2001
DOI: 10.1590/s0037-86822001000400002
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In vitro study on thiabendazole action on viability of Ascaris lumbricoides (Lineu, 1758) eggs

Abstract: The in vitro activity of thiabendazole on Ascaris lumbricoides eggs, which were recovered from uteri of worm excreted after chemotherapeutic treatment, was studied. Four concentrations of the drug were used: 1 -2.5 -5 -and 10 ppm during 24, 48 and 72 hours of exposure. Subsequently, the eggs were centrifuged, washed three times and H 2 SO 4 0.1N was added. The eggs were maintained in an incubator for 20 days at 28 0 C. Finally, the percentage of embryonated eggs was determined under a lightmicroscope at a 100X… Show more

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Cited by 9 publications
(5 citation statements)
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References 6 publications
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“…Due to the preliminary nature of our research, the dosage of S-M-(-2MKA-BZ-5)TS was higher than that of benzimidazole drugs used by other researchers [27,28]. In addition to inhibiting the development of eggs, the drug we used in the highest doses (5, 10 mM) caused the destruction of roundworm eggs.…”
Section: Discussionmentioning
confidence: 81%
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“…Due to the preliminary nature of our research, the dosage of S-M-(-2MKA-BZ-5)TS was higher than that of benzimidazole drugs used by other researchers [27,28]. In addition to inhibiting the development of eggs, the drug we used in the highest doses (5, 10 mM) caused the destruction of roundworm eggs.…”
Section: Discussionmentioning
confidence: 81%
“…Additionally, the available anthelmintic drugs are mostly not ovicidal, but treatment with their use eliminates worms from infected hosts and thus is contributing to environmental contamination. In other words, such a treatment favors a temporary cure and then reinfection due to the excretion of parasite eggs into the ground through the feces [ 11 , 27 ].…”
Section: Discussionmentioning
confidence: 99%
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“…O processo de transmissão das helmintoses é amplificado especificamente pela resistência dos ovos a agentes terapêuticos (Souza et al, 1985;Massara 1988;Massara et al, 1991;Carvalho et al, 1992;Massara et al, 2001), a produtos de uso doméstico entre os quais detergentes e desinfetantes (Massara et al, 2003) e à radiação UV (Oliveira, 2003). Considerando-se a dispersão e resistência dos ovos, ambientes públicos de grande circulação de pessoas constituem espaços físicos que potencializam o processo de transmissão de parasitos intestinais.…”
Section: Introductionunclassified
“…Cada fêmea adulta do verme produz cerca de 200 mil ovos por dia, que são expelidos com as fezes na forma não embrionada, não infectante, podendo sobreviver no solo por mais de um ano, em condições adequadas. O embrionamento dos ovos ocorre após um período de, pelo menos, vinte dias (Massara et al, 2001) e a infecção do homem se dá pela ingestão destes ovos, quando levados à boca por mãos sujas ou alimentos contaminados.…”
Section: Introductionunclassified