In vitro studies of mechanisms of cytotoxicity

Identification of the 1-cyano-3,4-epithiobutane-derived urinary mercapturic acidn-acetyl-s-(4-cyano-2-thio-1-butyl)-cysteine in male fischer 344 rats

“…Aminooxyacetic acid inhibits the conversion of cysteine conjugates to reactive thiols in addition to pyruvate and ammonia. 18 The cysteine conjugate of CEB, therefore, may be excreted into the urine or serve as a substrate for N-acetyltransferase and increase the formation and urinary excretion of the corresponding mercapturic acid.…”

Identification of the 1-cyano-3,4-epithiobutane-derived urinary mercapturic acidn-acetyl-s-(4-cyano-2-thio-1-butyl)-cysteine in male fischer 344 rats

“…Aminooxyacetic acid inhibits the conversion of cysteine conjugates to reactive thiols in addition to pyruvate and ammonia. 18 The cysteine conjugate of CEB, therefore, may be excreted into the urine or serve as a substrate for N-acetyltransferase and increase the formation and urinary excretion of the corresponding mercapturic acid.…”

Identification of the 1-cyano-3,4-epithiobutane-derived urinary mercapturic acidn-acetyl-s-(4-cyano-2-thio-1-butyl)-cysteine in male fischer 344 rats

“…Aminooxyacetic acid inhibits the conversion of cysteine conjugates to reactive thiols in addition to pyruvate and ammonia. 18 The cysteine conjugate of CEB, therefore, may be excreted into the urine or serve as a substrate for N-acetyltransferase and increase the formation and urinary excretion of the corresponding mercapturic acid.…”

Identification of the 1-cyano-3,4-epithiobutane-derived urinary mercapturic acidn-acetyl-s-(4-cyano-2-thio-1-butyl)-cysteine in male fischer 344 rats

“…Aminooxyacetic acid inhibits the conversion of cysteine conjugates to reactive thiols in addition to pyruvate and ammonia. 18 The cysteine conjugate of CEB, therefore, may be excreted into the urine or serve as a substrate for N-acetyltransferase and increase the formation and urinary excretion of the corresponding mercapturic acid.…”