In Vitro Study on Antibacterial Activity of Aqueous Extract and Silver Nanoparticles of Andrographis paniculata

Jayashree, S.; Vani, G. Sangeetha

doi:10.20546/ijcmas.2016.505.041

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…The antibacterial effect of AgNPs is related to the oxidation and release of Ag + ions, so it is an ideal bactericidal agent. The large surface-to-volume ratio and a large fraction of silver nanoparticles' surface atoms create a tremendous antimicrobial effect compared to silver metal [57]. Furthermore, because of their small size, AgNPs quickly penetrate cell membranes and affect intracellular processes.…”

Section: Antibacterial Activity Of Agnpsmentioning

confidence: 99%

Discovery of high antibacterial and antitumor effects against multi-drug resistant clinically isolated bacteria and MCF-7 and AGS cell lines by biosynthesized silver nanoparticles using Oxalis corniculata extract

2023

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The green technique is a unique way to produce functional nanoparticles. We examined the green synthesis of Ag nanoparticles (O-AgNPs) by the extract of Oxalis corniculata. Green-synthesized O-AgNPs were accomplished by monitoring critical factors such as concentration, pH, reaction time, and temperature. Several analytical techniques, including scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction analysis, and UV-Vis spectroscopy, were applied to characterize O-AgNPs. The SEM analysis showed O-AgNPs with a spherical shape and an average size of 33.57 nm. The XRD pattern indicated the face-centered cubic (fcc) structure of the prepared O-AgNPs. The anticancer activity of the synthesized O-AgNPs was investigated in MCF-7 (breast) and AGS (gastric) cell lines, indicating high anticancer effects against selected cell lines. The growth of all selected bacteria containing Gram+ and Gram- was inhibited by O-AgNPs. O-AgNPs showed greater inhibition in comparison to conventional antibiotics. As a result, our green synthesized AgNPs using plant extracts exhibited anticancer and antibacterial activities.

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Section: Antibacterial Activity Of Agnpsmentioning

confidence: 99%

Discovery of high antibacterial and antitumor effects against multi-drug resistant clinically isolated bacteria and MCF-7 and AGS cell lines by biosynthesized silver nanoparticles using Oxalis corniculata extract

2023

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“…Terpenoids have been reported that it had antibacterial, antiviral, antidiarrhoeal and antineoplastic effect [68]. The terpenoids exhibit antibacterial activity through the mechanism of membrane disruption by its lipophilic compounds [68,69]. The most common terpenoid compounds isolated from A. paniculata are diterpenoids lactones.…”

Section: Phytochemicals Constituents Of Leaf and Stem Extract Of A Pmentioning

confidence: 99%

Phytochemical and Antibacterial Properties of Andrographis paniculata (Burn.F.) on Enteric Bacteria Isolated from a Surface Water in Owena, Nigeria

Ayodele

Olalemi

Ogundare

2020

JAMB

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This study was aimed at determining the antibacterial activities of Andrographis paniculata on methicillin and vancomycin resistant enteric bacteria isolated from River Owena, Owena, Nigeria. Water samples were collected weekly from River Owena over a period of six weeks (n = 6). The bacteriological evaluation of the water samples was carried out using standard microbiological method. A. paniculata leaf and stem extracts were prepared using the polar (i.e., methanol) and nonpolar (i.e., n-hexane) solvents. The phytochemical constituents and antibacterial activity of all the extracts of A. paniculata leaf and stem were investigated using standard methods. Results revealed that methanol extracts from A. paniculata contained the maximum amount of phytochemicals when compared to that of the n- hexane extracts. Salmonella and Shigella were both resistant to vancomycin, while they were only susceptible to methicillin once throughout the sampling week. The methanol extracts from A. paniculata showed higher antibacterial activity against the targeted bacterial isolates of enteric origin which include E. coli, faecal coliforms, Shigella, Salmonella and intestinal enterococci. The methanol leaf extract of A. paniculata showed the maximum antibacterial activity against E. coli, Salmonella, Shigella, intestinal enterococci and faecal coliform with zones of inhibition 29.0 mm, 26.00 mm, 21.3 mm, 21 mm and 19 mm respectively. The methanollic stem extract of A. paniculata showed a maximum antibacterial activity against Salmonella with zone of inhibition of 25 mm while n-hexane stem extract exhibited a maximum zone inhibition of 17.6 mm against Salmonella. The minimum inhibitory concentration (MIC) value for all the A. paniculata extracts was at a concentration of 12.5 – 50 ml. The pH of the water ranged from 6.50 to 6.90, temperature ranged from 26 to 31°C. The findings from this study demonstrated that River Owena is highly contaminated with faecal materials and that leaf and stem extracts of A. paniculata may be used as antibacterial agents against methicillin and vancomycin resistant bacteria of enteric origin.

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Mechanism of action of bio-inspired nanosilver particles

Quratulain

Adil

QayyumAbdul

2018

Bioinspired, Biomimetic and Nanobiomaterials

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Nanotechnology is gaining prime importance in the present era due to modeling of metals in nanoparticles (NPs) by biological methods, but nowadays, researchers are designing the exact mode of action of nanomaterials on plants. NPs are fabricated by different physical and chemical methods, but biological methods are preferred due to their simplicity and non-toxic nature. The current development of biomimetic NP synthesis is a more reliable, economically favorable and eco-friendly method for the treatment of different diseases. NPs fabricated by traditional methods have shown a lot of demerits, so the green route to the formation of metallic NPs is advantageous compared to the use of microbes. Secondary metabolites in the plant have active chemical constituents which can act as capping and reducing agents, thereby enhancing the rate of reduction and stabilizations of NPs. In this review, a major focus is given to biogenic silver NPs’ mechanism of action toward cancer and microbes.

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In Vitro Study on Antibacterial Activity of Aqueous Extract and Silver Nanoparticles of Andrographis paniculata

Cited by 3 publications

References 7 publications

Discovery of high antibacterial and antitumor effects against multi-drug resistant clinically isolated bacteria and MCF-7 and AGS cell lines by biosynthesized silver nanoparticles using Oxalis corniculata extract

Discovery of high antibacterial and antitumor effects against multi-drug resistant clinically isolated bacteria and MCF-7 and AGS cell lines by biosynthesized silver nanoparticles using Oxalis corniculata extract

Phytochemical and Antibacterial Properties of Andrographis paniculata (Burn.F.) on Enteric Bacteria Isolated from a Surface Water in Owena, Nigeria

Mechanism of action of bio-inspired nanosilver particles

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