In vitro release of α-tocopherol from emulsion-loaded β-lactoglobulin gels

Liang, Li; Line, Valérie Leung Sok; Remondetto, Gabriel; Subirade, Muriel

doi:10.1016/j.idairyj.2009.09.008

Cited by 86 publications

(42 citation statements)

References 26 publications

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“…The reliability study of Vitamin E in CGPVE was conducted using a solution of pepsin and sodium chloride and also in the solution of pancreatin and buffer phosphate following the procedure from previous researchers [16,17]. 150 mg of CGPVE was added by 30 mL of SGF solution and 5 mL of tween 80 and stirred at 100 rpm for 30 min at 37°C.…”

Section: In Vitro Study Of Cgpve Filmmentioning

confidence: 99%

Incorporation of Vitamin E Onto Cross-Linked Galactomannan Phosphate Matrix and in Vitro Study

Tarigan

Purba

Zuhra

2018

Asian J Pharm Clin Res

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Objective: This study demonstrated the incorporation of Vitamin E from palm fatty acid distillate onto crosslinked galactomannan phosphate (CGP) matrix.Methods: CGP was obtained from the crosslinking reaction of galactomannan from Arenga pinnata (GAP) with tri-sodium metaphosphate (TMF) ranging from 1:1 to 4:3 while incorporation of Vitamin E was conducted in two steps to form films. The reliability study of Vitamin E in CGPVE was conducted using a solution of pepsin and sodium chloride and also in solution of pancreatin and buffer phosphate. Results:The Fourier-transform infrared spectrum indicated the presence of phosphate in CGP while the scanning electron microscope images depicted the changes of surface morphology from smooth (GAP) to rough and hollow (CGP) which confirmed that crosslink had occurred. The swelling study of CGP showed that the swelling indexes were similar and decreased with the increase of TMF. The efficiency of CGP to absorb Vitamin E ranged from 89.66% to 91.09%. The in vitro releasing study of Vitamin E in simulated gastric fluid and simulated intestinal fluid showed that only a small amount of Vitamin E was released.Conclusions: This study demonstrated that CGP can be prepared and is potentially useful for drug delivery to the colon.

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Section: In Vitro Study Of Cgpve Filmmentioning

confidence: 99%

Incorporation of Vitamin E Onto Cross-Linked Galactomannan Phosphate Matrix and in Vitro Study

Tarigan

Purba

Zuhra

2018

Asian J Pharm Clin Res

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“…However, the utilization of a-tocopherol as a functional ingredient in food and beverages is currently limited owing to its heat and oxygen sensitivity, poor water-solubility, and low and variable bioavailability [9][10][11][12]. A number of different a-tocopherol delivery systems have been investigated as potential means to overcome these problems, including oil-in-water (O/W) nanoemulsions and emulsions [13][14][15][16][17][18], nanodispersions [19], nanostructured lipid particles [20], liposomes [21], and biopolymer-based nanoparticles [22][23][24]. Emulsion-based delivery systems have been found to be particularly suitable for improving the oral administration of oil-soluble vitamins [25].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of vitamin E-enriched nanoemulsions: Factors affecting particle size using spontaneous emulsification

Saberi

Yuan

McClements

2013

Journal of Colloid and Interface Science

384

237

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“…The pepsin-susceptible groups are then exposed to attack by the enzyme. Liang et al (2010) reported a similar result, in which b-Lg gels were degraded much more quickly in the presence of enzyme-containing SGF than they were in SIF.…”

Section: Effect Of Digestion Media On Protein Digestionmentioning

confidence: 62%

“…Indeed, reports (Beaulieu et al, 2002) suggest that hydrophobic amino acid residues left exposed during the denaturation step interact with the lipid phase in the final microgels, thereby masking them against enzymatic digestion. It has also been suggested that the products of partial protein hydrolysis can again adsorb to the oil droplet surface and have an additional protective effect on impeding digestion of the matrices (Liang et al, 2010). So the incorporation of lipid into the matrix can provide a means by which to impede the enzymatic degradation of the WP microgels.…”

Section: Effect Of Lipid Load On Protein Digestionmentioning

confidence: 99%

Cold-set whey protein microgels containing immobilised lipid phases to modulate matrix digestion and release of a water-soluble bioactive

Egan

Jacquier

Rosenberg

et al. 2013

Journal of Microencapsulation

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This study investigated the in-vitro digestibility of cold-set whey protein (WP) microgels prepared by two gelation methods (external and internal) containing lipids (0%, 10% or 20% w/w). The incorporation of lipids into these matrices achieved higher entrapment of the bioactive vitamin riboflavin, as well as significant reductions in rates of both the digestion of the protein matrix, and the subsequent diffusion of the water-soluble bioactive. A biexponential model accounted for the contribution of digestion-and diffusion-driven mechanisms in describing the release of riboflavin into enzyme containing simulated gastrointestinal fluids. In particular, for external gelation microgels, as the lipid load within the matrices increased, the contribution of a faster diffusion-driven release was almost completely negated by a slower digestion-assisted release. Lipid loads provided a composite matrix capable of alternating from a burst to a sustained release of bioactive.

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In vitro release of α-tocopherol from emulsion-loaded β-lactoglobulin gels

Cited by 86 publications

References 26 publications

Incorporation of Vitamin E Onto Cross-Linked Galactomannan Phosphate Matrix and in Vitro Study

Incorporation of Vitamin E Onto Cross-Linked Galactomannan Phosphate Matrix and in Vitro Study

Fabrication of vitamin E-enriched nanoemulsions: Factors affecting particle size using spontaneous emulsification

Cold-set whey protein microgels containing immobilised lipid phases to modulate matrix digestion and release of a water-soluble bioactive

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