2018
DOI: 10.1590/1678-4324-20181600685
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Abstract: Acrylamide (AA), is an important industrial compound, formed during food processing under high temperature. Due to its potential carcinogenic effect, it has been recognized as a human health concern. In this study, we investigated the role of oxidative stress in acrylamide's genotoxicity and protective role of Lcarnitine (LCA) in human lymphocytes. The micronucleus test (MNT) was used to monitor AA genotoxicity after 20h exposure to concentrations of 0.25,50 and 100 mM. Furthermore we evaluated oxidative stres… Show more

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Cited by 12 publications
(59 citation statements)
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References 43 publications
(59 reference statements)
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“…In many in vivo and in vitro studies have been reported genotoxicity, cytotoxicity, oxidative stress and mitochondrial dysfunction induced by acrylamide [26,27]. Various genotoxicity experiments showed that acrylamide could develop the genotoxicity and carcinogenicity properties like induction of micronuclei and aberrations in blood cells such as, spleen lymphocytes and peripheral red blood cells, DNA damage in Comet assay in various organs and transgenic gene mutation in liver [28].…”
Section: Discussionmentioning
confidence: 99%
“…In many in vivo and in vitro studies have been reported genotoxicity, cytotoxicity, oxidative stress and mitochondrial dysfunction induced by acrylamide [26,27]. Various genotoxicity experiments showed that acrylamide could develop the genotoxicity and carcinogenicity properties like induction of micronuclei and aberrations in blood cells such as, spleen lymphocytes and peripheral red blood cells, DNA damage in Comet assay in various organs and transgenic gene mutation in liver [28].…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, since Fpg (less specific) was more effective in inducing DNA breaks during repair than OGG1 (which is more specific for repair of 8‐oxoguanine), this may imply that oxidative DNA damage is a relatively small component of the damage detected in the comet assay (Katen et al, 2017 ). Nevertheless, studies show the formation of 8‐oxoguanine via the production of ROS following treatment of biological systems with AA (Wang et al, 2015 , 2020 ; Katen et al, 2016a , b ; Şekeroğlu et al, 2017 ; Zamani et al, 2018 ; Salimi et al, 2021a , b ). Several studies also demonstrated an association between micronucleus formation and oxidative stress both in vitro and in vivo (Zhao et al, 2015a , b ; Şekeroğlu et al, 2017 ; Ankaiah et al, 2018 ; Zamani et al, 2018 ).…”
Section: Assessmentmentioning
confidence: 99%
“…Nevertheless, studies show the formation of 8‐oxoguanine via the production of ROS following treatment of biological systems with AA (Wang et al, 2015 , 2020 ; Katen et al, 2016a , b ; Şekeroğlu et al, 2017 ; Zamani et al, 2018 ; Salimi et al, 2021a , b ). Several studies also demonstrated an association between micronucleus formation and oxidative stress both in vitro and in vivo (Zhao et al, 2015a , b ; Şekeroğlu et al, 2017 ; Ankaiah et al, 2018 ; Zamani et al, 2018 ). Although oxidative DNA damage was reduced by various antioxidants, it should be noted, however, that it cannot be assumed that the various antioxidants studied necessarily inhibit DNA damage via the antioxidant activity.…”
Section: Assessmentmentioning
confidence: 99%
“…Many in vitro studies [22][23][24][25][26][27][28][29], and in vivo studies of animals [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] and humans [48][49][50][51][52][53][54][55][56][57][58][59] have reported different beneficial functions for carnitine. In the following, the main activities observed are reported.…”
Section: An Updated Shot Of Beneficial Properties: In Vitro and In Vivo Studiesmentioning
confidence: 99%
“…In vitro Antioxidant effects Inhibited acrylamide-induced genotoxicity in human lymphocytes through the improvement of oxidative stress. [24] In vitro Antioxidant effects Inhibited ROS production and reduced antioxidant activity. [25] In vitro Anti-aging effect Decreased epigenetic modification of hTERT gene promoter and the numbers of senescent cells, and increased activity of telomerase.…”
Section: Activity Effect Referencesmentioning
confidence: 99%