as magnetic resonance volumetry, diffusion-weighted imaging, magnetization transfer imaging and proton magnetic resonance spectroscopy. This article aims to review research findings on the value of MRI techniques in the differential diagnosis of neurodegenerative parkinsonian disorders.

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Section: Functional Imaging: Proton Magnetic Resonance Spectroscopymentioning

confidence: 99%

Significance of MRI in Diagnosis and Differential Diagnosis of Parkinson’s Disease

et al. 2010

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“…123 The main resonances in brain MRS relate to N-acetylaspartate (NAA) as an indirect expression of the integrity and function of neurons, choline (Cho) containing compounds as marker for cell membrane turn-over indicating glial activity, creatine (Cr) including phosphocreatine as a marker for energy metabolism, as well as lactate as an indicator for anaerobic glycolysis detected under pathologic conditions. 124,125 1H-MRS studies have shown reduced NAA/Cr and NAA/Cho ratios in the lentiform nucleus or striatum not only in APD but also in PD, 124,126 disproving previously published results, which suggested that 1H-MRS of striatal structures might differentiate APDs from PD by virtue of reduced NAA/Cr ratios in MSA but not PD.…”

Section: Proton Magnetic Resonance Spectroscopymentioning

confidence: 99%

Potential of advanced MR imaging techniques in the differential diagnosis of parkinsonism

et al. 2009

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The clinical differentiation of parkinsonian syndromes remains challenging not only for neurologists but also for movement disorder specialists. Conventional magnetic resonance imaging (cMRI) with the visual assessment of T2- and T1-weighted imaging as well as different advanced MRI techniques offer objective measures, which may be a useful tool in the diagnostic work-up of Parkinson's disease and atypical parkinsonian disorders (APDs). In clinical practice, cMRI is a well-established method for the exclusion of symptomatic parkinsonism due to other pathologies. Over the past two decades, abnormalities in the basal ganglia and infratentorial structures have been shown especially in APDs not only by cMRI but also by different advanced MRI techniques, including methods to assess regional cerebral atrophy quantitatively such as magnetic resonance volumetry, proton magnetic resonance spectroscopy, diffusion-weighted imaging, and magnetization transfer imaging. This article aims to review recent research findings on the role of advanced MRI techniques in the differential diagnosis of neurodegenerative parkinsonian disorders.

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“…In vivo 1 H-MRS visualizes signals from carbon-bound, non-exchangeable protons, showing the highest information density in the spectral region from 1 to 5 ppm [72]. Principal metabolites detected by 1 H-MRS include N-acetylaspartate as an indirect expression of the integrity of neurons, choline-containing compounds (such as metabolites involved in phospholipid membrane synthesis) as markers for glial activity, creatine (including phosphocreatine) as a marker for energy metabolism and lactate as an indicator for anaerobic glycolysis detected under pathologic conditions [73,74].…”

Section: Magnetic Resonance Spectroscopymentioning

confidence: 99%

An update on conventional and advanced magnetic resonance imaging techniques in the differential diagnosis of neurodegenerative parkinsonism

Seppi¹,

Schocke

2005

Current Opinion in Neurology

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Research findings suggest that novel MRI techniques such as MTI, DWI and MRV have superior sensitivity compared to conventional MRI in detecting abnormal features in neurodegenerative parkinsonian disorders. Whether these techniques will emerge as standard investigations in the work-up of patients presenting with parkinsonism requires further prospective magnetic resonance studies during early disease stages.

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In vivo 1H NMR spectroscopy of individual human brain metabolites at moderate field strengths

Cited by 30 publications

References 69 publications

Significance of MRI in Diagnosis and Differential Diagnosis of Parkinson’s Disease

Significance of MRI in Diagnosis and Differential Diagnosis of Parkinson’s Disease

Potential of advanced MR imaging techniques in the differential diagnosis of parkinsonism

An update on conventional and advanced magnetic resonance imaging techniques in the differential diagnosis of neurodegenerative parkinsonism

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