In vitro release studies of chlorpheniramine maleate from gels prepared by different cellulose derivatives

Taş, Çetin; Özkan, Yalçın; Savaşer, Ayhan; Baykara, Tamer

doi:10.1016/s0014-827x(03)00080-6

Cited by 77 publications

(32 citation statements)

References 23 publications

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“…may not give the chance of observing enhancing effect of chemical enhancer (Tas et al 2003). However, permeability coefficient and steady-state flux value of the formulation containing menthol were found higher than the other formulations (Table 2).…”

Section: In Vitro Release Studiesmentioning

confidence: 85%

In VitroandEx VivoPermeation Studies of Etodolac from Hydrophilic Gels and Effect of Terpenes as Enhancers

et al. 2007

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Section: In Vitro Release Studiesmentioning

confidence: 85%

In VitroandEx VivoPermeation Studies of Etodolac from Hydrophilic Gels and Effect of Terpenes as Enhancers

et al. 2007

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“…At the end of the study, SSD released from nanosuspension and ammoniacal solution was 73.65% and 90.53%, respectively. It is reported that the release of an active substance from formulation and its penetration through the diffusion barriers is inversely related to viscosity of the formulation (32). Therefore, SSD release from nanosuspension was significantly high compared to SSD nanogel (P<0.05).…”

Section: In Vitro Release Studiesmentioning

confidence: 97%

Silver Sulfadiazine Nanosystems for Burn Therapy

Venkataraman

Nagarsenker

2012

AAPS PharmSciTech

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Abstract. The objective of the present study was to formulate stable silver sulfadiazine (SSD) nanosuspensions and nanogels suitable for topical delivery with a view to increase bactericidal activity in burn therapy. SSD nanosuspensions were formulated using the microprecipitation-high-pressure homogenization technique. An optimized microsuspension of 0.5% SSD formulated with 6% Cremophor EL and 4% Lauroglycol 90 was subjected to 30 cycles of 1,000-bar pressure to give a nanosuspension with an average particle size of 367.85 nm. Transmission electron microscopy studies revealed that ovoid-to rectangularshaped SSD particles were present as clusters. It was evident through X-ray diffraction studies that SSD was present in amorphous state both in microprecipitate and in nanosuspension. SSD (0.5%) nanogels were prepared using 1% Carbopol 974 P for topical delivery of nanosized SSD. In vitro release studies demonstrated that SSD release was faster from solutions and nanosuspensions compared to gel formulation owing to the influence of the gel matrix on SSD release. The bacterial inhibitory efficiency of SSD nanosuspension was as good as that of SSD solution against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. In vivo studies revealed that a nanogel containing 0.5% SSD was more effective in wound healing compared to 0.5% and 1% marketed cream.

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“…The mixture was shaken for 1h at 200 cycles/min (B. Braun Melsungen AG, Melsungen, Germany) and then 100μL of this solution was transferred into a 10mL volumetric flask and adjusted with pH7.4 isotonic phosphate buffer (15,16). The resulting solutions were then filtered by 0.45μm membrane filters and then assayed as described above.…”

Section: Drug Content Studiesmentioning

confidence: 99%

Permeation Studies of Indomethacin from Different Emulsions for Nasal Delivery and Their Possible Anti-Inflammatory Effects

et al. 2008

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Abstract. The purpose of this research was to develop an emulsion formulation of indomethacin (IND) suitable for nasal delivery. IND was incorporated into the oil phases of oil in water (O/W) and water in oil (W/O) emulsions. For this purpose, different emulsifying agents (Tween 80, Span 80 and Brij 58) were used in two emulsion formulations. When the effects of several synthetic membranes (nylon, cellulose, cellulose nitrate) were compared with the sheep nasal mucosa, the cellulose membrane and sheep nasal mucosa showed similar permeation properties for O/W emulsion (P > 0.05). To examine the absorption characteristics of IND, the anti-inflammatory properties of intravenous solution of IND, intranasal O/W emulsions of IND (with or without enhancers) and intranasal solution of IND (IND-Sol) were investigated in rats with carrageenan-induced paw edema. When citric acid was added to the nasal emulsion, the anti-inflammatory activity was similar to that of intravenous solution (P > 0.05). Finally, it was concluded that, intranasal administration of IND emulsion with citric acid may be considered as an alternative to intravenous and per oral administrations of IND to overcome their adverse effects.

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In vitro release studies of chlorpheniramine maleate from gels prepared by different cellulose derivatives

Cited by 77 publications

References 23 publications

In VitroandEx VivoPermeation Studies of Etodolac from Hydrophilic Gels and Effect of Terpenes as Enhancers

In VitroandEx VivoPermeation Studies of Etodolac from Hydrophilic Gels and Effect of Terpenes as Enhancers

Silver Sulfadiazine Nanosystems for Burn Therapy

Permeation Studies of Indomethacin from Different Emulsions for Nasal Delivery and Their Possible Anti-Inflammatory Effects

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